pyclen has been researched along with Neurodegenerative-Diseases* in 1 studies
1 other study(ies) available for pyclen and Neurodegenerative-Diseases
| Article | Year |
|---|---|
A potent antioxidant small molecule aimed at targeting metal-based oxidative stress in neurodegenerative disorders.
Metal-ion misregulation and oxidative stress have been linked to the progressive neurological decline associated with multiple neurodegenerative disorders. Transition metal-mediated oxidation of biomolecules via Fenton chemical reactions plays a role in disease progression. Herein we report the synthesis, characterization and antioxidant activity of 2; a pyclen derivative with enhanced antioxidant character. Topics: Antioxidants; Azabicyclo Compounds; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Models, Molecular; Molecular Structure; Molecular Weight; Neurodegenerative Diseases; Organometallic Compounds; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Structure-Activity Relationship; Transition Elements | 2013 |