pycnidione and Malaria--Falciparum

pycnidione has been researched along with Malaria--Falciparum* in 1 studies

Other Studies

1 other study(ies) available for pycnidione and Malaria--Falciparum

Article	Year
Potential antimalarial lead structures from fungi of marine origin. Planta medica, 2005, Volume: 71, Issue:10 Antiplasmodial and cytotoxicity testing of five highly oxygenated natural products (6R,12R,14R-colletoketol, 6R,11R,12R,14R-colletoketodiol, dihydrobotrydial, pycnidione, and 3R,4S-hydroxymellein), all derived from fungi of marine origin, showed one of them, pycnidione, to have activities against three different strains of Plasmodium falciparum in the sub-micromolar (microM) range. Although the mean selectivity index of 1 for the observed antiplasmodial activity of 4 is low, pycnidione's usefulness as a potential lead structure should not be ignored. Topics: Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Fungi; Heterocyclic Compounds, 4 or More Rings; Humans; KB Cells; Malaria, Falciparum; Parasitic Sensitivity Tests; Phytotherapy; Plasmodium falciparum; Seawater; Structure-Activity Relationship; Tropolone	2005

Article

Year

Potential antimalarial lead structures from fungi of marine origin.

Planta medica, 2005, Volume: 71, Issue:10

Antiplasmodial and cytotoxicity testing of five highly oxygenated natural products (6R,12R,14R-colletoketol, 6R,11R,12R,14R-colletoketodiol, dihydrobotrydial, pycnidione, and 3R,4S-hydroxymellein), all derived from fungi of marine origin, showed one of them, pycnidione, to have activities against three different strains of Plasmodium falciparum in the sub-micromolar (microM) range. Although the mean selectivity index of 1 for the observed antiplasmodial activity of 4 is low, pycnidione's usefulness as a potential lead structure should not be ignored.

Topics: Animals; Antimalarials; Antineoplastic Agents, Phytogenic; Fungi; Heterocyclic Compounds, 4 or More Rings; Humans; KB Cells; Malaria, Falciparum; Parasitic Sensitivity Tests; Phytotherapy; Plasmodium falciparum; Seawater; Structure-Activity Relationship; Tropolone

2005