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putrescine and Melanoma

putrescine has been researched along with Melanoma in 20 studies

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
"It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."7.75Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. ( Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N, 2009)
" We demonstrate that multidrug resistant human melanoma cells (M14 ADR) are more sensitive than the corresponding wild type cells (M14 WT) to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."7.73Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD, 2006)
"As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent."7.69Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. ( Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E, 1995)
"The regulation of putrescine transport in difluoromethylornithine-treated B16 melanoma cells by extracellular Ca2+ has been investigated."7.69Extracellular calcium stimulates Na(+)-dependent putrescine uptake in B16 melanoma cells. ( Martin, RL; Minchin, RF, 1997)
" Median effect analysis of the DFMO + IFN inhibition of C8161 cells demonstrated that the 2 agents interacted synergistically over the entire dose-response curve."5.27Difluoromethylornithine enhances inhibition of melanoma cell growth in soft agar by dexamethasone, clone A interferon and retinoic acid. ( Bregman, MD; Meyskens, FL, 1986)
"It has been confirmed that multidrug resistant (MDR) human melanoma cells are more sensitive than their wild-type counterparts to H2O2 and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."3.75Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound. ( Agostinelli, E; Arancia, G; Condello, M; Molinari, A; Tempera, G; Viceconte, N, 2009)
" We demonstrate that multidrug resistant human melanoma cells (M14 ADR) are more sensitive than the corresponding wild type cells (M14 WT) to hydrogen peroxide and aldehydes, the products of bovine serum amine oxidase (BSAO)-catalyzed oxidation of spermine."3.73Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527. ( Agostinelli, E; Arancia, G; Belli, F; Condello, M; Marra, M; Molinari, A; Palmigiani, P; Seiler, N; Vedova, LD, 2006)
"As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent."3.69Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. ( Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E, 1995)
"The regulation of putrescine transport in difluoromethylornithine-treated B16 melanoma cells by extracellular Ca2+ has been investigated."3.69Extracellular calcium stimulates Na(+)-dependent putrescine uptake in B16 melanoma cells. ( Martin, RL; Minchin, RF, 1997)
"The polyamines putrescine, cadaverine, spermidine, spermine, and the amine histamine in whole blood and plasma of 42 patients with malignant melanoma were analysed after cold acid extraction and ion-exchange chromatography by fluorescence detection."3.66[Polyamine levels in blood and plasma of patients with malignant melanoma]. ( Desser, H; Gebhart, W; Kläring, WJ; Luger, T, 1982)
"The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice."3.66Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980)
" Median effect analysis of the DFMO + IFN inhibition of C8161 cells demonstrated that the 2 agents interacted synergistically over the entire dose-response curve."1.27Difluoromethylornithine enhances inhibition of melanoma cell growth in soft agar by dexamethasone, clone A interferon and retinoic acid. ( Bregman, MD; Meyskens, FL, 1986)
" A dose-response curve was developed for each interferon in which the maximum dose applied gave at least 30% growth inhibition of control values after 96-128 h of continuous exposure."1.27The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines. ( Harvey, HA; Leitzel, KE; Lipton, A; Pegg, AE; Wolf, LM, 1985)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-199013 (65.00)18.7374
1990's4 (20.00)18.2507
2000's3 (15.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Agostinelli, E2
Condello, M2
Molinari, A2
Tempera, G1
Viceconte, N1
Arancia, G2
Belli, F1
Palmigiani, P1
Vedova, LD1
Marra, M1
Seiler, N1
Desser, H1
Kläring, WJ1
Luger, T1
Gebhart, W1
Prussak, CE1
Russell, DH2
Takami, H1
Nishioka, K2
Pisha, E1
Chai, H1
Lee, IS1
Chagwedera, TE1
Farnsworth, NR1
Cordell, GA1
Beecher, CW1
Fong, HH1
Kinghorn, AD1
Brown, DM1
Naredi, P1
Hafström, L1
Zachrisson, H1
Rudenstam, CM1
Lundholm, K1
Shappell, NW1
Fogel-Petrovic, MF1
Porter, CW1
Minchin, RF1
Martin, RL1
Hattori, T1
Itoh, S1
Hayashi, H1
Chiba, T1
Takii, T1
Yoshizaki, K1
Onozaki, K2
Pavel, P1
Schwippelová, Z1
Fair, WR2
Miller, TR1
Siegel, BA1
Welch, MJ2
Coleman, RE1
Straatmann, MG1
Asberry, BE1
Primeau, JL1
Ter-Pogossian, MM1
Townsend, RM1
Banda, PW1
Marton, LJ1
Fleisher, JH1
Endo, Y2
Matsushima, K2
Oppenheim, JJ2
Bregman, MD1
Meyskens, FL1
Wolf, LM1
Leitzel, KE1
Pegg, AE1
Harvey, HA1
Lipton, A1
Romsdahl, MM1

Reviews

1 review available for putrescine and Melanoma

ArticleYear
[Polyamines and malignant melanoma (author's transl)].
    Ceskoslovenska dermatologie, 1979, Volume: 54, Issue:2

    Topics: Animals; Humans; Mammals; Melanoma; Polyamines; Putrescine; Skin Neoplasms; Spermidine; Spermine

1979

Other Studies

19 other studies available for putrescine and Melanoma

ArticleYear
Cytotoxicity of spermine oxidation products to multidrug resistant melanoma M14 ADR2 cells: sensitization by the MDL 72527 lysosomotropic compound.
    International journal of oncology, 2009, Volume: 35, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line

2009
Toxicity of enzymatic oxidation products of spermine to human melanoma cells (M14): sensitization by heat and MDL 72527.
    Biochimica et biophysica acta, 2006, Volume: 1763, Issue:10

    Topics: Animals; Annexin A5; Cell Line, Tumor; Cell Survival; CHO Cells; Cricetinae; Dose-Response Relations

2006
[Polyamine levels in blood and plasma of patients with malignant melanoma].
    Onkologie, 1982, Volume: 5, Issue:1

    Topics: Adult; Aged; Cadaverine; Clinical Laboratory Techniques; Female; Humans; Male; Melanoma; Middle Aged

1982
Single-step high-performance liquid chromatographic method for the analysis of acetylated polyamines.
    Journal of chromatography, 1982, Apr-16, Volume: 229, Issue:1

    Topics: Chromatography, High Pressure Liquid; Humans; Leukemia; Male; Melanoma; Mesothelioma; Putrescine; Re

1982
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
    British journal of cancer, 1980, Volume: 41, Issue:5

    Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm

1980
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis.
    Nature medicine, 1995, Volume: 1, Issue:10

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; DNA Damage; Growth Inhibitors

1995
Whole body energy expenditure protein breakdown and polyamine excretion during high dose treatment with interleukin-2 and interferon-alpha.
    The European journal of surgery = Acta chirurgica, 1994, Volume: 160, Issue:2

    Topics: Aged; Carcinoma, Renal Cell; Cytokines; Energy Metabolism; Female; Humans; Interferon alpha-2; Inter

1994
Regulation of spermidine/spermine N1-acetyltransferase by intracellular polyamine pools. Evidence for a functional role in polyamine homeostasis.
    FEBS letters, 1993, Apr-26, Volume: 321, Issue:2-3

    Topics: Acetyltransferases; Blotting, Northern; Eflornithine; Gene Expression Regulation, Enzymologic; Homeo

1993
Extracellular calcium stimulates Na(+)-dependent putrescine uptake in B16 melanoma cells.
    The international journal of biochemistry & cell biology, 1997, Volume: 29, Issue:3

    Topics: Animals; Biological Transport; Calcium; Carrier Proteins; Cell Membrane; Melanoma; Mice; Polyamines;

1997
CHOP, a basic leucine zipper transcriptional factor, contributes to the antiproliferative effect of IL-1 on A375 human melanoma cells through augmenting transcription of IL-6.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2001, Volume: 21, Issue:5

    Topics: Adjuvants, Immunologic; Antineoplastic Agents; CCAAT-Enhancer-Binding Proteins; Growth Inhibitors; H

2001
Radionuclide imaging of dog prostate.
    Urology, 1978, Volume: 12, Issue:5

    Topics: Animals; Carbon Radioisotopes; Dogs; Ileum; Male; Melanoma; Mice; Prostate; Putrescine; Radionuclide

1978
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1977, Volume: 18, Issue:1

    Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne

1977
Polyamines in malignant melanoma. Urinary excretion and disease progress.
    Cancer, 1976, Volume: 38, Issue:5

    Topics: Female; Humans; Male; Melanoma; Polyamines; Putrescine; Spermidine; Spermine

1976
Estimation of urinary diamines and polyamines by thin-layer chromatography.
    Journal of chromatography, 1975, Jul-16, Volume: 110, Issue:2

    Topics: Breast Neoplasms; Cadaverine; Chromatography, Thin Layer; Dansyl Compounds; Diamines; Humans; Melano

1975
Role of ornithine decarboxylase in the regulation of cell growth by IL-1 and tumor necrosis factor.
    Journal of immunology (Baltimore, Md. : 1950), 1988, Oct-01, Volume: 141, Issue:7

    Topics: Animals; Cell Division; Cell Line; DNA; Eflornithine; Glioma; Growth Inhibitors; Humans; Interleukin

1988
Difluoromethylornithine enhances inhibition of melanoma cell growth in soft agar by dexamethasone, clone A interferon and retinoic acid.
    International journal of cancer, 1986, Jan-15, Volume: 37, Issue:1

    Topics: Cell Line; Cell Survival; Dexamethasone; Drug Combinations; Drug Synergism; Eflornithine; Humans; In

1986
Mechanism of in vitro antitumor effects of interleukin 1 (IL 1).
    Immunobiology, 1986, Volume: 172, Issue:3-5

    Topics: Cell Cycle; Cell Differentiation; Cell Line; Cell Survival; Cytotoxicity, Immunologic; Humans; Immun

1986
The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines.
    Journal of biological response modifiers, 1985, Volume: 4, Issue:4

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Drug Interactions;

1985
Elevation of putrescine and spermidine in sera of patients with solid tumors.
    Clinica chimica acta; international journal of clinical chemistry, 1974, Dec-02, Volume: 57, Issue:2

    Topics: Autoanalysis; Breast Neoplasms; Cadaverine; Carbon Radioisotopes; Carcinoma; Chromatography, Ion Exc

1974