putrescine has been researched along with Experimental Neoplasms in 45 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Isogabaculine (3-amino-1,3-cyclohexadienyl carboxylic acid; RMI 71,932), an irreversible inhibitor of GABA transaminase, when added to mouse neuroblastoma cells in spinner culture at the time of induction of cell proliferation, increased ornithine decarboxylase (ODC) activity threefold above that of normal control cells and twofold above that of GABA (gamma-aminobutyric acid)-treated cells." | 3.66 | Effect of GABA and isogabaculine on ornithine decarboxylase and putrescine metabolism. ( Diekema, KA; Lippert, BJ; McCann, PP, 1982) |
| "The levels of polyamines (putrescine, spermidine and spermine) in erythrocytes and plasma were studied using Cloudman S-91 melanoma grown in the lungs of DBA/2 mice." | 3.66 | Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. ( Nishioka, K; Takami, H, 1980) |
| "Cancers are a broad spectrum of diseases in which there are altered growth fractions and cell-turnover fractions, and therefore cancer chemotherapeutic agents have been developed to take tumor kinetics into account." | 2.36 | Clinical relevance of polyamines as biochemical markers of tumor kinetics. ( Russell, DH, 1977) |
| " The present study demonstrated that long-term administration of DFMO has an inhibitory effect on tumors and metastasis, and induces differentiation of tumor cells from anaplastic round cells to well-differentiated pleomorphic cells in NiSS tumorigenesis in soft tissue." | 1.29 | Effects on tumor induction, growth, metastasis and histology of concurrent administration of putrescine and its metabolizing inhibitor alpha-difluoromethylornithine in nickel tumorigenesis in soft tissue. ( Ohmori, T; Okada, K; Shibata, T; Tabei, R, 1994) |
| "Putrescine was found to augment strongly the in vivo priming for secondary in vitro cytotoxic responses by small numbers of syngeneic ESb-D tumor cells and MHC-compatible allogeneic cells (minor H-antigens)." | 1.27 | Putrescine and its biosynthetic precursor L-ornithine augment the in vivo immunization against minor histocompatibility antigens and syngeneic tumor cells. ( Dröge, W; Häcker-Shahin, B, 1986) |
| "RBC putrescine levels were significantly increased at a tumor weight of 12." | 1.27 | Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats. ( Grossie, VB; Martin, RG; Nishioka, K; Ota, DM, 1986) |
| "(c) Spermine levels were significantly lowered, with 3 minima corresponding to the putrescine maxima." | 1.26 | Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide. ( Aussel, C; Lafaurie, M; Lalanne, CM; Milano, G; Soula, G; Stora, C, 1981) |
| "Kinetic analyses showed that liver and hepatoma enzymes had a similar Km and Vmax for putrescine incorporation into cell protein." | 1.26 | Differential transglutaminase distribution in normal rat liver and rat hepatoma. ( Birckbichler, PJ; Orr, GR; Patterson, MK, 1976) |
| "Quiescent, contact inhibited H-35 rat hepatoma cell cultures maintained in minimal essential medium contain a very low level of ornithine decarboxylase activity." | 1.26 | The appearance of an ornithine decarboxylase inhibitory protein upon the addition of putrescine to cell cultures. ( Canellakis, ES; Fong, WF; Heller, JS, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 40 (88.89) | 18.7374 |
| 1990's | 2 (4.44) | 18.2507 |
| 2000's | 2 (4.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (2.22) | 2.80 |
| Authors | Studies |
|---|---|
| Bey, P | 1 |
| Danzin, C | 1 |
| Van Dorsselaer, V | 1 |
| Mamont, P | 1 |
| Jung, M | 1 |
| Tardif, C | 1 |
| Xu, B | 1 |
| Tong, T | 1 |
| Wang, X | 1 |
| Liu, F | 1 |
| Zhang, X | 1 |
| Hu, X | 1 |
| Li, X | 1 |
| Yang, X | 1 |
| Liao, F | 1 |
| Hamaoki, M | 1 |
| Nagata, A | 1 |
| Chen, KY | 1 |
| Rinehart, CA | 1 |
| Russell, DH | 4 |
| Chaney, JE | 1 |
| Kobayashi, K | 1 |
| Goto, R | 1 |
| Digenis, GA | 1 |
| Schindler, J | 1 |
| Kelly, M | 1 |
| McCann, PP | 2 |
| Oredsson, SM | 1 |
| Deen, DF | 1 |
| Marton, LJ | 7 |
| Seppänen, P | 1 |
| Takigawa, M | 1 |
| Verma, AK | 1 |
| Simsiman, RC | 1 |
| Boutwell, RK | 1 |
| Diekema, KA | 1 |
| Lippert, BJ | 1 |
| Milano, G | 1 |
| Aussel, C | 1 |
| Stora, C | 1 |
| Lafaurie, M | 1 |
| Soula, G | 1 |
| Lalanne, CM | 1 |
| Anehus, S | 1 |
| Bengtsson, G | 1 |
| Andersson, G | 1 |
| Carlsson, G | 1 |
| Hafström, L | 1 |
| Yngner, T | 1 |
| Heby, O | 3 |
| Seidenfeld, J | 3 |
| Takami, H | 1 |
| Nishioka, K | 2 |
| Ohmori, T | 1 |
| Okada, K | 1 |
| Tabei, R | 1 |
| Shibata, T | 1 |
| Coleman, CS | 1 |
| Pegg, AE | 2 |
| Megosh, LC | 1 |
| Guo, Y | 1 |
| Sawicki, JA | 1 |
| O'Brien, TG | 1 |
| Birckbichler, PJ | 1 |
| Orr, GR | 1 |
| Patterson, MK | 1 |
| Scalabrino, G | 1 |
| Pösö, H | 1 |
| Hölttä, E | 1 |
| Hannonen, P | 1 |
| Kallio, A | 1 |
| Jänne, J | 1 |
| Kallistratos, G | 3 |
| Fasske, E | 1 |
| Looney, WB | 2 |
| Kovacs, CJ | 2 |
| Hopkins, HA | 2 |
| Dattilo, JW | 1 |
| Morris, HP | 2 |
| Fong, WF | 1 |
| Heller, JS | 1 |
| Canellakis, ES | 1 |
| Perin, A | 1 |
| Sessa, A | 1 |
| Fujita, K | 2 |
| Nagatsu, T | 2 |
| Shinpo, K | 1 |
| Maruta, K | 2 |
| Takahashi, H | 1 |
| Sekiya, A | 1 |
| Welch, MJ | 1 |
| Coleman, RE | 1 |
| Straatmann, MG | 1 |
| Asberry, BE | 1 |
| Primeau, JL | 1 |
| Fair, WR | 1 |
| Ter-Pogossian, MM | 1 |
| Seiler, N | 2 |
| Lamberty, U | 1 |
| Al-Therib, MJ | 1 |
| Lee, PL | 2 |
| Kallistratos, U | 1 |
| Ito, M | 1 |
| Senba, H | 1 |
| Halline, AG | 1 |
| Dudeja, PK | 1 |
| Jacoby, RF | 1 |
| Llor, X | 1 |
| Teng, BB | 1 |
| Chowdhury, LN | 1 |
| Davidson, NO | 1 |
| Brasitus, TA | 1 |
| Uchida, K | 1 |
| Rademaker, A | 1 |
| Oyasu, R | 1 |
| Hull, WE | 1 |
| Kunz, W | 1 |
| Port, RE | 1 |
| Häcker-Shahin, B | 1 |
| Dröge, W | 1 |
| Grossie, VB | 1 |
| Ota, DM | 1 |
| Martin, RG | 1 |
| Hibasami, H | 1 |
| Tsukada, T | 1 |
| Nakashima, K | 1 |
| Berdinskikh, NK | 1 |
| Lialiushko, NM | 1 |
| Williams-Ashman, HG | 1 |
| Coppoc, GL | 1 |
| Weber, G | 1 |
| LeGendre, SM | 1 |
| Yancey, ST | 1 |
| Laki, K | 1 |
| Wilson, CB | 1 |
3 reviews available for putrescine and Experimental Neoplasms
| Article | Year |
|---|---|
Clinical relevance of polyamines.
Topics: Animals; Cadaverine; Cystic Fibrosis; Diamines; Female; Growth Disorders; Humans; Kidney Failure, Ch | 1983 |
Clinical relevance of polyamines as biochemical markers of tumor kinetics.
Topics: Animals; Humans; Kinetics; Neoplasms; Neoplasms, Experimental; Polyamines; Putrescine; Rats; Spermid | 1977 |
[Cancer metastasis and polyamines].
Topics: Adenosylmethionine Decarboxylase; Animals; Humans; Lung Neoplasms; Mammary Neoplasms, Experimental; | 1985 |
42 other studies available for putrescine and Experimental Neoplasms
| Article | Year |
|---|---|
Analogues of ornithine as inhibitors of ornithine decarboxylase. New deductions concerning the topography of the enzyme's active site.
Topics: Animals; Binding Sites; Carboxy-Lyases; Cattle; In Vitro Techniques; Liver; Male; Neoplasms, Experim | 1978 |
Short divalent ethacrynic amides as pro-inhibitors of glutathione
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Dru | 2022 |
Host macrophages produce diacetylspermine related with tumorigenesis.
Topics: Animals; Cell Line, Tumor; Coculture Techniques; Dose-Response Relationship, Drug; Female; Glucose; | 2006 |
Difference in putrescine transport in undifferentiated versus differentiated mouse NB-15 neuroblastoma cells.
Topics: Animals; Biological Transport, Active; Cell Differentiation; Cell Line; Cyclic AMP; Kinetics; Mice; | 1981 |
Tumor selective enhancement of radioactivity uptake in mice treated with alpha-difluoromethylornithine prior to administration of 14C-putrescine.
Topics: Animals; Brain; Carbon Radioisotopes; Eflornithine; Lung; Male; Mice; Mice, Inbred BALB C; Neoplasms | 1983 |
Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation.
Topics: Animals; Carboxy-Lyases; Cell Differentiation; Cell Line; Eflornithine; Mice; Neoplasms, Experimenta | 1983 |
Decreased cytotoxicity of cis-diamminedichloroplatinum(II) by alpha-difluoromethylornithine depletion of polyamines in 9L rat brain tumor cells in vitro.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cisplatin; DNA; Eflornithine; Neoplasms, Experimental; Orn | 1982 |
Some properties of the polyamine deprivation-inducible uptake system for methylglyoxal bis(guanylhydrazone) in tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Iodoacetates; Iodoacet | 1981 |
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; | 1982 |
Effect of GABA and isogabaculine on ornithine decarboxylase and putrescine metabolism.
Topics: Animals; Carboxy-Lyases; Cell Line; Cyclohexanecarboxylic Acids; Cyclohexenes; Cyclohexylamines; gam | 1982 |
Intrahepatic polyamine levels during rat liver carcinogenesis induced by N-2-fluorenylacetamide.
Topics: 2-Acetylaminofluorene; Animals; Body Weight; Female; Liver Neoplasms; Neoplasms, Experimental; Organ | 1981 |
Urinary putrescine and plasma lactate dehydrogenase as markers of experimental adenocarcinoma growth.
Topics: Adenocarcinoma; Animals; Creatinine; L-Lactate Dehydrogenase; Male; Neoplasms, Experimental; Putresc | 1981 |
Effects of DL-alpha-methylornithine on proliferation and polyamine content of 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cell Division; Cells, Cultured; Neoplasms, Experimental; O | 1980 |
Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours.
Topics: Animals; Erythrocytes; Female; Humans; Male; Melanoma; Mice; Mice, Inbred DBA; Middle Aged; Neoplasm | 1980 |
Effects on tumor induction, growth, metastasis and histology of concurrent administration of putrescine and its metabolizing inhibitor alpha-difluoromethylornithine in nickel tumorigenesis in soft tissue.
Topics: Animals; Cell Differentiation; Eflornithine; Female; Neoplasms, Experimental; Nickel; Polyamines; Pu | 1994 |
Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Animals; Animals, Genetically Modified; Carcin | 2002 |
Differential transglutaminase distribution in normal rat liver and rat hepatoma.
Topics: Animals; Binding Sites; Carcinoma, Hepatocellular; Centrifugation, Density Gradient; Cytoplasm; Fema | 1976 |
Synthesis and accumulation of polyamines in rat liver during chemical carcinogenesis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carcinogens; Glucagon; Growth Hormone; Hydrocortisone; Li | 1978 |
Prevention of 3,4-benzopyrene carcinogenesis in presence of putrescine.
Topics: Animals; Benzopyrenes; Cell Nucleus; Female; Mice; Mitosis; Neoplasms, Experimental; Putrescine | 1976 |
Changes in serum putrescine and spermidine levels following local radiation to hepatoma 3924A of the rat.
Topics: Animals; Carcinoma, Hepatocellular; Female; Liver Neoplasms; Neoplasms, Experimental; Putrescine; Ra | 1976 |
The appearance of an ornithine decarboxylase inhibitory protein upon the addition of putrescine to cell cultures.
Topics: Carboxy-Lyases; Carcinoma, Hepatocellular; Cell Line; Culture Media; Cycloheximide; Dactinomycin; Ki | 1976 |
Changes in polyamine levels and protein synthesis rate during rat liver carcinogenesis induced by 4-dimethylaminoazobenzene.
Topics: Animals; Carcinoma, Hepatocellular; Liver Neoplasms; Male; Neoplasm Proteins; Neoplasms, Experimenta | 1978 |
Ornithine as a possible marker of cancer.
Topics: Animals; Neoplasms, Experimental; Ornithine; Putrescine; Rats | 1979 |
Depletion of intracellular putrescine and spermidine by alpha-difluromethylornithine does not inhibit proliferation of 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cell Division; Depression, Chemical; Dose-Response Relatio | 1979 |
Increase of urinary putrescine in 3,4-benzopyrene carcinogenesis and its inhibition by putrescine.
Topics: Animals; Benzopyrenes; Female; Mice; Neoplasms, Experimental; Putrescine | 1978 |
[Prevention of 3,4-benzpyrene carcinogenesis by naturally occurring and synthetic compounds].
Topics: Aconitic Acid; Animals; Antineoplastic Agents; Benzopyrenes; Cadaverine; Carcinogens; Cysteine; Dica | 1975 |
Carbon-11-labeled methylated polyamine analogs: uptake in prostate and tumor in animal models.
Topics: Animals; Carbon Radioisotopes; Dogs; Male; Melanoma; Methylation; Mice; Neoplasm Transplantation; Ne | 1977 |
Acetyl-coenzyme A: 1,4-diaminobutane N-acetyltransferase: activity in rat brain during development, in experimental brain tumours and in brains of fish of different metabolic activity.
Topics: Acetyltransferases; Aging; Animals; Brain; Brain Neoplasms; Butylamines; Cell Nucleus; Diamines; Gli | 1975 |
More sensitive automated detection of polyamines in physiological fluids and tissue extracts with omicron-phthalaldehyde.
Topics: Aldehydes; Amniotic Fluid; Animals; Autoanalysis; Brain Neoplasms; Evaluation Studies as Topic; Fema | 1975 |
Putrescine as inhibitor of 3,4-benzopyrene cancerogenesis.
Topics: Animals; Benzopyrenes; Female; Mice; Neoplasms, Experimental; Putrescine | 1975 |
Urinary putrescine, spermidine, and spermine in human blood and solid cancers and in an experimental gastric tumor of rats.
Topics: Animals; Female; Humans; Leukemia; Lymphoma; Methylnitronitrosoguanidine; Neoplasms; Neoplasms, Expe | 1976 |
Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine.
Topics: 1,2-Dimethylhydrazine; Acetyltransferases; Adenocarcinoma; Animals; Base Sequence; Carcinogens; Colo | 1990 |
Inhibitory action of alpha-difluoromethylornithine on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat urinary bladder carcinogenesis.
Topics: Animals; Butylhydroxybutylnitrosamine; Drug Administration Schedule; Eflornithine; Male; Neoplasms, | 1989 |
Chain-fluorinated polyamines as tumour markers. III. Determination of geminal difluoropolyamines and their precursor 2,2-difluoroputrescine in normal tissues and experimental tumours by in vitro and in vivo 19F NMR spectroscopy.
Topics: Animals; Biomarkers, Tumor; Liver; Magnetic Resonance Spectroscopy; Mice; Neoplasm Transplantation; | 1988 |
Putrescine and its biosynthetic precursor L-ornithine augment the in vivo immunization against minor histocompatibility antigens and syngeneic tumor cells.
Topics: Animals; Cytotoxicity, Immunologic; Histocompatibility Antigens; Immunization; Interleukin-2; Mice; | 1986 |
Relationship of erythrocyte polyamine levels and growth rate of transplantable tumors in rats.
Topics: Animals; Colonic Neoplasms; Fibrosarcoma; Hematocrit; Male; Neoplasms, Experimental; Polyamines; Put | 1986 |
[Effect of blood serum proteins and glucose on the polyamine content of the liver of rats with Guérin's carcinoma].
Topics: Animals; Blood Proteins; Drug Evaluation, Preclinical; Glucose; Liver; Neoplasm Transplantation; Neo | 1986 |
Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine.
Topics: Animals; Carboxy-Lyases; Carcinoma, Hepatocellular; Electrophoresis, Paper; Liver; Liver Neoplasms; | 1972 |
Polyamine depletion of tumor tissue and subsequent elevation of spermidine in the sera of rats with 3924A hepatomas after 5-fluorouracil administration.
Topics: Animals; Carcinoma, Hepatocellular; Female; Fluorouracil; Liver; Liver Neoplasms; Neoplasms, Experim | 1974 |
Transglutaminase and tumor growth.
Topics: Animals; Blood Coagulation; Cross Reactions; Dipeptides; Glutamine; Glycine; Glycosides; Guinea Pigs | 1972 |
Polyamine metabolism in tumor, spleen and liver of tumor-bearing rats.
Topics: Animals; Body Weight; Brain Neoplasms; Carbon Radioisotopes; Carboxy-Lyases; Liver; Male; Neoplasm T | 1974 |
An automated micromethod for the quantitative analysis of di- and polyamines utilizing a sensitive high pressure liquid chromatographic procedure.
Topics: Animals; Autoanalysis; Brain; Brain Chemistry; Brain Neoplasms; Cadaverine; Carbon Radioisotopes; Ch | 1974 |