putrescine has been researched along with Pancreatic Neoplasms in 9 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " On the basis of these prior findings, we investigated the effects of alpha-difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase, alone and in combination with cis-diamminedichloroplatinum(II) (cisplatin), to which two of the four cell lines display relative resistance." | 1.27 | Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II). ( Black, O; Chang, BK; Gutman, R, 1984) |
| "CsA had inhibitory effects on H2T pancreatic cancer growth similar to those of alpha-DFMO; these effects were blocked by the addition of the polyamine putrescine." | 1.27 | Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro. ( Barranco, SC; James, E; Saydjari, R; Thompson, JC; Townsend, CM, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, BK | 2 |
| Black, O | 1 |
| Gutman, R | 1 |
| Sjöholm, A | 3 |
| Arkhammar, P | 1 |
| Welsh, N | 2 |
| Bokvist, K | 1 |
| Rorsman, P | 1 |
| Hallberg, A | 1 |
| Nilsson, T | 1 |
| Welsh, M | 1 |
| Berggren, PO | 1 |
| Honkanen, RE | 1 |
| Hoftiezer, V | 1 |
| Bankston, PW | 1 |
| Hellerström, C | 1 |
| Nicolet, T | 1 |
| Scemama, JL | 2 |
| Pradayrol, L | 2 |
| Berthélémy, P | 1 |
| Seva, C | 2 |
| Vaysse, N | 2 |
| Löser, C | 1 |
| Fölsch, UR | 1 |
| Paprotny, C | 1 |
| Creutzfeldt, W | 1 |
| Nicolet, TG | 1 |
| Saydjari, R | 1 |
| Townsend, CM | 1 |
| Barranco, SC | 1 |
| James, E | 1 |
| Thompson, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 other studies available for putrescine and Pancreatic Neoplasms
| Article | Year |
|---|---|
Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II).
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Cisplatin; Cricetinae; Drug | 1984 |
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne | 1993 |
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Sec | 2000 |
Inhibitory effects of a calcium antagonist on ornithine decarboxylase induction in pancreatic cancer cell lines.
Topics: Animals; Calcium; Eflornithine; Enzyme Induction; Ornithine Decarboxylase; Ornithine Decarboxylase I | 1991 |
Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F).
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line; Cytoplasmic Granules; Eflornithin | 1991 |
Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.
Topics: Animals; Biological Transport; Cell Division; Cell Line; Cells, Cultured; Dexamethasone; Eflornithin | 1991 |
Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer.
Topics: Antigens, Tumor-Associated, Carbohydrate; Biogenic Polyamines; Cadaverine; Carcinoembryonic Antigen; | 1990 |
Characterization of putrescine- and spermidine-transport systems of a rat pancreatic acinar tumoral cell line (AR4-2J).
Topics: Amino Acids; Animals; Biological Transport; Intracellular Fluid; Kinetics; Pancreatic Neoplasms; Put | 1990 |
Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro.
Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Line; Cell Survival; Cricetinae; | 1986 |