purine has been researched along with Rheumatoid Arthritis in 5 studies
1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5-aminoimidazole-4-carboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation." | 9.11 | The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. ( Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA, 2004) |
| "Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been attributed to clinical heterogeneity and genetic variations influencing MTX pharmacology." | 7.75 | Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians. ( Aneja, R; Arya, V; Das, M; Dhir, V; Grover, R; Gupta, R; Juyal, RC; K, TB; Kumar, A; Kumar, U; Marwaha, V; Raghu, P; Shankar, S; Sharma, S; Singh, P, 2009) |
| "To study the possible association of purine enzyme activities with response to azathioprine (AZA) treatment in rheumatoid arthritis (RA) and their correlation with parameters of disease activity." | 7.69 | Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine. A pilot study. ( Boerbooms, AM; De Abreu, RA; de Graaf, R; Kerstens, PJ; Lambooy, LH; Stolk, JN; van de Putte, LB, 1994) |
| "To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5-aminoimidazole-4-carboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation." | 5.11 | The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. ( Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA, 2004) |
| " Methotrexate (MTX), a first-line rheumatoid arthritis (RA) treatment, inhibits mammalian dihydrofolate reductase (DHFR), but whether it directly impacts gut bacteria is unclear." | 4.02 | Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation. ( Alexander, M; Deshpande, I; Nayak, RR; Patterson, AD; Rimal, B; Scher, JU; Stapleton-Gray, K; Turnbaugh, PJ; Ubeda, C, 2021) |
| "Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been attributed to clinical heterogeneity and genetic variations influencing MTX pharmacology." | 3.75 | Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians. ( Aneja, R; Arya, V; Das, M; Dhir, V; Grover, R; Gupta, R; Juyal, RC; K, TB; Kumar, A; Kumar, U; Marwaha, V; Raghu, P; Shankar, S; Sharma, S; Singh, P, 2009) |
| "To study the possible association of purine enzyme activities with response to azathioprine (AZA) treatment in rheumatoid arthritis (RA) and their correlation with parameters of disease activity." | 3.69 | Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine. A pilot study. ( Boerbooms, AM; De Abreu, RA; de Graaf, R; Kerstens, PJ; Lambooy, LH; Stolk, JN; van de Putte, LB, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nayak, RR | 1 |
| Alexander, M | 1 |
| Deshpande, I | 1 |
| Stapleton-Gray, K | 1 |
| Rimal, B | 1 |
| Patterson, AD | 1 |
| Ubeda, C | 1 |
| Scher, JU | 1 |
| Turnbaugh, PJ | 1 |
| Sharma, S | 1 |
| Das, M | 1 |
| Kumar, A | 1 |
| Marwaha, V | 1 |
| Shankar, S | 1 |
| Singh, P | 1 |
| Raghu, P | 1 |
| Aneja, R | 1 |
| Grover, R | 1 |
| Arya, V | 1 |
| Dhir, V | 1 |
| Gupta, R | 1 |
| Kumar, U | 1 |
| Juyal, RC | 1 |
| K, TB | 1 |
| Morgan, SL | 1 |
| Oster, RA | 1 |
| Lee, JY | 1 |
| Alarcón, GS | 1 |
| Baggott, JE | 1 |
| Kondo, H | 1 |
| Iizuka, N | 1 |
| Kerstens, PJ | 1 |
| Stolk, JN | 1 |
| Boerbooms, AM | 1 |
| Lambooy, LH | 1 |
| de Graaf, R | 1 |
| De Abreu, RA | 1 |
| van de Putte, LB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mechanisms of Antifolate Efficacy in Arthritis[NCT00000395] | Phase 2 | 40 participants (Actual) | Interventional | 1996-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for purine and Rheumatoid Arthritis
| Article | Year |
|---|---|
[Mizoribine].
Topics: Animals; Arthritis, Rheumatoid; Depression, Chemical; Guanosine Monophosphate; Humans; Immunosuppres | 2005 |
1 trial available for purine and Rheumatoid Arthritis
| Article | Year |
|---|---|
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homo | 2004 |
3 other studies available for purine and Rheumatoid Arthritis
| Article | Year |
|---|---|
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Bacteria; Female; Gastrointestinal Microbiome; | 2021 |
Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians.
Topics: AMP Deaminase; Arthritis, Rheumatoid; Female; Genetic Variation; Humans; Hydroxymethyl and Formyl Tr | 2009 |
Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine. A pilot study.
Topics: 5'-Nucleotidase; Adenine Phosphoribosyltransferase; Adult; Aged; Arthritis, Rheumatoid; Azathioprine | 1994 |