putrescine has been researched along with Melanoma in 20 studies
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 7.75 | Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. ( Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N, 2009) |
| " We demonstrate that multidrug resistant human melanoma cells (M14 ADR) are more sensitive than the corresponding wild type cells (M14 WT) to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 7.73 | Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD, 2006) |
| "As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent." | 7.69 | Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. ( Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E, 1995) |
| "The regulation of putrescine transport in difluoromethylornithine-treated B16 melanoma cells by extracellular Ca2+ has been investigated." | 7.69 | Extracellular calcium stimulates Na(+)-dependent putrescine uptake in B16 melanoma cells. ( Martin, RL; Minchin, RF, 1997) |
| " Median effect analysis of the DFMO + IFN inhibition of C8161 cells demonstrated that the 2 agents interacted synergistically over the entire dose-response curve." | 5.27 | Difluoromethylornithine enhances inhibition of melanoma cell growth in soft agar by dexamethasone, clone A interferon and retinoic acid. ( Bregman, MD; Meyskens, FL, 1986) |
| "It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 3.75 | Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. ( Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N, 2009) |
| " We demonstrate that multidrug resistant human melanoma cells (M14 ADR) are more sensitive than the corresponding wild type cells (M14 WT) to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine." | 3.73 | Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD, 2006) |
| "As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent." | 3.69 | Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. ( Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E, 1995) |
| "The regulation of putrescine transport in difluoromethylornithine-treated B16 melanoma cells by extracellular Ca2+ has been investigated." | 3.69 | Extracellular calcium stimulates Na(+)-dependent putrescine uptake in B16 melanoma cells. ( Martin, RL; Minchin, RF, 1997) |
| "The polyamines putrescine, cadaverine, spermidine, spermine, and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection." | 3.66 | [Polyamine levels in blood and plasma of patients with malignant melanoma]. ( Desser, H; Gebhart, W; Kläring, WJ; Luger, T, 1982) |
| "The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice." | 3.66 | Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980) |
| " Median effect analysis of the DFMO + IFN inhibition of C8161 cells demonstrated that the 2 agents interacted synergistically over the entire dose-response curve." | 1.27 | Difluoromethylornithine enhances inhibition of melanoma cell growth in soft agar by dexamethasone, clone A interferon and retinoic acid. ( Bregman, MD; Meyskens, FL, 1986) |
| " A dose-response curve was developed for each interferon in which the maximum dose applied gave at least 30% growth inhibition of control values after 96-128 h of continuous exposure." | 1.27 | The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines. ( Harvey, HA; Leitzel, KE; Lipton, A; Pegg, AE; Wolf, LM, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (65.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 3 (15.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Agostinelli, E | 2 |
| Condello, M | 2 |
| Molinari, A | 2 |
| Tempera, G | 1 |
| Viceconte, N | 1 |
| Arancia, G | 2 |
| Belli, F | 1 |
| Palmigiani, P | 1 |
| Vedova, LD | 1 |
| Marra, M | 1 |
| Seiler, N | 1 |
| Desser, H | 1 |
| Kläring, WJ | 1 |
| Luger, T | 1 |
| Gebhart, W | 1 |
| Prussak, CE | 1 |
| Russell, DH | 2 |
| Takami, H | 1 |
| Nishioka, K | 2 |
| Pisha, E | 1 |
| Chai, H | 1 |
| Lee, IS | 1 |
| Chagwedera, TE | 1 |
| Farnsworth, NR | 1 |
| Cordell, GA | 1 |
| Beecher, CW | 1 |
| Fong, HH | 1 |
| Kinghorn, AD | 1 |
| Brown, DM | 1 |
| Naredi, P | 1 |
| Hafström, L | 1 |
| Zachrisson, H | 1 |
| Rudenstam, CM | 1 |
| Lundholm, K | 1 |
| Shappell, NW | 1 |
| Fogel-Petrovic, MF | 1 |
| Porter, CW | 1 |
| Minchin, RF | 1 |
| Martin, RL | 1 |
| Hattori, T | 1 |
| Itoh, S | 1 |
| Hayashi, H | 1 |
| Chiba, T | 1 |
| Takii, T | 1 |
| Yoshizaki, K | 1 |
| Onozaki, K | 2 |
| Pavel, P | 1 |
| Schwippelová, Z | 1 |
| Fair, WR | 2 |
| Miller, TR | 1 |
| Siegel, BA | 1 |
| Welch, MJ | 2 |
| Coleman, RE | 1 |
| Straatmann, MG | 1 |
| Asberry, BE | 1 |
| Primeau, JL | 1 |
| Ter-Pogossian, MM | 1 |
| Townsend, RM | 1 |
| Banda, PW | 1 |
| Marton, LJ | 1 |
| Fleisher, JH | 1 |
| Endo, Y | 2 |
| Matsushima, K | 2 |
| Oppenheim, JJ | 2 |
| Bregman, MD | 1 |
| Meyskens, FL | 1 |
| Wolf, LM | 1 |
| Leitzel, KE | 1 |
| Pegg, AE | 1 |
| Harvey, HA | 1 |
| Lipton, A | 1 |
| Romsdahl, MM | 1 |
1 review available for putrescine and Melanoma
| Article | Year |
|---|---|
[Polyamines and malignant melanoma (author's transl)].
Topics: Animals; Humans; Mammals; Melanoma; Polyamines; Putrescine; Skin Neoplasms; Spermidine; Spermine | 1979 |
19 other studies available for putrescine and Melanoma
| Article | Year |
|---|---|
Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line | 2009 |
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.
Topics: Animals; Annexin A5; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Dose-Response Relations | 2006 |
[Polyamine levels in blood and plasma of patients with malignant melanoma].
Topics: Adult; Aged; Cadaverine; Clinical Laboratory Techniques; Female; Humans; Male; Melanoma; Middle Aged | 1982 |
Single-step high-performance liquid chromatographic method for the analysis of acetylated polyamines.
Topics: Chromatography, High Pressure Liquid; Humans; Leukemia; Male; Melanoma; Mesothelioma; Putrescine; Re | 1982 |
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm | 1980 |
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; DNA Damage; Growth Inhibitors | 1995 |
Whole body energy expenditure protein breakdown and polyamine excretion during high dose treatment with interleukin-2 and interferon-alpha.
Topics: Aged; Carcinoma, Renal Cell; Cytokines; Energy Metabolism; Female; Humans; Interferon alpha-2; Inter | 1994 |
Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis.
Topics: Acetyltransferases; Blotting, Northern; Eflornithine; Gene Expression Regulation, Enzymologic; Homeo | 1993 |
Extracellular calcium stimulates Na(+)-dependent putrescine uptake in B16 melanoma cells.
Topics: Animals; Biological Transport; Calcium; Carrier Proteins; Cell Membrane; Melanoma; Mice; Polyamines; | 1997 |
CHOP, a basic leucine zipper transcriptional factor, contributes to the antiproliferative effect of IL-1 on A375 human melanoma cells through augmenting transcription of IL-6.
Topics: Adjuvants, Immunologic; Antineoplastic Agents; CCAAT-Enhancer-Binding Proteins; Growth Inhibitors; H | 2001 |
Radionuclide imaging of dog prostate.
Topics: Animals; Carbon Radioisotopes; Dogs; Ileum; Male; Melanoma; Mice; Prostate; Putrescine; Radionuclide | 1978 |
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne | 1977 |
Polyamines in malignant melanoma. Urinary excretion and disease progress.
Topics: Female; Humans; Male; Melanoma; Polyamines; Putrescine; Spermidine; Spermine | 1976 |
Estimation of urinary diamines and polyamines by thin-layer chromatography.
Topics: Breast Neoplasms; Cadaverine; Chromatography, Thin Layer; Dansyl Compounds; Diamines; Humans; Melano | 1975 |
Role of ornithine decarboxylase in the regulation of cell growth by IL-1 and tumor necrosis factor.
Topics: Animals; Cell Division; Cell Line; DNA; Eflornithine; Glioma; Growth Inhibitors; Humans; Interleukin | 1988 |
Difluoromethylornithine enhances inhibition of melanoma cell growth in soft agar by dexamethasone, clone A interferon and retinoic acid.
Topics: Cell Line; Cell Survival; Dexamethasone; Drug Combinations; Drug Synergism; Eflornithine; Humans; In | 1986 |
Mechanism of in vitro antitumor effects of interleukin 1 (IL 1).
Topics: Cell Cycle; Cell Differentiation; Cell Line; Cell Survival; Cytotoxicity, Immunologic; Humans; Immun | 1986 |
The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Drug Interactions; | 1985 |
Elevation of putrescine and spermidine in sera of patients with solid tumors.
Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc | 1974 |