putrescine has been researched along with Brain Edema in 5 studies
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Excerpt | Relevance | Reference |
---|---|---|
"The possible effects of the polyamine interconversion pathway on tissue polyamine levels, brain edema formation, and ischemic injury volume were studied by using a selective irreversible inhibitor, MDL 72527, of the interconversion pathway enzyme, polyamine oxidase." | 7.70 | Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Hatcher, J; Rao, AM; Rao, VL, 1999) |
" Treatment with glycerol, a reducer of brain edema, lowered the concentration of PUT only in CB, MB and MO." | 3.72 | Putrescine as a marker of the effects of 2-chloropropionic acid in the rat brain. ( Camón, L; de Vera, N; Martínez, E, 2004) |
"The possible effects of the polyamine interconversion pathway on tissue polyamine levels, brain edema formation, and ischemic injury volume were studied by using a selective irreversible inhibitor, MDL 72527, of the interconversion pathway enzyme, polyamine oxidase." | 3.70 | Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion. ( Başkaya, MK; Dempsey, RJ; Doğan, A; Hatcher, J; Rao, AM; Rao, VL, 1999) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (20.00) | 18.7374 |
1990's | 3 (60.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
de Vera, N | 1 |
Camón, L | 1 |
Martínez, E | 1 |
Koenig, H | 1 |
Goldstone, AD | 1 |
Lu, CY | 1 |
Fike, JR | 2 |
Gobbel, GT | 2 |
Marton, LJ | 2 |
Seilhan, TM | 2 |
Doğan, A | 1 |
Rao, AM | 1 |
Hatcher, J | 1 |
Rao, VL | 1 |
Başkaya, MK | 1 |
Dempsey, RJ | 1 |
Lamborn, K | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Phase II Study of the Effects of Tiopronin on 3-Aminopropanal Level & Neurologic Outcome After Aneurysmal Subarachnoid Hemorrhage[NCT01095731] | Phase 2 | 60 participants (Actual) | Interventional | 2010-04-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
5 other studies available for putrescine and Brain Edema
Article | Year |
---|---|
Putrescine as a marker of the effects of 2-chloropropionic acid in the rat brain.
Topics: Analysis of Variance; Animals; Biomarkers; Brain; Brain Edema; Chromatography, High Pressure Liquid; | 2004 |
Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Cerebrovascular Circulation; Eflornithin | 1983 |
Radiation brain injury is reduced by the polyamine inhibitor alpha-difluoromethylornithine.
Topics: Analysis of Variance; Animals; Blood-Brain Barrier; Brain; Brain Edema; Capillary Permeability; Cere | 1994 |
Effects of MDL 72527, a specific inhibitor of polyamine oxidase, on brain edema, ischemic injury volume, and tissue polyamine levels in rats after temporary middle cerebral artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Blood Gas Analysis; Blood Pressure; Body Temperature; Brain; B | 1999 |
Modification of radiation-induced brain injury by alpha-difluoromethylornithine.
Topics: Animals; Blood-Brain Barrier; Brachytherapy; Brain; Brain Edema; Dogs; Eflornithine; Female; Infusio | 1991 |