putrescine has been researched along with Brain Ischemia in 13 studies
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The effects of addition of putrescine on IR will be evaluated in terms of inflammation and oxidant-antioxidant balance in liver." | 8.31 | Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion. ( Baltaci, AK; Cetin, N; Dasdelen, D; Menevse, E; Mogulkoc, R, 2023) |
| "The possible effects of the polyamine interconversion pathway on tissue polyamine levels, brain edema formation, and ischemic injury volume were studied by using a selective irreversible inhibitor, MDL 72527, of the interconversion pathway enzyme, polyamine oxidase." | 7.70 | Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Hatcher, J; Rao, AM; Rao, VL, 1999) |
| "Putrescine was extracted from the isolated fractions and measured quantitatively using HPLC and a fluorescence detector." | 5.28 | Putrescine content and structural defects in isolated fractions of rat brain after reversible cerebral ischemia. ( Hossmann, KA; Kocher, M; Oschlies, U; Paschen, W; Röhn, G, 1990) |
| " Addition of carnosine to the treatment protocol for chronic brain ischemia normalized the content of putrescine and spermine." | 5.16 | Effects of carnosine on polyamine levels in red blood cells of patients with hypertonic discirculatory encephalopathy. ( Boldyrev, AA; Fedorova, TN; Makletsova, MG; Maksimova, MY, 2012) |
| " The effects of addition of putrescine on IR will be evaluated in terms of inflammation and oxidant-antioxidant balance in liver." | 4.31 | Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion. ( Baltaci, AK; Cetin, N; Dasdelen, D; Menevse, E; Mogulkoc, R, 2023) |
| "The possible effects of the polyamine interconversion pathway on tissue polyamine levels, brain edema formation, and ischemic injury volume were studied by using a selective irreversible inhibitor, MDL 72527, of the interconversion pathway enzyme, polyamine oxidase." | 3.70 | Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Hatcher, J; Rao, AM; Rao, VL, 1999) |
| "Cerebral ischemia causes activation of ornithine decarboxylase (ODC) gene and subsequent accumulation of putrescine, which might either directly or indirectly affect the outcome of cerebral infarct." | 3.69 | Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion. ( Alhonen, LI; Gröhn, OH; Jänne, J; Järvinen, A; Kauppinen, RA; Lukkarinen, J; Sinervirta, R, 1997) |
| "Putrescine, spermidine, and spermine levels were measured in the cortex, caudoputamen, and hippocampus of rats during 30 min of severe forebrain ischemia (induced by occlusion of both carotid and vertebral arteries) and subsequent recirculation." | 3.67 | Polyamine changes in reversible cerebral ischemia. ( Djuricic, B; Hossmann, KA; Linn, F; Meese, C; Paschen, W; Schmidt-Kastner, R, 1987) |
| "Putrescine efflux was significantly increased in 2/5 animals with MCA occlusion but the increase in release was similar to the spontaneous fluctuations observed in control animals." | 1.29 | Release of spermidine from the rat cortex following permanent middle cerebral artery occlusion. ( Carboni, S; Carter, C; Fage, D; Poignet, H; Scatton, B; Voltz, C, 1995) |
| "We have shown that transient cerebral ischemia gives rise to increased ODC mRNA and enzyme activity in the gerbil brain." | 1.29 | Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage. ( Dempsey, RJ; Hu, Y; Kindy, MS, 1994) |
| "Putrescine was extracted from the isolated fractions and measured quantitatively using HPLC and a fluorescence detector." | 1.28 | Putrescine content and structural defects in isolated fractions of rat brain after reversible cerebral ischemia. ( Hossmann, KA; Kocher, M; Oschlies, U; Paschen, W; Röhn, G, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Dasdelen, D | 1 |
| Cetin, N | 1 |
| Menevse, E | 1 |
| Baltaci, AK | 1 |
| Mogulkoc, R | 1 |
| Makletsova, MG | 1 |
| Fedorova, TN | 1 |
| Maksimova, MY | 1 |
| Boldyrev, AA | 1 |
| Carter, C | 1 |
| Poignet, H | 1 |
| Carboni, S | 1 |
| Fage, D | 1 |
| Voltz, C | 1 |
| Scatton, B | 1 |
| Kindy, MS | 1 |
| Hu, Y | 1 |
| Dempsey, RJ | 2 |
| Lukkarainen, J | 1 |
| Kauppinen, RA | 2 |
| Koistinaho, J | 1 |
| Alhonen, LM | 1 |
| Jänne, J | 2 |
| Lukkarinen, J | 1 |
| Gröhn, OH | 1 |
| Sinervirta, R | 1 |
| Järvinen, A | 1 |
| Alhonen, LI | 1 |
| Wengenack, TM | 1 |
| Curran, GL | 1 |
| Olson, EE | 1 |
| Poduslo, JF | 1 |
| Doğan, A | 1 |
| Rao, AM | 1 |
| Hatcher, J | 1 |
| Rao, VL | 1 |
| Başkaya, MK | 1 |
| Sauer, D | 1 |
| Martin, P | 1 |
| Allegrini, PR | 1 |
| Bernasconi, R | 1 |
| Amacker, H | 1 |
| Fagg, GE | 1 |
| Ferchmin, PA | 1 |
| Koenig, H | 1 |
| Goldstone, AD | 1 |
| Lu, CY | 1 |
| Trout, JJ | 1 |
| Röhn, G | 1 |
| Kocher, M | 1 |
| Oschlies, U | 1 |
| Hossmann, KA | 2 |
| Paschen, W | 2 |
| Schmidt-Kastner, R | 1 |
| Djuricic, B | 1 |
| Meese, C | 1 |
| Linn, F | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for putrescine and Brain Ischemia
| Article | Year |
|---|---|
Effects of carnosine on polyamine levels in red blood cells of patients with hypertonic discirculatory encephalopathy.
Topics: Adult; Aged; Brain Ischemia; Carnosine; Cerebrovascular Disorders; Erythrocytes; Female; Humans; Mal | 2012 |
12 other studies available for putrescine and Brain Ischemia
| Article | Year |
|---|---|
Effects of putrescine on oxidative stress, spermidine/spermine-N(1)-acetyltransferase, inflammation and energy levels in liver and serum in rats with brain ischemia-reperfusion.
Topics: Acetyltransferases; Animals; Brain Ischemia; Inflammation; Liver; Male; Oxidative Stress; Putrescine | 2023 |
Release of spermidine from the rat cortex following permanent middle cerebral artery occlusion.
Topics: Animals; Brain Ischemia; Cerebral Arteries; Cerebral Cortex; Chromatography, High Pressure Liquid; E | 1995 |
Blockade of ornithine decarboxylase enzyme protects against ischemic brain damage.
Topics: Animals; Brain Damage, Chronic; Brain Ischemia; Cell Survival; Eflornithine; Gerbillinae; Male; Neur | 1994 |
Cerebral energy metabolism and immediate early gene induction following severe incomplete ischaemia in transgenic mice overexpressing the human ornithine decarboxylase gene: evidence that putrescine is not neurotoxic in vivo.
Topics: Animals; Biogenic Polyamines; Brain Chemistry; Brain Ischemia; Energy Metabolism; Gene Expression; G | 1995 |
Transgenic rats as models for studying the role of ornithine decarboxylase expression in permanent middle cerebral artery occlusion.
Topics: Animals; Animals, Genetically Modified; Arterial Occlusive Diseases; Brain Ischemia; Cell Death; Dis | 1997 |
Putrescine-modified catalase with preserved enzymatic activity exhibits increased permeability at the blood-nerve and blood-brain barriers.
Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Catalase; Hydrogen-Ion Concentration; Male; Neuroprote | 1997 |
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Blood Gas Analysis; Blood Pressure; Body Temperature; Brain; B | 1999 |
Differing effects of alpha-difluoromethylornithine and CGP 40116 on polyamine levels and infarct volume in a rat model of focal cerebral ischaemia.
Topics: 2-Amino-5-phosphonovalerate; Animals; Brain; Brain Ischemia; Cerebral Infarction; Eflornithine; Magn | 1992 |
Are polyamines modulators of the CNS?
Topics: Animals; Brain Ischemia; Central Nervous System; Neurons; Neurotransmitter Agents; Ornithine Decarbo | 1991 |
Brain polyamines are controlled by N-methyl-D-aspartate receptors during ischemia and recirculation.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Dizocilpine Maleate; Female; Gerbillina | 1990 |
Putrescine content and structural defects in isolated fractions of rat brain after reversible cerebral ischemia.
Topics: Animals; Brain; Brain Ischemia; In Vitro Techniques; Male; Microscopy, Electron; Mitochondria; Myeli | 1990 |
Polyamine changes in reversible cerebral ischemia.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Hippocampus; Polyamines; Putamen; Putrescine; Rats; Spermi | 1987 |