Page last updated: 2024-10-20

putrescine and Brain Edema

putrescine has been researched along with Brain Edema in 5 studies

Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)

Research Excerpts

ExcerptRelevanceReference
"The possible effects of the polyamine interconversion pathway on tissue polyamine levels, brain edema formation, and ischemic injury volume were studied by using a selective irreversible inhibitor, MDL 72527, of the interconversion pathway enzyme, polyamine oxidase."7.70Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Hatcher, J; Rao, AM; Rao, VL, 1999)
" Treatment with glycerol, a reducer of brain edema, lowered the concentration of PUT only in CB, MB and MO."3.72Putrescine as a marker of the effects of 2-chloropropionic acid in the rat brain. ( Camón, L; de Vera, N; Martínez, E, 2004)
"The possible effects of the polyamine interconversion pathway on tissue polyamine levels, brain edema formation, and ischemic injury volume were studied by using a selective irreversible inhibitor, MDL 72527, of the interconversion pathway enzyme, polyamine oxidase."3.70Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Hatcher, J; Rao, AM; Rao, VL, 1999)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
de Vera, N1
Camón, L1
Martínez, E1
Koenig, H1
Goldstone, AD1
Lu, CY1
Fike, JR2
Gobbel, GT2
Marton, LJ2
Seilhan, TM2
Doğan, A1
Rao, AM1
Hatcher, J1
Rao, VL1
Başkaya, MK1
Dempsey, RJ1
Lamborn, K1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731]Phase 260 participants (Actual)Interventional2010-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

5 other studies available for putrescine and Brain Edema

ArticleYear
Putrescine as a marker of the effects of 2-chloropropionic acid in the rat brain.
    Neuroscience letters, 2004, May-27, Volume: 362, Issue:3

    Topics: Analysis of Variance; Animals; Biomarkers; Brain; Brain Edema; Chromatography, High Pressure Liquid;

2004
Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines.
    Biochemical and biophysical research communications, 1983, Nov-15, Volume: 116, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Cerebrovascular Circulation; Eflornithin

1983
Radiation brain injury is reduced by the polyamine inhibitor alpha-difluoromethylornithine.
    Radiation research, 1994, Volume: 138, Issue:1

    Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain; Brain Edema; Capillary Permeability; Cere

1994
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion.
    Journal of neurochemistry, 1999, Volume: 72, Issue:2

    Topics: Animals; Arterial Occlusive Diseases; Blood Gas Analysis; Blood Pressure; Body Temperature; Brain; B

1999
Modification of radiation-induced brain injury by alpha-difluoromethylornithine.
    Radiation research, 1991, Volume: 128, Issue:3

    Topics: Animals; Blood-Brain Barrier; Brachytherapy; Brain; Brain Edema; Dogs; Eflornithine; Female; Infusio

1991