Page last updated: 2024-10-20

putrescine and Cancer of Pancreas

putrescine has been researched along with Cancer of Pancreas in 9 studies

Research Excerpts

ExcerptRelevanceReference
" On the basis of these prior findings, we investigated the effects of alpha-difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase, alone and in combination with cis-diamminedichloroplatinum(II) (cisplatin), to which two of the four cell lines display relative resistance."1.27Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II). ( Black, O; Chang, BK; Gutman, R, 1984)
"CsA had inhibitory effects on H2T pancreatic cancer growth similar to those of alpha-DFMO; these effects were blocked by the addition of the polyamine putrescine."1.27Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro. ( Barranco, SC; James, E; Saydjari, R; Thompson, JC; Townsend, CM, 1986)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19902 (22.22)18.7374
1990's6 (66.67)18.2507
2000's1 (11.11)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chang, BK2
Black, O1
Gutman, R1
Sjöholm, A3
Arkhammar, P1
Welsh, N2
Bokvist, K1
Rorsman, P1
Hallberg, A1
Nilsson, T1
Welsh, M1
Berggren, PO1
Honkanen, RE1
Hoftiezer, V1
Bankston, PW1
Hellerström, C1
Nicolet, T1
Scemama, JL2
Pradayrol, L2
Berthélémy, P1
Seva, C2
Vaysse, N2
Löser, C1
Fölsch, UR1
Paprotny, C1
Creutzfeldt, W1
Nicolet, TG1
Saydjari, R1
Townsend, CM1
Barranco, SC1
James, E1
Thompson, JC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TArgeting Type 1 Diabetes Using POLyamines (TADPOL): A Randomized, Double-Masked, Placebo-Controlled Phase 2 Study to Evaluate the Efficacy and Safety of Difluoromethylornithine (DFMO) to Preserve Insulin Production in Type 1 Diabetes[NCT05594563]Phase 270 participants (Anticipated)Interventional2023-03-14Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

9 other studies available for putrescine and Cancer of Pancreas

ArticleYear
Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II).
    Cancer research, 1984, Volume: 44, Issue:11

    Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Cisplatin; Cricetinae; Drug

1984
Enhanced stimulus-secretion coupling in polyamine-depleted rat insulinoma cells. An effect involving increased cytoplasmic Ca2+, inositol phosphate generation, and phorbol ester sensitivity.
    The Journal of clinical investigation, 1993, Volume: 92, Issue:4

    Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Carbachol; Cytoplasm; Diazoxide; DNA, Ne

1993
Polyamines regulate serine/threonine protein phosphatases in insulin-secreting cells.
    Pancreas, 2000, Volume: 20, Issue:1

    Topics: Arginine; Eflornithine; Enzyme Activation; Enzyme Inhibitors; Histones; Humans; Insulin; Insulin Sec

2000
Inhibitory effects of a calcium antagonist on ornithine decarboxylase induction in pancreatic cancer cell lines.
    Pancreas, 1991, Volume: 6, Issue:6

    Topics: Animals; Calcium; Eflornithine; Enzyme Induction; Ornithine Decarboxylase; Ornithine Decarboxylase I

1991
Increased glucose oxidation and contents of insulin and ATP in polyamine-depleted rat insulinoma cells (RINm5F).
    The Biochemical journal, 1991, Jul-15, Volume: 277 ( Pt 2)

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Line; Cytoplasmic Granules; Eflornithin

1991
Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.
    International journal of cancer, 1991, Oct-21, Volume: 49, Issue:4

    Topics: Animals; Biological Transport; Cell Division; Cell Line; Cells, Cultured; Dexamethasone; Eflornithin

1991
Polyamine concentrations in pancreatic tissue, serum, and urine of patients with pancreatic cancer.
    Pancreas, 1990, Volume: 5, Issue:2

    Topics: Antigens, Tumor-Associated, Carbohydrate; Biogenic Polyamines; Cadaverine; Carcinoembryonic Antigen;

1990
Characterization of putrescine- and spermidine-transport systems of a rat pancreatic acinar tumoral cell line (AR4-2J).
    The Biochemical journal, 1990, Aug-01, Volume: 269, Issue:3

    Topics: Amino Acids; Animals; Biological Transport; Intracellular Fluid; Kinetics; Pancreatic Neoplasms; Put

1990
Effects of cyclosporin A and alpha-difluoromethylornithine on the growth of hamster pancreatic cancer in vitro.
    Journal of the National Cancer Institute, 1986, Volume: 77, Issue:5

    Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cell Cycle; Cell Line; Cell Survival; Cricetinae;

1986