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putrescine and Cancer of Skin

putrescine has been researched along with Cancer of Skin in 16 studies

Research Excerpts

ExcerptRelevanceReference
"The ethyl acetate extract of the acetone-soluble Aloe arborescens fraction was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema, putrescine increase and tumour promotion in mouse skin."7.71Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin. ( Beppu, H; Chihara, T; Ida, C; Kaneko, T; Kuzuya, H; Shimpo, K, 2002)
"As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent."7.69Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. ( Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E, 1995)
"The ethyl acetate extract of the acetone-soluble Aloe arborescens fraction was found to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ear oedema, putrescine increase and tumour promotion in mouse skin."3.71Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin. ( Beppu, H; Chihara, T; Ida, C; Kaneko, T; Kuzuya, H; Shimpo, K, 2002)
"As a result of bioassay-guided fractionation, betulinic acid, a pentacyclic triterpene, was identified as a melanoma-specific cytotoxic agent."3.69Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. ( Beecher, CW; Brown, DM; Chagwedera, TE; Chai, H; Cordell, GA; Farnsworth, NR; Fong, HH; Kinghorn, AD; Lee, IS; Pisha, E, 1995)
"Putrescine was decreased in MEK/AZ tumors, while spermidine and spermine levels were unaffected, suggesting that the primary role played by AZ in this system is to inhibit putrescine accumulation."1.33Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis. ( Feith, DJ; Origanti, S; Sass-Kuhn, S; Shantz, LM; Shoop, PL, 2006)
"However, DFMO treatment led to marked hair loss in PKC epsilon transgenic mice."1.32Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. ( Ness, KJ; Oberley, TD; Verma, AK; Wheeler, DL, 2003)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19903 (18.75)18.7374
1990's6 (37.50)18.2507
2000's6 (37.50)29.6817
2010's1 (6.25)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hayes, CS1
DeFeo-Mattox, K1
Woster, PM1
Gilmour, SK1
Shimpo, K1
Ida, C1
Chihara, T1
Beppu, H1
Kaneko, T1
Kuzuya, H1
Wheeler, DL1
Ness, KJ1
Oberley, TD1
Verma, AK3
García-Fernández, AJ1
Rodríguez, RA1
Pérez-Pertejo, Y1
Balaña-Fouce, R1
Feith, DJ1
Origanti, S1
Shoop, PL1
Sass-Kuhn, S1
Shantz, LM1
Takigawa, M1
Simsiman, RC1
Boutwell, RK2
Weekes, RG1
Pisha, E1
Chai, H1
Lee, IS1
Chagwedera, TE1
Farnsworth, NR1
Cordell, GA1
Beecher, CW1
Fong, HH1
Kinghorn, AD1
Brown, DM1
Savouré, N1
Briand, G1
Amory-Touz, MC1
Combre, A1
Maudet, M1
Nicol, M1
O'Brien, TG3
Megosh, LC2
Gilliard, G2
Soler, AP1
Peralta Soler, A1
Megosh, L1
George, K1
Arbeit, JM1
Riley, RR1
Huey, B1
Porter, C1
Kelloff, G1
Lubet, R1
Ward, JM1
Pinkel, D1
Pietilä, M1
Parkkinen, JJ1
Alhonen, L1
Jänne, J1
Coleman, CS1
Pegg, AE1
Guo, Y1
Sawicki, JA1
Pavel, P1
Schwippelová, Z1
Gonzalez, GG1
Byus, CV1

Reviews

1 review available for putrescine and Cancer of Skin

ArticleYear
[Polyamines and malignant melanoma (author's transl)].
    Ceskoslovenska dermatologie, 1979, Volume: 54, Issue:2

    Topics: Animals; Humans; Mammals; Melanoma; Polyamines; Putrescine; Skin Neoplasms; Spermidine; Spermine

1979

Other Studies

15 other studies available for putrescine and Cancer of Skin

ArticleYear
Elevated ornithine decarboxylase activity promotes skin tumorigenesis by stimulating the recruitment of bulge stem cells but not via toxic polyamine catabolic metabolites.
    Amino acids, 2014, Volume: 46, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Hair

2014
Aloe arborescens extract inhibits TPA-induced ear oedema, putrescine increase and tumour promotion in mouse skin.
    Phytotherapy research : PTR, 2002, Volume: 16, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aloe; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Ea

2002
Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss.
    Cancer research, 2003, Jun-15, Volume: 63, Issue:12

    Topics: Administration, Oral; Alopecia; Animals; Benz(a)Anthracenes; Carcinogens; Carcinoma, Squamous Cell;

2003
Characterization of putrescine uptake in hamster amelanocytic melanoma AMEL-3 cells.
    Molecules and cells, 2005, Aug-31, Volume: 20, Issue:1

    Topics: Amidines; Animals; Biological Transport; Cell Cycle; Cricetinae; Dose-Response Relationship, Drug; D

2005
Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis.
    Carcinogenesis, 2006, Volume: 27, Issue:5

    Topics: Animals; Cell Cycle; Cell Proliferation; MAP Kinase Kinase Kinases; Mice; Mice, Inbred C57BL; Mice,

2006
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
    Biochemical and biophysical research communications, 1982, Apr-14, Volume: 105, Issue:3

    Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics;

1982
Inhibition by putrescine of the induction of epidermal ornithine decarboxylase activity and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
    Cancer research, 1980, Volume: 40, Issue:11

    Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cocarcinogenesis; Enzyme Induction; Epide

1980
Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis.
    Nature medicine, 1995, Volume: 1, Issue:10

    Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Betulinic Acid; DNA Damage; Growth Inhibitors

1995
Vitamin A status and metabolism of cutaneous polyamines in the hairless mouse after UV irradiation: action of beta-carotene and astaxanthin.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1995, Volume: 65, Issue:2

    Topics: Animals; beta Carotene; Carotenoids; Epidermis; Female; Food, Fortified; Liver; Mice; Mice, Hairless

1995
Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin.
    Cancer research, 1997, Jul-01, Volume: 57, Issue:13

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Age Factors; Animals; Animals, Newborn; Benzo(a)pyrene; Hair Folli

1997
Polyamines regulate expression of the neoplastic phenotype in mouse skin.
    Cancer research, 1998, Apr-15, Volume: 58, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Apoptosis; Carcinoma, Papillary; Carcin

1998
Difluoromethylornithine chemoprevention of epidermal carcinogenesis in K14-HPV16 transgenic mice.
    Cancer research, 1999, Aug-01, Volume: 59, Issue:15

    Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Disease Progressio

1999
Relation of skin polyamines to the hairless phenotype in transgenic mice overexpressing spermidine/spermine N-acetyltransferase.
    The Journal of investigative dermatology, 2001, Volume: 116, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Aging; Alopecia; Animals; Animals, Newborn; Ca

2001
Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.
    Carcinogenesis, 2002, Volume: 23, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Acetyltransferases; Animals; Animals, Genetically Modified; Carcin

2002
Effect of dietary arginine restriction upon ornithine and polyamine metabolism during two-stage epidermal carcinogenesis in the mouse.
    Cancer research, 1991, Jun-01, Volume: 51, Issue:11

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Arginine; DNA; Female; Mice; Ornithine; Ornithine Decarbo

1991