pyrantel and Giardiasis

Topics: Amebiasis; Amides; Ancylostomiasis; Ascariasis; Bephenium Compounds; Cestode Infections; Emetine; Furazolidone; Giardiasis; Humans; Hydroxyquinolines; Intestinal Diseases, Parasitic; Mebendazole; Metronidazole; Necatoriasis; Niclosamide; Oxyuriasis; Paromomycin; Piperazines; Pyrantel; Pyrimidines; Pyrvinium Compounds; Quinacrine; Strongyloidiasis; Tetramisole; Thiabendazole; Thiocyanates; Trichuriasis

This study evaluated the effect of two combination products containing febantel, pyrantel, and praziquantel (FPP) for the treatment of Giardia species in experimentally infected kittens. In experiment 1, five kittens were administered the United States (US) formulation of FPP at doses of 37.8 mg/kg, 7.56 mg/kg, and 7.56 mg/kg, respectively, PO, q24h, for 5 days and four kittens remained as controls. In experiment 2, five kittens were administered the European formulation of FPP at the doses of 12.5 mg/kg, 12 mg/kg, and 4.16 mg/kg, respectively, PO, q24h, for 5 days and four kittens remained as controls. In experiment 3, six kittens were administered the US formulation of FPP at 56.5 mg/kg, 11.3 mg/kg, 11.3 mg/kg, respectively, PO, q24h, for 5 days and five kittens remained as controls. Thirteen days after treatment, kittens testing negative for Giardia species cysts were administered 20 mg/kg methylprednisolone acetate, IM, weekly for a maximum of two injections. Feces were analyzed for Giardia species cysts using a direct immunofluorescence test. After experiment 3, four of the six treated kittens, but no control kittens, remained negative for Giardia species after the administration of methylprednisolone acetate.

Topics: Aging; Animals; Anthelmintics; Cat Diseases; Cats; Drug Combinations; Female; Giardiasis; Guanidines; Male; Praziquantel; Pyrantel; Tablets; Treatment Outcome

To determine efficacy of treatment with a combination febantel-praziquantel-pyrantel product, with or without vaccination with a commercial Giardia vaccine, in dogs with naturally occurring giardiasis.. Prospective trial.. 16 Beagles naturally infected with Giardia duodenalis.. During phase 1, 6 dogs were treated with the parasiticide for 3 days (4 were also vaccinated). Four weeks later, all 6 dogs were treated with the parasiticide again for 5 days and were bathed and moved to clean cages after the last treatment (phase 2). Nine dogs were treated with the parasiticide for 3 (n = 4) or 5 (5) days and bathed and moved to clean cages after the last treatment (phase 3). Fecal samples were collected twice weekly for 24 days after treatment and tested for cysts with a quantitative zinc sulfate flotation technique and for Giardia antigen with an immunoassay.. Dogs in phase 1 were all shedding cysts again by day 24. In phase 2, only 1 dog shed cysts after treatment, and shedding was transient (day 17). In phase 3, neither cysts nor antigen was detected in fecal samples from 2 of 4 dogs treated for 3 days and 4 of 5 dogs treated for 5 days. In 18 of 57 (31.6%) fecal samples, cysts were seen, but results of the immunoassay were negative.. Results suggest that when a combination febantel-praziquantel-pyrantel product is used to treat dogs with giardiasis, bathing and changing the environment after treatment may be more important in preventing recurrence than duration of treatment.

Topics: Animals; Anthelmintics; Antigens, Protozoan; Dog Diseases; Dogs; Drug Combinations; Feces; Female; Giardia; Giardiasis; Guanidines; Hygiene; Male; Praziquantel; Prospective Studies; Protozoan Vaccines; Pyrantel; Secondary Prevention; Tablets; Treatment Outcome; Vaccination