putrescine has been researched along with Seizures in 16 studies
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of excitatory amino acid receptors in the genesis of motor and electrocortical seizures, elicited by administration of the polyamine putrescine into the deep prepiriform cortex, has been evaluated in rats." | 7.68 | Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex. ( Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C, 1993) |
| " Repeated administration of a subthreshold dose of cocaine resulted in the development of sensitization to cocaine-induced seizures during an initial 3 or 4 days, followed by the development of tolerance to seizures on days 5 and 6." | 3.69 | Increased polyamine levels and changes in the sensitivity to convulsions during chronic treatment with cocaine in mice. ( Marley, RJ; Saito, T; Shimosato, K; Watanabe, S, 1995) |
| "We have previously shown that daily treatment with subconvulsant dose of cocaine resulted in the elevation of brain levels of polyamines such as putrescine and spermidine and the development of increased susceptibility to cocaine-induced seizures." | 3.69 | Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine. ( Katsura, M; Ohkuma, S; Shimosato, K; Watanabe, S, 1997) |
| "The role of excitatory amino acid receptors in the genesis of motor and electrocortical seizures, elicited by administration of the polyamine putrescine into the deep prepiriform cortex, has been evaluated in rats." | 3.68 | Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex. ( Bagetta, G; De Sarro, GB; Nisticò, G; Spagnolo, C, 1993) |
| " Moreover, its use is less toxic and safer." | 1.42 | Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine. ( Gmiro, VE; Serdyuk, SE; Veselkina, OS, 2015) |
| "KA-induced seizure activity did not significantly alter both variables until PND 21." | 1.28 | Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain. ( Baudry, M; el-Skaf, G; Lynch, G; Najm, I; Tocco, G; Vanderklish, P, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 11 (68.75) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Kovács, Z | 1 |
| Skatchkov, SN | 1 |
| Szabó, Z | 1 |
| Qahtan, S | 1 |
| Méndez-González, MP | 1 |
| Malpica-Nieves, CJ | 1 |
| Eaton, MJ | 1 |
| Kardos, J | 1 |
| Héja, L | 1 |
| Gmiro, VE | 1 |
| Serdyuk, SE | 1 |
| Veselkina, OS | 1 |
| Kaasinen, SK | 1 |
| Gröhn, OH | 1 |
| Keinänen, TA | 1 |
| Alhonen, L | 2 |
| Jänne, J | 2 |
| Porta, R | 1 |
| Doyle, RL | 1 |
| Tatter, SB | 1 |
| Wilens, TE | 1 |
| Schatz, RA | 1 |
| Sellinger, OZ | 1 |
| Shimosato, K | 2 |
| Watanabe, S | 2 |
| Marley, RJ | 1 |
| Saito, T | 1 |
| Chu, PJ | 1 |
| Shirahata, A | 1 |
| Samejima, K | 1 |
| Saito, H | 1 |
| Abe, K | 1 |
| Baudry, M | 2 |
| Najm, I | 2 |
| Halonen, T | 1 |
| Sivenius, J | 1 |
| Miettinen, R | 1 |
| Halmekytö, M | 1 |
| Kauppinen, R | 1 |
| Sinervirta, R | 1 |
| Alakuijala, L | 1 |
| MacDonald, E | 1 |
| De Sarro, GB | 1 |
| Bagetta, G | 1 |
| Spagnolo, C | 1 |
| Nisticò, G | 1 |
| Hayashi, Y | 2 |
| Hattori, Y | 2 |
| Moriwaki, A | 1 |
| Lu, YF | 1 |
| Hori, Y | 2 |
| Uskova, NI | 1 |
| Lysenko, AV | 1 |
| Mendzheritskii, AM | 1 |
| Katsura, M | 1 |
| Ohkuma, S | 1 |
| Lee, YK | 1 |
| Lee, SR | 1 |
| Kim, CY | 1 |
| el-Skaf, G | 1 |
| Tocco, G | 1 |
| Vanderklish, P | 1 |
| Lynch, G | 1 |
| Nakao, J | 1 |
| Hasegawa, T | 1 |
| Hashimoto, H | 1 |
| Noto, T | 1 |
| Nakajima, T | 1 |
16 other studies available for putrescine and Seizures
| Article | Year |
|---|---|
Putrescine Intensifies Glu/GABA Exchange Mechanism and Promotes Early Termination of Seizures.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; gamma-Aminobutyric Acid; P | 2022 |
Comparison of Pharmacological Potency and Safety of Glutamate Blocker IEM-1913 and Memantine.
Topics: Analgesics; Animals; Anticonvulsants; Antidepressive Agents; Antiparkinson Agents; Bridged-Ring Comp | 2015 |
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice.
Topics: Acetyltransferases; Animals; Biogenic Polyamines; Brain; Cell Count; Crosses, Genetic; Dose-Response | 2003 |
The biosynthesis of polyamines in the brain of audiogenic seizure-susceptible and -resistant deermice.
Topics: Acoustic Stimulation; Animals; Brain; Chromatography, High Pressure Liquid; Methionine; Peromyscus; | 1981 |
Increased polyamine levels and changes in the sensitivity to convulsions during chronic treatment with cocaine in mice.
Topics: Animals; Brain Chemistry; Cocaine; Hippocampus; Male; Mice; Mice, Inbred Strains; Polyamines; Putres | 1995 |
N-(3-aminopropyl)-cyclohexylamine blocks facilitation by spermidine of N-methyl-DL-aspartate-induced seizure in mice in vivo.
Topics: Animals; Cyclohexylamines; Drug Interactions; Injections, Intraventricular; Male; Mice; Mice, Inbred | 1994 |
Kainate-induced seizure activity stimulates the polyamine interconversion pathway in rat brain.
Topics: Acetylation; Acetyltransferases; Animals; Biogenic Polyamines; Brain; Brain Chemistry; Kainic Acid; | 1994 |
Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain.
Topics: Animals; Brain; Differential Threshold; Electroshock; Escape Reaction; Immunohistochemistry; Learnin | 1993 |
Antagonists of N-methyl-D-aspartate receptors block seizures induced by putrescine in the deep prepiriform cortex.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; Dizocilpine Mal | 1993 |
Increases in brain polyamine concentrations in chemical kindling and single convulsion induced by pentylenetetrazol in rats.
Topics: Animals; Brain; Kindling, Neurologic; Male; Osmolar Concentration; Pentylenetetrazole; Putrescine; R | 1993 |
[Comparative investigation of anticonvulsive effects of putrescine and structural analogues of delta-sleep-inducing peptide].
Topics: Animals; Brain; Carnosine; Delta Sleep-Inducing Peptide; gamma-Aminobutyric Acid; Hyperbaric Oxygena | 1996 |
Role of cerebral spermidine in the development of sensitization to convulsant activity of cocaine and lidocaine.
Topics: Animals; Brain Chemistry; Cocaine; Convulsants; Dose-Response Relationship, Drug; Drug Synergism; Dr | 1997 |
Melatonin attenuates the changes in polyamine levels induced by systemic kainate administration in rat brains.
Topics: Animals; Brain; Cerebral Cortex; Chromatography, High Pressure Liquid; Hippocampus; Kainic Acid; Mal | 2000 |
Seizure activity-induced changes in polyamine metabolism and neuronal pathology during the postnatal period in rat brain.
Topics: Animals; Benzodiazepinones; Biogenic Polyamines; Brain; Brain Chemistry; Cerebral Cortex; Electropho | 1992 |
Involvement of putrescine in the development of kindled seizure in rats.
Topics: Amygdala; Animals; Brain; Eflornithine; Electroencephalography; Frontal Lobe; Kindling, Neurologic; | 1992 |
Formation of GABOB from 2-hydroxyputrescine and its anticonvulsant effect.
Topics: 4-Aminobutyrate Transaminase; Amine Oxidase (Copper-Containing); Amino Acids; Animals; Anticonvulsan | 1991 |