pyrantel and Helminthiasis--Animal

Topics: Animals; Anthelmintics; Dose-Response Relationship, Drug; Drug Resistance; Feces; Fenbendazole; Helminthiasis, Animal; Horse Diseases; Horses; Parasite Egg Count; Parasitic Sensitivity Tests; Pyrantel; Treatment Outcome; United Kingdom

The efficacy, safety and palatability of a new flavoured chewable anthelmintic tablet were investigated in dogs. The efficacy, based on worm counts, of a single recommended therapeutic dose (RTD) of 5 mg pyrantel + 20 mg oxantel + 5 mg praziquantel/kg bodyweight was assessed in experimental infections (EI) and natural infections (NI) with Trichuris vulpis, Echinococcus granulosus and Toxocara canis. For T vulpis, the efficacy of the treatment was 99.3 per cent in EI (comparing groups of six treated and six control dogs) and 100 per cent in NI (nine treated and nine control dogs). For E granulosus, the efficacy was more than 99.9 per cent in EI (11 treated and 11 control dogs). For T canis, the efficacy was 94.3 per cent in EI (10 treated and 10 control dogs) and 100 per cent in NI (12 treated and 13 control dogs). In a field study, Ancylostoma caninum (11 dogs) and T canis (11 dogs) faecal egg counts were reduced by more than 99 per cent, and in eight dogs with Dipylidium caninum proglotides in the faeces the efficacy was 100 per cent. The tablets were readily consumed by 56 of 64 (87.5 per cent) privately owned dogs. Safety was assessed in groups of six dogs treated either once with twice the RTD, once with six times the RTD, with twice the RTD on three consecutive days, or untreated. There were no significant differences in blood parameters between the groups, and no abnormal clinical findings. Two dogs treated with six times the RTD vomited, but no vomiting was observed when administration was repeated two days later.

Topics: Animals; Anthelmintics; Dog Diseases; Dogs; Drug Resistance; Drug Therapy, Combination; Feces; Female; Helminthiasis, Animal; Male; Parasite Egg Count; Praziquantel; Pyrantel; Taste; Treatment Outcome

Three anthelmintic pastes were compared in terms of their ability to suppress the output of parasite eggs in the faeces of 108 grazing horses at four sites in Britain; the horses were treated once with either ivermectin, fenbendazole or pyrantel. At each site, the horses grazed together throughout the trials which took place during the summers of 1985 and 1986. The median periods before parasite eggs reappeared in faeces were 70 days for ivermectin, 14 days for fenbendazole and 39 days for pyrantel embonate. Geometric mean faecal egg counts in the groups treated with ivermectin and pyrantel were significantly less (P less than 0.05) than in the fenbendazole group on days 21, 28, 35 and 42 after treatment. On days 49, 56, 63 and 70 the mean egg counts in the ivermectin group were significantly lower (P less than 0.05) than those in either of the other groups. The results indicated that in order to ensure minimal contamination of pastures, grazing horses treated with ivermectin paste would have required a second treatment approximately 10 weeks after the first, and to achieve similar control with fenbendazole or pyrantel embonate, a second treatment would have been required after approximately two weeks and six weeks, respectively.

Topics: Animals; Benzimidazoles; Feces; Female; Fenbendazole; Helminthiasis; Helminthiasis, Animal; Horse Diseases; Horses; Ivermectin; Male; Parasite Egg Count; Pyrantel; Pyrantel Pamoate; Random Allocation; Recurrence; Statistics as Topic; Time Factors

Topics: Animals; Anthelmintics; Dichlorvos; Fenbendazole; Helminthiasis; Helminthiasis, Animal; Hygromycin B; Ivermectin; Lactones; Levamisole; Piperazine; Piperazines; Pyrantel; Swine; Swine Diseases; Thiabendazole

Topics: Amidines; Animals; Anthelmintics; Benzimidazoles; Cats; Cattle; Diethylcarbamazine; Dogs; Helminthiasis; Helminthiasis, Animal; Horses; Ivermectin; Lactones; Levamisole; Morantel; Organophosphorus Compounds; Piperazine; Piperazines; Praziquantel; Pyrantel; Salicylanilides; Sheep; Tetramisole

Topics: Animals; Dog Diseases; Dogs; Helminthiasis; Helminthiasis, Animal; Pyrantel; Pyrantel Pamoate; Wisconsin