purine has been researched along with Trypanosomiasis, African in 3 studies
1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.
Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Drug resistance and toxic side effects of old drugs call for novel and unorthodox strategies for new and safe treatment options." | 1.42 | Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy. ( Alkhaldi, AA; Barnes, RL; Brun, R; de Koning, HP; Ebiloma, GU; Kaiser, M; Koomen, GJ; McCulloch, R; Rodenko, B; Wanner, MJ, 2015) |
| " A lead inhibitor that had potent activity against the trypanosomal protease TbcatB in vitro and cultured parasites ex vivo was optimized by rationally driven medicinal chemistry to an inhibitor that is orally available, penetrates the CNS, has a promising pharmacokinetic profile, and is non-toxic at 200mg/kg in a repeat dosage study." | 1.36 | Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. ( Brun, R; Guy, RK; Kaiser, M; Lemoff, A; Lu, M; Mallari, JP; Zhu, F, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rodenko, B | 1 |
| Wanner, MJ | 1 |
| Alkhaldi, AA | 1 |
| Ebiloma, GU | 1 |
| Barnes, RL | 1 |
| Kaiser, M | 2 |
| Brun, R | 2 |
| McCulloch, R | 1 |
| Koomen, GJ | 1 |
| de Koning, HP | 1 |
| Mallari, JP | 1 |
| Zhu, F | 1 |
| Lemoff, A | 1 |
| Lu, M | 1 |
| Guy, RK | 1 |
| Steeves, CH | 1 |
| Bearne, SL | 1 |
3 other studies available for purine and Trypanosomiasis, African
| Article | Year |
|---|---|
Targeting the parasite's DNA with methyltriazenyl purine analogs is a safe, selective, and efficacious antitrypanosomal strategy.
Topics: Animals; Cell Line; DNA, Protozoan; Female; Mice; Purines; Trypanocidal Agents; Trypanosoma brucei b | 2015 |
Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models.
Topics: Administration, Oral; Animals; Cysteine Endopeptidases; Disease Models, Animal; Humans; Mice; Nitril | 2010 |
Activation and inhibition of CTP synthase from Trypanosoma brucei, the causative agent of African sleeping sickness.
Topics: Antiprotozoal Agents; Biocatalysis; Carbon-Nitrogen Ligases; Dose-Response Relationship, Drug; Enzym | 2011 |