putrescine has been researched along with Experimental Hepatoma in 41 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 7.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "Our previous study showed that treatment of highly invasive rat ascites hepatoma (LC-AH) cells with alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase, decreased both their intracellular level of putrescine and their in vitro invasion of a monolayer of calf pulmonary arterial endothelial (CPAE) cells, and that both these decreases were completely reversed by exogenous putrescine, but not spermidine or spermine." | 3.70 | Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells. ( Ashida, Y; Inoue, H; Miwa, Y; Miyoshi, K; Ueno, A, 1998) |
| "Isogabaculine (3-amino-1,3-cyclohexadienyl carboxylic acid; RMI 71,932), an irreversible inhibitor of GABA transaminase, when added to mouse neuroblastoma cells in spinner culture at the time of induction of cell proliferation, increased ornithine decarboxylase (ODC) activity threefold above that of normal control cells and twofold above that of GABA (gamma-aminobutyric acid)-treated cells." | 3.66 | Effect of GABA and isogabaculine on ornithine decarboxylase and putrescine metabolism. ( Diekema, KA; Lippert, BJ; McCann, PP, 1982) |
| "Putrescine itself was found to have a Ki = 2." | 1.28 | Modulation of insulin induced ornithine decarboxylase by putrescine and methylputrescines in H-35 hepatoma cells. ( Dellacha, JM; Frydman, J; Frydman, RB; Robetto, E; Ruiz, O, 1991) |
| "Putrescine was increased and spermidine was decreased, consistent with the inhibition of spermidine synthase by this compound, which is a potent and specific "transition-state analogue inhibitor" of the isolated enzyme in vitro." | 1.26 | Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism. ( Coward, JK; Pegg, AE; Tang, KC, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 30 (73.17) | 18.7374 |
| 1990's | 11 (26.83) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moyano, N | 1 |
| Frydman, J | 2 |
| Buldain, G | 2 |
| Ruiz, O | 2 |
| Frydman, RB | 2 |
| Albano, E | 2 |
| Poli, G | 2 |
| Chiarpotto, E | 2 |
| Gravela, E | 2 |
| Pegg, AE | 3 |
| Tang, KC | 1 |
| Coward, JK | 1 |
| Potter, VR | 1 |
| Evanson, TR | 1 |
| Gayda, DP | 1 |
| Gurr, JA | 1 |
| Rudkin, BB | 1 |
| Mamont, PS | 5 |
| Seiler, N | 4 |
| Siat, M | 2 |
| Joder-Ohlenbusch, AM | 2 |
| Bernhardt, A | 1 |
| Casara, P | 1 |
| Wu, VS | 2 |
| Byus, CV | 3 |
| Byczkowski, JZ | 1 |
| Porter, CW | 1 |
| Bartholeyns, J | 1 |
| Bouclier, M | 1 |
| Sessa, A | 1 |
| Desiderio, MA | 2 |
| Baizini, M | 1 |
| Perin, A | 1 |
| Paradisi, L | 1 |
| Danzin, C | 1 |
| Wagner, J | 1 |
| Claverie, N | 1 |
| Pritchard, ML | 1 |
| Jefferson, LS | 1 |
| Diekema, KA | 1 |
| McCann, PP | 5 |
| Lippert, BJ | 1 |
| Tardif, C | 2 |
| Diekema, K | 1 |
| Comolli, R | 1 |
| Riboni, L | 1 |
| Canellakis, ZN | 1 |
| Winstead, MB | 1 |
| Dischino, DD | 1 |
| Munder, NA | 1 |
| Walsh, C | 1 |
| Winchell, HS | 1 |
| Shipe, JR | 1 |
| Savory, J | 1 |
| Wills, MR | 1 |
| Rowley, R | 1 |
| Looney, WB | 1 |
| Hopkins, HA | 1 |
| Tome, ME | 1 |
| Fiser, SM | 1 |
| Gerner, EW | 2 |
| Fedoronchuk, TV | 1 |
| Siatkin, SP | 1 |
| Lulle, IZh | 1 |
| Ianson, IaIa | 1 |
| Lidak, MIu | 1 |
| Berezov, TT | 1 |
| Hawel, L | 1 |
| Tjandrawinata, RR | 1 |
| Shimpo, K | 1 |
| Takahashi, H | 1 |
| Tsuda, H | 1 |
| Hibino, T | 1 |
| Kawai, K | 1 |
| Kimura, C | 1 |
| Nagatsu, T | 1 |
| Fujita, K | 2 |
| Tacchini, L | 1 |
| Anzon, E | 1 |
| Pogliaghi, G | 1 |
| Radice, L | 1 |
| Bernelli-Zazzera, A | 1 |
| Ashida, Y | 2 |
| Ueno, A | 1 |
| Miwa, Y | 1 |
| Miyoshi, K | 1 |
| Inoue, H | 2 |
| Aizencang, G | 1 |
| Harari, P | 1 |
| Guerra, L | 1 |
| Pickart, M | 1 |
| Hernandez, P | 1 |
| Frydman, B | 1 |
| Hornsperger, JM | 2 |
| Böhlen, P | 1 |
| Kido, J | 1 |
| Kinoshita, F | 1 |
| Nishino, M | 1 |
| Shinkai, K | 1 |
| Akedo, H | 1 |
| Robetto, E | 1 |
| Dellacha, JM | 1 |
| Feo, F | 1 |
| Garcea, R | 1 |
| Daino, L | 1 |
| Pascale, R | 1 |
| Pirisi, L | 1 |
| Frassetto, S | 1 |
| Ruggiu, ME | 1 |
| Baillon, JG | 1 |
| Kolb, M | 1 |
| Quemener, V | 1 |
| Moulinoux, JP | 1 |
| Berdinskikh, NK | 1 |
| Lialiushko, NM | 1 |
| Sarhan, S | 2 |
| Knodgen, B | 1 |
| Gerhart, F | 1 |
| Dezeure, F | 1 |
| Murakami, Y | 2 |
| Kameji, T | 1 |
| Hayashi, S | 2 |
| Mitchell, JL | 1 |
| Mahan, DW | 1 |
| Qasba, P | 1 |
41 other studies available for putrescine and Experimental Hepatoma
| Article | Year |
|---|---|
Inhibition of ornithine decarboxylase by the isomers of 1,4-dimethylputrescine.
Topics: Animals; Cell Line; Female; Isomerism; Liver; Liver Neoplasms, Experimental; Neoplasm Proteins; Opti | 1990 |
Effect of aldehydes on polyamine metabolism. II. Methylglyoxal-induced changes in S-adenosylmethionine decarboxylase (SAMD) activity and RNA synthesis and degradation in isolated hepatocytes.
Topics: Adenosylmethionine Decarboxylase; Aldehydes; Animals; Carboxy-Lyases; Liver; Liver Neoplasms, Experi | 1981 |
Effects of S-adenosyl-1,8-diamino-3-thiooctane on polyamine metabolism.
Topics: Adenosine; Animals; Cell Transformation, Viral; Cells, Cultured; Fibroblasts; Liver Neoplasms, Exper | 1982 |
Cultured hepatoma cells for the study of enzyme regulation: induction of ornithine decarboxylase by insulin and asparagine.
Topics: Animals; Asparagine; Cell Division; Cells, Cultured; Culture Media; Enzyme Induction; Growth Substan | 1984 |
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells.
Topics: Animals; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; Cycloheximide; Eflornithi | 1984 |
Effects of (2R, 5R)-6-heptyne-2,5-diamine, a potent inhibitor of L-ornithine decarboxylase, on rat hepatoma cells cultured in vitro.
Topics: Adenosylmethionine Decarboxylase; Alkynes; Animals; Cell Division; Cell Survival; Cells, Cultured; D | 1984 |
A role for ornithine in the regulation of putrescine accumulation and ornithine decarboxylase activity in Reuber H35 hepatoma cells.
Topics: Animals; Arginase; Arginine; Cell Adhesion; Cells, Cultured; Dose-Response Relationship, Drug; Enzym | 1984 |
Interactions between bis(guanylhydrazones) and polyamines in isolated mitochondria.
Topics: Animals; Antineoplastic Agents; Carbanilides; Dinitrophenols; Drug Interactions; Guanidines; In Vitr | 1983 |
Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase.
Topics: Animals; Antineoplastic Agents; Carboxy-Lyases; Cimetidine; Female; Histamine; Histidine; Histidine | 1984 |
Diamine oxidase activity in regenerating rat liver and in 4-dimethylaminoazobenzene-induced and Yoshida AH 130 hepatomas.
Topics: Acetaldehyde; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Amine Oxidase (Copper-Containing); A | 1981 |
Effect of aldehydes on polyamine metabolism. I. Method used to determine CO2 produced "in vitro" in enzymatic reactions: its application in evaluation of S-adenosylmethionine decarboxylase (SAMD) activity.
Topics: Adenosylmethionine Decarboxylase; Animals; Carbon Dioxide; Carboxy-Lyases; Liver; Liver Neoplasms, E | 1981 |
Accumulation of decarboxylated S-adenosyl-L-methionine in mammalian cells as a consequence of the inhibition of putrescine biosynthesis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cells, Cultured; Eflornithine; Liver Neop | 1982 |
Ornithine decarboxylase from hepatoma cells and a variant cell line in which the enzyme is more stable.
Topics: Animals; Carboxy-Lyases; Cytosol; Drug Stability; Genetic Variation; Half-Life; Kinetics; Liver Neop | 1982 |
Effect of GABA and isogabaculine on ornithine decarboxylase and putrescine metabolism.
Topics: Animals; Carboxy-Lyases; Cell Line; Cyclohexanecarboxylic Acids; Cyclohexenes; Cyclohexylamines; gam | 1982 |
The dual action of the non-physiological diamines 1,3 diaminopropane and cadaverine on ornithine decarboxylase of HTC cells.
Topics: Animals; Cadaverine; Carboxy-Lyases; Cells, Cultured; Diamines; Enzyme Induction; Guinea Pigs; In Vi | 1980 |
Reassociation of eukaryotic ribosomal subunits and polyamine concentration in Yoshida ascites hepatoma and Ehrlich ascites carcinoma cells during growth.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Liver Neoplasms, Experimental; Mice; Polyamines; Putre | 1980 |
Effects of acetylated polyamines on ornithine decarboxylase in rat HTC cells.
Topics: Animals; Carboxy-Lyases; Kinetics; Liver Neoplasms, Experimental; Ornithine Decarboxylase; Putrescin | 1981 |
Relationship of molecular structure to in vivo distribution of carbon-11-labeled compounds. VI. Carbon-11-labeled aliphatic diamines.
Topics: Animals; Carbon Radioisotopes; Diamines; Female; Liver Neoplasms, Experimental; Male; Prostate; Putr | 1980 |
Erythrocyte polyamine levels in rats with H4IIE hepatomas before and after radiation treatment.
Topics: Animals; Buffers; Erythrocytes; Liver Neoplasms, Experimental; Neoplasm Transplantation; Polyamines; | 1980 |
Consequences of aberrant ornithine decarboxylase regulation in rat hepatoma cells.
Topics: Amine Oxidase (Copper-Containing); Animals; Calcium; Cell Cycle; Cell Division; Cell Survival; Drug | 1994 |
[The effect of chemically modified polyamine analogs on polyamine and putrescine biosynthesis in a cell-free test system from a rat hepatoma].
Topics: Animals; Antineoplastic Agents; Biogenic Polyamines; Cell-Free System; Eflornithine; Liver Neoplasms | 1993 |
Selective putrescine export is regulated by insulin and ornithine in Reuber H35 hepatoma cells.
Topics: Animals; Biological Transport; Culture Media; Insulin; Liver Neoplasms, Experimental; Ornithine; Put | 1994 |
Inhibition of hepatocellular carcinoma development and erythrocyte polyamine levels in ODS rats fed on 3'-methyl-4-dimethylaminoazobenzene by hemicalcium ascorbate, 2-O-octadecylascorbic acid, and ascorbyl palmitate.
Topics: Animals; Antimutagenic Agents; Ascorbic Acid; Body Weight; Carcinogens; Erythrocytes; Free Radical S | 1996 |
Effects of polyamine imbalance on the induction of stress genes in hepatocarcinoma cells exposed to heat shock.
Topics: Animals; Cell Division; Eflornithine; Gene Expression Regulation, Neoplastic; Genes, fos; Genes, Imm | 1996 |
Putrescine-stimulated intracellular Ca2+ release for invasiveness of rat ascites hepatoma cells.
Topics: Animals; Ascites; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Carcinoma, Hepatocell | 1998 |
Antiproliferative effects of N1,N4-dibenzylputrescine in human and rodent tumor cells.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cadaverine; Carcinoma, Squamous Cell; Cell Division; Diam | 1998 |
Two distinct mechanisms for ornithine decarboxylase regulation by polyamines in rat hepatoma cells.
Topics: Animals; Carboxy-Lyases; Clone Cells; Cycloheximide; Dose-Response Relationship, Drug; Drug Therapy, | 1979 |
Regulatory interrelations between GABA and polyamines. II. Effect of GABA on ornithine decarboxylase and putrescine levels in cell culture.
Topics: Aminocaproates; Animals; Asparagine; Carboxy-Lyases; Cells, Cultured; gamma-Aminobutyric Acid; Gluta | 1979 |
Putrescine-dependent invasive capacity of rat ascites hepatoma cells.
Topics: Animals; Ascites; Biogenic Polyamines; Cattle; Cells, Cultured; Eflornithine; Endothelium, Vascular; | 1992 |
The level of substrate ornithine can alter polyamine-dependent DNA synthesis following phorbolester stimulation of cultured hepatoma cells.
Topics: Animals; Arginine; Blood; Clone Cells; Culture Media; DNA; Eflornithine; Insulin; Liver Neoplasms, E | 1991 |
Modulation of insulin induced ornithine decarboxylase by putrescine and methylputrescines in H-35 hepatoma cells.
Topics: Animals; Dactinomycin; DNA; Enzyme Activation; Insulin; Kinetics; Liver; Liver Neoplasms, Experiment | 1991 |
Early stimulation of polyamine biosynthesis during promotion by phenobarbital of diethylnitrosamine-induced rat liver carcinogenesis. The effects of variations of the S-adenosyl-L-methionine cellular pool.
Topics: 2-Acetylaminofluorene; Animals; Diethylnitrosamine; Enzyme Induction; gamma-Glutamyltransferase; Kin | 1985 |
Inhibition of mammalian spermine synthase by N-alkylated-1,3-diaminopropane derivatives in vitro and in cultured rat hepatoma cells.
Topics: Animals; Cattle; Cells, Cultured; Diamines; Liver Neoplasms, Experimental; Putrescine; Rats; Spermid | 1989 |
[Scanning electron microscopic demonstration of putrescine receptor sites on the surface of cancerous hepatocytes in culture].
Topics: Animals; Cell Division; Cell Membrane; Cells, Cultured; Escherichia coli Proteins; Latex; Liver Neop | 1985 |
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation.
Topics: Alkynes; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Liver Neoplasms, Experimen | 1986 |
[Polyamine levels and diamine oxidase activity in the rat liver and kidneys during hepatocarcinogenesis induced by N-nitrosodiethylamine].
Topics: Amine Oxidase (Copper-Containing); Animals; Diethylamines; Diethylnitrosamine; Kidney; Liver; Liver | 1987 |
Chain-fluorinated polyamines as tumor markers--I. In vivo transformation of 2,2-difluoroputrescine into 6,6-difluorospermidine and 6,6-difluorospermine.
Topics: Animals; Biomarkers, Tumor; Biotransformation; Cattle; Cell Division; Eflornithine; Female; Liver Ne | 1987 |
Chain-fluorinated polyamines as tumor markers--IV. Comparison of 2-fluoroputrescine and 2,2-difluoroputrescine as substrates of spermidine synthase in vitro and in vivo.
Topics: Animals; Binding Sites; Biomarkers, Tumor; Dose-Response Relationship, Drug; In Vitro Techniques; Li | 1988 |
Accumulation of ornithine decarboxylase-antizyme complex in HMOA cells.
Topics: Animals; Cells, Cultured; Chemical Precipitation; Chromatography, Gel; Cycloheximide; Eflornithine; | 1985 |
Dicyclohexylamine effects on HTC cell polyamine content and ornithine decarboxylase activity.
Topics: Animals; Cell Division; Cells, Cultured; Cyclohexylamines; Liver Neoplasms, Experimental; Mitoguazon | 1985 |
Role of antizyme in degradation of ornithine decarboxylase in HTC cells.
Topics: Animals; Cells, Cultured; Cycloheximide; Dactinomycin; Half-Life; Liver Neoplasms, Experimental; Mac | 1985 |