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putrescine and Seizures

putrescine has been researched along with Seizures in 16 studies

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"The role of excitatory amino acid receptors in the genesis of motor and electrocortical seizures, elicited by administration of the polyamine putrescine into the deep prepiriform cortex, has been evaluated in rats."7.68Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex. ( Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C, 1993)
" Repeated administration of a subthreshold dose of cocaine resulted in the development of sensitization to cocaine-induced seizures during an initial 3 or 4 days, followed by the development of tolerance to seizures on days 5 and 6."3.69Increased polyamine levels and changes in the sensitivity to convulsions during chronic treatment with cocaine in mice. ( Marley, RJ; Saito, T; Shimosato, K; Watanabe, S, 1995)
"We have previously shown that daily treatment with subconvulsant dose of cocaine resulted in the elevation of brain levels of polyamines such as putrescine and spermidine and the development of increased susceptibility to cocaine-induced seizures."3.69Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine. ( Katsura, M; Ohkuma, S; Shimosato, K; Watanabe, S, 1997)
"The role of excitatory amino acid receptors in the genesis of motor and electrocortical seizures, elicited by administration of the polyamine putrescine into the deep prepiriform cortex, has been evaluated in rats."3.68Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex. ( Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C, 1993)
" Moreover, its use is less toxic and safer."1.42Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine. ( Gmiro, VE; Serdyuk, SE; Veselkina, OS, 2015)
"KA-induced seizure activity did not significantly alter both variables until PND 21."1.28Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain. ( Baudry, M; el-Skaf, G; Lynch, G; Najm, I; Tocco, G; Vanderklish, P, 1992)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.25)18.7374
1990's11 (68.75)18.2507
2000's2 (12.50)29.6817
2010's1 (6.25)24.3611
2020's1 (6.25)2.80

Authors

AuthorsStudies
Kovács, Z1
Skatchkov, SN1
Szabó, Z1
Qahtan, S1
Méndez-González, MP1
Malpica-Nieves, CJ1
Eaton, MJ1
Kardos, J1
Héja, L1
Gmiro, VE1
Serdyuk, SE1
Veselkina, OS1
Kaasinen, SK1
Gröhn, OH1
Keinänen, TA1
Alhonen, L2
Jänne, J2
Porta, R1
Doyle, RL1
Tatter, SB1
Wilens, TE1
Schatz, RA1
Sellinger, OZ1
Shimosato, K2
Watanabe, S2
Marley, RJ1
Saito, T1
Chu, PJ1
Shirahata, A1
Samejima, K1
Saito, H1
Abe, K1
Baudry, M2
Najm, I2
Halonen, T1
Sivenius, J1
Miettinen, R1
Halmekytö, M1
Kauppinen, R1
Sinervirta, R1
Alakuijala, L1
MacDonald, E1
De Sarro, GB1
Bagetta, G1
Spagnolo, C1
Nisticò, G1
Hayashi, Y2
Hattori, Y2
Moriwaki, A1
Lu, YF1
Hori, Y2
Uskova, NI1
Lysenko, AV1
Mendzheritskii, AM1
Katsura, M1
Ohkuma, S1
Lee, YK1
Lee, SR1
Kim, CY1
el-Skaf, G1
Tocco, G1
Vanderklish, P1
Lynch, G1
Nakao, J1
Hasegawa, T1
Hashimoto, H1
Noto, T1
Nakajima, T1

Other Studies

16 other studies available for putrescine and Seizures

ArticleYear
Putrescine Intensifies Glu/GABA Exchange Mechanism and Promotes Early Termination of Seizures.
    International journal of molecular sciences, 2022, Jul-25, Volume: 23, Issue:15

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; gamma-Aminobutyric Acid; P

2022
Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine.
    Bulletin of experimental biology and medicine, 2015, Volume: 160, Issue:1

    Topics: Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Antiparkinson Agents; Bridged-Ring Comp

2015
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
    Experimental neurology, 2003, Volume: 183, Issue:2

    Topics: Acetyltransferases; Animals; Biogenic Polyamines; Brain; Cell Count; Crosses, Genetic; Dose-Response

2003
The biosynthesis of polyamines in the brain of audiogenic seizure-susceptible and -resistant deermice.
    Journal of neurochemistry, 1981, Volume: 37, Issue:3

    Topics: Acoustic Stimulation; Animals; Brain; Chromatography, High Pressure Liquid; Methionine; Peromyscus;

1981
Increased polyamine levels and changes in the sensitivity to convulsions during chronic treatment with cocaine in mice.
    Brain research, 1995, Jul-03, Volume: 684, Issue:2

    Topics: Animals; Brain Chemistry; Cocaine; Hippocampus; Male; Mice; Mice, Inbred Strains; Polyamines; Putres

1995
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo.
    European journal of pharmacology, 1994, Apr-21, Volume: 256, Issue:2

    Topics: Animals; Cyclohexylamines; Drug Interactions; Injections, Intraventricular; Male; Mice; Mice, Inbred

1994
Kainate-induced seizure activity stimulates the polyamine interconversion pathway in rat brain.
    Neuroscience letters, 1994, Apr-25, Volume: 171, Issue:1-2

    Topics: Acetylation; Acetyltransferases; Animals; Biogenic Polyamines; Brain; Brain Chemistry; Kainic Acid;

1994
Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain.
    The European journal of neuroscience, 1993, Sep-01, Volume: 5, Issue:9

    Topics: Animals; Brain; Differential Threshold; Electroshock; Escape Reaction; Immunohistochemistry; Learnin

1993
Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex.
    Neuropharmacology, 1993, Volume: 32, Issue:1

    Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Dizocilpine Mal

1993
Increases in brain polyamine concentrations in chemical kindling and single convulsion induced by pentylenetetrazol in rats.
    Neuroscience letters, 1993, Jan-04, Volume: 149, Issue:1

    Topics: Animals; Brain; Kindling, Neurologic; Male; Osmolar Concentration; Pentylenetetrazole; Putrescine; R

1993
[Comparative investigation of anticonvulsive effects of putrescine and structural analogues of delta-sleep-inducing peptide].
    Vestnik Rossiiskoi akademii meditsinskikh nauk, 1996, Issue:9

    Topics: Animals; Brain; Carnosine; Delta Sleep-Inducing Peptide; gamma-Aminobutyric Acid; Hyperbaric Oxygena

1996
Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine.
    Brain research, 1997, Nov-14, Volume: 775, Issue:1-2

    Topics: Animals; Brain Chemistry; Cocaine; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Dr

1997
Melatonin attenuates the changes in polyamine levels induced by systemic kainate administration in rat brains.
    Journal of the neurological sciences, 2000, Sep-15, Volume: 178, Issue:2

    Topics: Animals; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Hippocampus; Kainic Acid; Mal

2000
Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain.
    Brain research. Developmental brain research, 1992, Sep-18, Volume: 69, Issue:1

    Topics: Animals; Benzodiazepinones; Biogenic Polyamines; Brain; Brain Chemistry; Cerebral Cortex; Electropho

1992
Involvement of putrescine in the development of kindled seizure in rats.
    Journal of neurochemistry, 1992, Volume: 58, Issue:2

    Topics: Amygdala; Animals; Brain; Eflornithine; Electroencephalography; Frontal Lobe; Kindling, Neurologic;

1992
Formation of GABOB from 2-hydroxyputrescine and its anticonvulsant effect.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 40, Issue:2

    Topics: 4-Aminobutyrate Transaminase; Amine Oxidase (Copper-Containing); Amino Acids; Animals; Anticonvulsan

1991