putrescine has been researched along with Cell Transformation, Neoplastic in 28 studies
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The urinary polyamines putrescine and spermindine were evaluated in a population of 49 patients with malignant lymphomas (40 with non-Hodgkin's lymphoma and 9 with Hodgkin's disease)." | 3.66 | Polyamines in lymphomas: their value in disease staging and monitoring of therapy efficiency. ( Cambon, P; Cassuto, JP; Lalanne, CM; Lesbats, G; Milano, G; Schneider, M; Viguier, E, 1980) |
| "Chemoprevention is the long-term use of different chemical agents, both synthetic and natural, to prevent or delay the onset of disease." | 2.50 | Pharmacological and dietary agents for colorectal cancer chemoprevention: effects on polyamine metabolism (review). ( Linsalata, M; Orlando, A; Russo, F, 2014) |
| "Putrescine transport was inhibited to varying degrees by other polyamines, but not by amino acids or divalent cations." | 1.26 | Putrescine transport is greatly increased in human fibroblasts initiated to proliferate. ( Pohjanpelto, P, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (60.71) | 18.7374 |
| 1990's | 8 (28.57) | 18.2507 |
| 2000's | 2 (7.14) | 29.6817 |
| 2010's | 1 (3.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Linsalata, M | 1 |
| Orlando, A | 1 |
| Russo, F | 1 |
| Gervais, A | 1 |
| Levêque, J | 1 |
| Bouet-Toussaint, F | 1 |
| Burtin, F | 1 |
| Lesimple, T | 1 |
| Sulpice, L | 1 |
| Patard, JJ | 1 |
| Genetet, N | 1 |
| Catros-Quemener, V | 1 |
| Medrano, EE | 1 |
| Goldemberg, SH | 1 |
| Algranati, ID | 1 |
| Sugiura, M | 1 |
| Shafman, T | 1 |
| Mitchell, T | 1 |
| Griffin, J | 1 |
| Kufe, D | 1 |
| Heby, O | 2 |
| Oredsson, SM | 2 |
| Kanje, M | 1 |
| Milano, G | 1 |
| Cassuto, JP | 1 |
| Schneider, M | 1 |
| Viguier, E | 1 |
| Lesbats, G | 1 |
| Cambon, P | 1 |
| Lalanne, CM | 1 |
| O'Brien, TG | 3 |
| Saladik, D | 1 |
| Diamond, L | 2 |
| Morrison, RF | 1 |
| Seidel, ER | 1 |
| Auvinen, M | 1 |
| Peralta Soler, A | 1 |
| Gilliard, G | 1 |
| Megosh, L | 1 |
| George, K | 1 |
| Dai, H | 1 |
| Kramer, DL | 1 |
| Yang, C | 1 |
| Murti, KG | 1 |
| Porter, CW | 1 |
| Cleveland, JL | 1 |
| Tabib, A | 1 |
| Bachrach, U | 5 |
| Hardin, MS | 1 |
| Mader, R | 1 |
| Hurta, RA | 1 |
| Birckbichler, PJ | 1 |
| Orr, GR | 1 |
| Conway, E | 1 |
| Patterson, MK | 1 |
| Don, S | 4 |
| Wiener, H | 3 |
| Quash, G | 1 |
| Calogero, H | 1 |
| Fossar, N | 1 |
| Ferdinand, A | 1 |
| Taylor, D | 1 |
| Pohjanpelto, P | 1 |
| Isom, HC | 1 |
| Backstrom, JT | 1 |
| Clark, JL | 1 |
| Fuller, JL | 1 |
| Tatsuta, M | 1 |
| Iishi, H | 1 |
| Baba, M | 1 |
| Ichii, M | 1 |
| Nakaizumi, A | 1 |
| Uehara, H | 1 |
| Taniguchi, H | 1 |
| Sen, U | 1 |
| Guha, S | 1 |
| Glikman, PL | 1 |
| Manni, A | 1 |
| Bartholomew, M | 1 |
| Demers, L | 1 |
| Billgren, M | 1 |
| Lembach, KJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563] | Phase 2 | 70 participants (Anticipated) | Interventional | 2023-03-14 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for putrescine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Pharmacological and dietary agents for colorectal cancer chemoprevention: effects on polyamine metabolism (review).
Topics: Anticarcinogenic Agents; Cell Transformation, Neoplastic; Chemoprevention; Colorectal Neoplasms; Hum | 2014 |
27 other studies available for putrescine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Dendritic cells are defective in breast cancer patients: a potential role for polyamine in this immunodeficiency.
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, No | 2005 |
Differential effect of alpha-difluoromethyl-ornithine on the proliferation of Balb 3T3 and chemically transformed 3T3 cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; | 1983 |
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Hu | 1984 |
Polyamine biosynthetic enzymes as targets in cancer chemotherapy.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; Cell Transformatio | 1984 |
Polyamines in lymphomas: their value in disease staging and monitoring of therapy efficiency.
Topics: Cell Transformation, Neoplastic; Humans; Longitudinal Studies; Lymphoma; Neoplasm Staging; Polyamine | 1980 |
Regulation of polyamine biosynthesis in normal and transformed hamster cells in culture.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Cricetinae; Enzyme Induction; Fibroblasts; Orni | 1980 |
Cell spreading and the regulation of ornithine decarboxylase.
Topics: Cell Adhesion; Cell Count; Cell Division; Cell Line; Cell Movement; Cell Transformation, Neoplastic; | 1995 |
Cell transformation, invasion, and angiogenesis: a regulatory role for ornithine decarboxylase and polyamines?
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Transformation, Neoplastic; Mice; Neopla | 1997 |
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcin | 1998 |
The polyamine oxidase inhibitor MDL-72,527 selectively induces apoptosis of transformed hematopoietic cells through lysosomotropic effects.
Topics: Animals; Apoptosis; bcl-X Protein; Cell Cycle; Cell Death; Cell Line, Transformed; Cell Survival; Ce | 1999 |
Role of polyamines in mediating malignant transformation and oncogene expression.
Topics: 3T3 Cells; Animals; Biogenic Polyamines; Cell Division; Cell Line; Cell Transformation, Neoplastic; | 1999 |
K-FGF mediated transformation and induction of metastatic potential involves altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression--role in cellular invasion.
Topics: 3T3 Cells; Adenosylmethionine Decarboxylase; Animals; Cell Transformation, Neoplastic; Collagen; Fib | 2002 |
Transglutaminase activity in normal and transformed cells.
Topics: Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; gamma-Glutamyltransferase; Putresci | 1977 |
Specific increase in polyamine levels in chick embryo cells transformed by Rous sarcoma virus.
Topics: Allantois; Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Chick Embryo; Chorion; E | 1975 |
Polyamine metabolism in normal and in virus-transformed chick embryo fibroblasts.
Topics: Avian Sarcoma Viruses; Carboxy-Lyases; Cell Transformation, Neoplastic; Cells, Cultured; Mutation; O | 1975 |
Modification of diamine oxidase activity in vitro by metabolites of asparagine and differences in asparagine decarboxylation in normal and virus-transformed baby hamster kidney cells.
Topics: Alanine; Amides; Amine Oxidase (Copper-Containing); Asparagine; Cell Line; Cell Transformation, Neop | 1976 |
Putrescine transport is greatly increased in human fibroblasts initiated to proliferate.
Topics: Biological Transport; Blood; Bucladesine; Cadaverine; Calcium; Cell Division; Cell Line; Cell Transf | 1976 |
Aberrant regulation of ornithine decarboxylase by serum, putrescine, and spermidine in cytomegalovirus-transformed human cells.
Topics: Carboxy-Lyases; Cell Transformation, Neoplastic; Cells, Cultured; Culture Media; Cytomegalovirus; Di | 1979 |
Ornithine decarboxylase induction and DNA synthesis in hamster embryo cell cultures treated with tumor-promoting phorbol diesters.
Topics: Carboxy-Lyases; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA; Enzyme Inducti | 1977 |
Protein inhibitor of ornithine decarboxylase does not account for effect of putrescine on 3T3 cells.
Topics: Carboxy-Lyases; Cell Line; Cell Transformation, Neoplastic; Fibroblasts; Humans; Neoplasm Proteins; | 1976 |
Inhibition by putrescine of experimental carcinogenesis in rat colon induced by azoxymethane.
Topics: Adenocarcinoma; Adenoma; Animals; Azoxymethane; Body Weight; Carcinoma in Situ; Cell Transformation, | 1991 |
The role of polyamines as a marker of tumor progression and regression in experimental tumors.
Topics: Animals; Biomarkers, Tumor; Carcinoma, Ehrlich Tumor; Cell Division; Cell Transformation, Neoplastic | 1990 |
Polyamine involvement in basal and estradiol-stimulated insulin-like growth factor I secretion and action in breast cancer cells in culture.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Transformation, Neoplastic; Eflornithine; Estradiol; | 1990 |
Induction of F9 embryonal carcinoma cell differentiation by inhibition of polyamine synthesis.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromat | 1985 |
Polyamines and tumor cells: effect of transformation of chick embryo fibroblasts by Rous sarcoma virus on polyamine levels.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Chro | 1973 |
Polyamines in normal and in virus-transformed chick embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Neoplastic; Cells, Cultured; Chick Embryo; Cult | 1974 |
Regulation of growth in vitro. I. Control of ornithine decarboxylase levels in untransformed and transformed mouse fibroblasts by serum.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; Cell Transformation, Neoplastic; Cells, Cultured; Cul | 1974 |