pustulan and Lung-Neoplasms

pustulan has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for pustulan and Lung-Neoplasms

Article	Year
Studies on antitumor effect of corynebacterium parvum and pustulan on Lewis lung carcinoma in mice. Archivum immunologiae et therapiae experimentalis, 1982, Volume: 30, Issue:5-6 Antitumor effect of two biological adjuvants and their supported mechanism was studied in mice inoculated s.c. with Lewis lung carcinoma (LL) cells. The studies included in vivo tests: median survival time (MST) evaluation, tumor weight inhibition (TWI) and splenohepatomegaly measurements. The nonspecific in vitro cytostatic effect of peritoneal adherent cells stimulated with adjuvants was measured by inhibition of 3H thymidine incorporation into tumor cells. In in vivo studies the reproducible 20-30% of TWI was achieved in groups treated with both drugs, while no significant increase in MST was observed. Corynebacterium parvum activated peritoneal adherent cells caused 80% DNA synthesis inhibition of tumor cells while Pustulan activated peritoneal cells showed very low (26%) cytostatic effect. Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Bacterial Vaccines; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Organ Size; Polysaccharides; Propionibacterium acnes; Spleen; Time Factors	1982

Article

Year

Studies on antitumor effect of corynebacterium parvum and pustulan on Lewis lung carcinoma in mice.

Archivum immunologiae et therapiae experimentalis, 1982, Volume: 30, Issue:5-6

Antitumor effect of two biological adjuvants and their supported mechanism was studied in mice inoculated s.c. with Lewis lung carcinoma (LL) cells. The studies included in vivo tests: median survival time (MST) evaluation, tumor weight inhibition (TWI) and splenohepatomegaly measurements. The nonspecific in vitro cytostatic effect of peritoneal adherent cells stimulated with adjuvants was measured by inhibition of 3H thymidine incorporation into tumor cells. In in vivo studies the reproducible 20-30% of TWI was achieved in groups treated with both drugs, while no significant increase in MST was observed. Corynebacterium parvum activated peritoneal adherent cells caused 80% DNA synthesis inhibition of tumor cells while Pustulan activated peritoneal cells showed very low (26%) cytostatic effect.

Topics: Adjuvants, Immunologic; Animals; Antineoplastic Agents; Bacterial Vaccines; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Organ Size; Polysaccharides; Propionibacterium acnes; Spleen; Time Factors

1982