purine has been researched along with Neoplasms in 111 studies
1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rates of malignancy were within published ranges for transplant recipients." | 2.68 | Mycophenolate mofetil for maintenance therapy in kidney transplantation. ( Gonwa, TA, 1996) |
| "Cell purine metabolism is an important drug target." | 2.61 | Purine auxotrophy: Possible applications beyond genetic marker. ( Kokina, A; Liepins, J; Ozolina, Z, 2019) |
| "Cladribine was synthesized as a purine analogue drug that inhibited adenosine deaminase." | 2.45 | Cladribine: not just another purine analogue? ( Epner, EM; Phillips, JD; Spurgeon, S; Yu, M, 2009) |
| "Analysis of The Cancer Genome Atlas database revealed that all Hsp90 paralogs were upregulated in prostate cancer." | 1.56 | Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1. ( Chae, YC; Hong, JH; Hu, S; Kang, BH; Kim, SY; Lee, JE; Nam, D; Park, HK; Park, JB; Yoon, NG; Yoon, S, 2020) |
| "Cancer cachexia is a systemic wasting syndrome characterized by anorexia and loss of body weight." | 1.51 | A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain. ( Hisaka, A; Kurebayashi, N; Miyano, K; Nonaka, M; Sakurai, T; Sato, H; Uezono, Y; Uzu, M; Yanagihara, K, 2019) |
| " GNMT expression in vivo improves folate retention and bioavailability in the liver." | 1.42 | Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR). ( Chiang, EP; Ko, HA; Lin, YJ; Tang, FY; Wang, YC; Wu, MT, 2015) |
| "We treated A2780 (ovarian cancer) and HCT-116 (colorectal cancer) cell lines with FK866 in the presence and absence of nicotinic acid." | 1.40 | Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells. ( Dong, S; Kuo, MS; Nikolayev, A; Tolstikov, V; Zhao, G, 2014) |
| "We use these tools to demonstrate that cancer cells use individual Hsp90 paralogs to regulate a client protein in a tumor-specific manner and in response to proteome alterations." | 1.39 | Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. ( Chiosis, G; Finotti, P; Gewirth, DT; Patel, HJ; Patel, PD; Que, NS; Seidler, PM; Stephani, RA; Sun, W; Taldone, T; Yan, P; Yang, C, 2013) |
| "Recent observations on cancer cell metabolism indicate increased serine synthesis from glucose as a marker of poor prognosis." | 1.39 | Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells. ( Bertino, JR; Boros, LG; Chan, LL; DiPaola, RS; Dolfi, SC; Dvorzhinski, D; Gounder, M; Hirshfield, KM; Lin, H; Markert, EK; Oltvai, ZN; Qiu, J; Tedeschi, PM; Vazquez, A, 2013) |
| " In the second part, where the interaction between CsA and 2-CdA was examined, the animals were administered CsA at a dose of 15 mg/kg, or 2-CdA at a dose of 20 mg/kg, or CsA combined with 2-CdA at the same doses as in monotherapy." | 1.31 | Cytotoxic effect of cyclosporin A alone and in combination with 2-chlorodeoxyadenosine against P388 murine leukemia in vivo. ( Józefowicz-Okonkwo, G; Robak, T; Szmigielska-Kapłon, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 87 (78.38) | 18.7374 |
| 1990's | 3 (2.70) | 18.2507 |
| 2000's | 6 (5.41) | 29.6817 |
| 2010's | 12 (10.81) | 24.3611 |
| 2020's | 3 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Ghergurovich, JM | 1 |
| Xu, X | 1 |
| Wang, JZ | 1 |
| Yang, L | 1 |
| Ryseck, RP | 1 |
| Wang, L | 2 |
| Rabinowitz, JD | 1 |
| Villa, E | 1 |
| Ben-Sahra, I | 1 |
| Park, HK | 1 |
| Yoon, NG | 1 |
| Lee, JE | 1 |
| Hu, S | 1 |
| Yoon, S | 1 |
| Kim, SY | 1 |
| Hong, JH | 1 |
| Nam, D | 1 |
| Chae, YC | 1 |
| Park, JB | 1 |
| Kang, BH | 1 |
| Uzu, M | 1 |
| Nonaka, M | 1 |
| Miyano, K | 1 |
| Sato, H | 1 |
| Kurebayashi, N | 1 |
| Yanagihara, K | 1 |
| Sakurai, T | 1 |
| Hisaka, A | 1 |
| Uezono, Y | 1 |
| Kokina, A | 1 |
| Ozolina, Z | 1 |
| Liepins, J | 1 |
| Bibian, M | 1 |
| Rahaim, RJ | 1 |
| Choi, JY | 1 |
| Noguchi, Y | 1 |
| Schürer, S | 1 |
| Chen, W | 1 |
| Nakanishi, S | 1 |
| Licht, K | 1 |
| Rosenberg, LH | 1 |
| Li, L | 2 |
| Feng, Y | 1 |
| Cameron, MD | 1 |
| Duckett, DR | 1 |
| Cleveland, JL | 1 |
| Roush, WR | 1 |
| Patel, PD | 1 |
| Yan, P | 1 |
| Seidler, PM | 1 |
| Patel, HJ | 1 |
| Sun, W | 1 |
| Yang, C | 1 |
| Que, NS | 1 |
| Taldone, T | 1 |
| Finotti, P | 1 |
| Stephani, RA | 1 |
| Gewirth, DT | 1 |
| Chiosis, G | 1 |
| Tedeschi, PM | 1 |
| Markert, EK | 1 |
| Gounder, M | 1 |
| Lin, H | 1 |
| Dvorzhinski, D | 1 |
| Dolfi, SC | 1 |
| Chan, LL | 1 |
| Qiu, J | 1 |
| DiPaola, RS | 1 |
| Hirshfield, KM | 1 |
| Boros, LG | 1 |
| Bertino, JR | 1 |
| Oltvai, ZN | 1 |
| Vazquez, A | 1 |
| Ma, L | 1 |
| Ma, Q | 1 |
| Li, X | 1 |
| Cheng, L | 1 |
| Li, K | 1 |
| Li, S | 1 |
| Tolstikov, V | 1 |
| Nikolayev, A | 1 |
| Dong, S | 1 |
| Zhao, G | 1 |
| Kuo, MS | 1 |
| Palkar, MB | 1 |
| Rane, RA | 1 |
| Thapliyal, N | 1 |
| Shaikh, MS | 1 |
| Alwan, WS | 1 |
| Jain, KS | 1 |
| Karunanidhi, S | 1 |
| Patel, HM | 1 |
| Hampannavar, GA | 1 |
| Karpoormath, R | 1 |
| Wang, YC | 1 |
| Wu, MT | 1 |
| Lin, YJ | 1 |
| Tang, FY | 1 |
| Ko, HA | 1 |
| Chiang, EP | 1 |
| Liekens, S | 1 |
| Bronckaers, A | 1 |
| Balzarini, J | 1 |
| Spurgeon, S | 1 |
| Yu, M | 1 |
| Phillips, JD | 1 |
| Epner, EM | 1 |
| Coulthard, SA | 1 |
| Redfern, CP | 1 |
| Vikingsson, S | 1 |
| Lindqvist-Appell, M | 1 |
| Skoglund, K | 1 |
| Jakobsen-Falk, I | 1 |
| Hall, AG | 1 |
| Taylor, GA | 1 |
| Hogarth, LA | 1 |
| Fridley, BL | 1 |
| Batzler, A | 1 |
| Li, F | 1 |
| Matimba, A | 1 |
| Jenkins, GD | 1 |
| Ji, Y | 1 |
| Weinshilboum, RM | 1 |
| Benci, K | 1 |
| Mandić, L | 1 |
| Suhina, T | 1 |
| Sedić, M | 1 |
| Klobučar, M | 1 |
| Kraljević Pavelić, S | 1 |
| Pavelić, K | 1 |
| Wittine, K | 1 |
| Mintas, M | 1 |
| Józefowicz-Okonkwo, G | 1 |
| Szmigielska-Kapłon, A | 1 |
| Robak, T | 1 |
| LEPAGE, GA | 16 |
| CONZELMAN, GM | 1 |
| MANDEL, HG | 1 |
| SMITH, PK | 1 |
| RHOADS, CP | 4 |
| WOODHOUSE, DL | 1 |
| BARCLAY, RK | 1 |
| GARFINKEL, E | 1 |
| BENNETT, LL | 4 |
| SKIPPER, HE | 4 |
| STOCK, CC | 2 |
| YAMAMOTO, S | 1 |
| MIZUNOE, S | 1 |
| MAZIMA, K | 1 |
| NOMURA, T | 1 |
| WERKHEISER, WC | 1 |
| WINZLER, RJ | 1 |
| VISSER, DW | 2 |
| SCHNEIDER, W | 1 |
| EBNER, H | 1 |
| FERNANDES, JF | 1 |
| LINDNER, A | 1 |
| EDMONDS, M | 1 |
| TOOLAN, HW | 1 |
| BURCHENAL, JH | 3 |
| DUBOIS-FERRIERE, H | 1 |
| ZUMSTEIN, P | 1 |
| BOUVIER, C | 1 |
| KALACI, J | 1 |
| SORG, D | 1 |
| VAUTHIER, J | 1 |
| HAUSSER, A | 1 |
| GREIG, HB | 1 |
| METZ, J | 1 |
| LAIRD, MH | 1 |
| ZENTKOWSKY, D | 1 |
| FITZPATRICK, MM | 1 |
| SARTORELLI, AC | 7 |
| BROCKMAN, RW | 4 |
| SPARKS, MC | 1 |
| SIMPSON, MS | 1 |
| PREZIOSI, P | 1 |
| WILLIAMS, AM | 3 |
| HARRINGTON, H | 1 |
| HENDERSON, JF | 4 |
| STEIN, AM | 1 |
| MURAKAMI, WT | 1 |
| LEDOUX, L | 1 |
| PILERI, A | 1 |
| POZNANSKALINDE, H | 1 |
| VANDERHAEGHE, F | 1 |
| JUNGA, IG | 3 |
| AKERS, JR | 1 |
| BOOTH, BA | 4 |
| KRAKOFF, IH | 1 |
| BALIS, ME | 2 |
| MAGILL, JW | 1 |
| NARY, D | 1 |
| WHEELER, GP | 4 |
| ALEXANDER, JA | 3 |
| SIMPSON, L | 1 |
| WILCOX, WS | 1 |
| BERGQUIST, PL | 2 |
| MATTHEWS, RE | 2 |
| LANGER, L | 1 |
| KLENOW, H | 1 |
| RUNDLES, RW | 2 |
| FULMER, TE | 1 |
| DOYLE, RT | 1 |
| GORE, TW | 1 |
| SCOTT, JF | 1 |
| TAFT, EB | 1 |
| LETOURNEAU, NW | 1 |
| LEUBNER, H | 1 |
| POMALES, R | 2 |
| BIEBER, S | 1 |
| FRIEDMAN, R | 1 |
| HITCHINGS, GH | 3 |
| ANDERSON, EP | 2 |
| REGELSON, W | 1 |
| HOLLAND, JF | 1 |
| FREI, E | 1 |
| GOLD, GL | 1 |
| HALL, T | 1 |
| KRANT, M | 1 |
| MILLER, SO | 1 |
| HUTCHISON, DJ | 1 |
| UJHAZY, V | 1 |
| HEINEMANN, B | 1 |
| HOWARD, AJ | 1 |
| OTA, K | 1 |
| NAGANO, H | 1 |
| INOUE, S | 1 |
| SAGGIOMO, AJ | 1 |
| NODIFF, EA | 1 |
| POTTER, VR | 1 |
| BRAGONIER, JR | 1 |
| ROESKY, N | 1 |
| CARVER, MJ | 1 |
| FRANZ, HE | 1 |
| FRANZ, M | 1 |
| DECKER, K | 1 |
| CAPPUCCINO, JG | 1 |
| GEORGE, M | 1 |
| MERKER, PC | 1 |
| TARNOWSKI, GS | 1 |
| ITZHAKI, S | 1 |
| SINAI, Y | 1 |
| LACHMAN, C | 1 |
| COHEN, S | 1 |
| BRINK, JJ | 1 |
| O'BRIEN, DE | 1 |
| WESTOVER, JD | 1 |
| ROBINS, RK | 1 |
| CHENG, CC | 1 |
| POPOVIC, I | 1 |
| STEFANOVIC, O | 1 |
| POPOVIC, D | 1 |
| ELION, GB | 2 |
| CLARKE, DA | 1 |
| PHILIPS, FS | 1 |
| STERNBERG, SS | 1 |
| ELLISON, RR | 1 |
| MURPHY, ML | 1 |
| KARNOFSKY, DA | 2 |
| SYKES, MP | 1 |
| TAN, TC | 1 |
| MERMANN, AC | 1 |
| YUCEOGLU, M | 1 |
| MYERS, WP | 2 |
| KRAKOFF, I | 1 |
| ALBERSTADT, N | 1 |
| HALL, BE | 1 |
| RICHARDS, MD | 1 |
| WILLETT, FM | 1 |
| FEICHTMEIR, TV | 1 |
| FARBER, S | 1 |
| CRAGO, JA | 1 |
| FOUNTAIN, JR | 1 |
| BETHELL, FH | 1 |
| THOMPSON, DS | 1 |
| HYMAN, GA | 1 |
| GELLHORN, A | 1 |
| WOLFF, JA | 1 |
| ROSENTHAL, N | 1 |
| ROSENTHAL, RL | 1 |
| LEE, SL | 1 |
| GAFFNEY, PC | 1 |
| COOPER, WM | 1 |
| ZAHL, PA | 1 |
| ALBAUM, HG | 1 |
| GREENLEES, JL | 1 |
| KIT, S | 1 |
| BIESELE, JJ | 1 |
| BERGER, RE | 1 |
| WILSON, AY | 1 |
| KINGSLEY-PILLERS, EM | 1 |
| SOUTHAM, CM | 1 |
| ESCHER, GC | 1 |
| CRAVER, LF | 1 |
| DARGEON, HW | 1 |
| TYNER, EP | 1 |
| HEIDELBERGER, C | 1 |
| LOMBARDO, ME | 1 |
| TRAVERS, JJ | 1 |
| CERECEDO, LR | 1 |
| Schultz, RM | 1 |
| Dalgarno, D | 1 |
| Stehle, T | 1 |
| Narula, S | 1 |
| Schelling, P | 1 |
| van Schravendijk, MR | 1 |
| Adams, S | 1 |
| Andrade, L | 1 |
| Keats, J | 1 |
| Ram, M | 1 |
| Jin, L | 1 |
| Grossman, T | 1 |
| MacNeil, I | 1 |
| Metcalf, C | 1 |
| Shakespeare, W | 1 |
| Wang, Y | 1 |
| Keenan, T | 1 |
| Sundaramoorthi, R | 1 |
| Bohacek, R | 1 |
| Weigele, M | 1 |
| Sawyer, T | 1 |
| Xu, L | 1 |
| Chong, Y | 1 |
| Hwang, I | 1 |
| D'Onofrio, A | 1 |
| Amore, K | 1 |
| Beardsley, GP | 1 |
| Li, C | 1 |
| Olson, AJ | 1 |
| Boger, DL | 1 |
| Wilson, IA | 1 |
| Gonwa, TA | 1 |
| Sommer, SS | 1 |
| Ketterling, RP | 1 |
| Nakamura, T | 1 |
| Ueda, T | 1 |
| Uchida, M | 1 |
11 reviews available for purine and Neoplasms
| Article | Year |
|---|---|
Purine auxotrophy: Possible applications beyond genetic marker.
Topics: Adenine; Cell Cycle Checkpoints; Drug Development; Eukaryota; Humans; Neoplasms; Purines; Saccharomy | 2019 |
An insight into purine, tyrosine and tryptophan derived marine antineoplastic alkaloids.
Topics: Alkaloids; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Aquatic Organisms; Humans; Neopl | 2015 |
Cladribine: not just another purine analogue?
Topics: Adenosine Deaminase Inhibitors; Antineoplastic Agents; Autoimmune Diseases; Cladribine; Clinical Tri | 2009 |
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tum | 1963 |
MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS.
Topics: Alkylating Agents; Antineoplastic Agents; Azaserine; Dactinomycin; DNA; Drug Resistance; Drug Resist | 1963 |
CROSS RESISTANCE AND COLLATERAL SENSITIVITY STUDIES IN CANCER CHEMOTHERAPY.
Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Azaserine; Colchicine; Drug Resistance; D | 1963 |
[PROBLEMS IN ACQUIRED RESISTANCE OF TUMORS TOWARDS CYTOSTATICS].
Topics: Alkylating Agents; Antimetabolites; Antineoplastic Agents; Cytostatic Agents; Folic Acid Antagonists | 1964 |
DETERMINATION OF ALTERATIONS IN METABOLISM OF PURINES.
Topics: Metabolism; Neoplasms; Purines | 1964 |
Preclinical development of Alimta (Pemetrexed, LY231514), a multitargeted antifolate.
Topics: Animals; Antineoplastic Agents; Biological Transport; Drug Resistance, Neoplasm; Folic Acid Antagoni | 2005 |
The factor IX gene as a model for analysis of human germline mutations: an update.
Topics: Age Factors; Base Sequence; Factor IX; Founder Effect; Germ-Line Mutation; Hemophilia B; Humans; Mol | 1996 |
[Clinical pharmacology of anticancer agents [Part 5] Antimetabolites (2)].
Topics: Antimetabolites, Antineoplastic; Folic Acid Antagonists; Guanine Nucleotides; Humans; Methotrexate; | 1992 |
1 trial available for purine and Neoplasms
| Article | Year |
|---|---|
Mycophenolate mofetil for maintenance therapy in kidney transplantation.
Topics: Antilymphocyte Serum; Azathioprine; Cytomegalovirus Infections; Diarrhea; Double-Blind Method; Graft | 1996 |
99 other studies available for purine and Neoplasms
| Article | Year |
|---|---|
Methionine synthase supports tumour tetrahydrofolate pools.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Cell Line, Tumor; Cell Proliferation; Fol | 2021 |
ASS1igning purine dependency to cancer.
Topics: Humans; Neoplasms; Purines | 2020 |
Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; HeLa Cells; Hep G2 Cells; HSP90 Heat-Shock Protein | 2020 |
A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain.
Topics: Administration, Oral; Animals; Brain; Cachexia; Disease Models, Animal; Febuxostat; Male; Mice, Inbr | 2019 |
Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties.
Topics: Animals; Antineoplastic Agents; Binding Sites; Casein Kinase 1 epsilon; Casein Kinase Idelta; Cataly | 2013 |
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Topics: HSP90 Heat-Shock Proteins; Humans; Neoplasms; Purines; Receptor, ErbB-2; Structure-Activity Relation | 2013 |
Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells.
Topics: Adenosine Triphosphate; Amino Acid Oxidoreductases; Animals; Carrier Proteins; Cell Line, Tumor; Emb | 2013 |
Transcriptomic analysis of differentially expressed genes in the Ras1(CA)-overexpressed and wildtype posterior silk glands.
Topics: Animals; Animals, Genetically Modified; Bombyx; Cell Cycle; Computational Biology; Gene Expression P | 2014 |
Metabolomics analysis of metabolic effects of nicotinamide phosphoribosyltransferase (NAMPT) inhibition on human cancer cells.
Topics: Amino Acids; Cell Line, Tumor; Citric Acid Cycle; Cluster Analysis; Creatine; Glycolysis; Humans; Li | 2014 |
Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR).
Topics: Animals; Carbon; DNA Damage; DNA Methylation; Folic Acid; Genotype; Glycine N-Methyltransferase; Hep | 2015 |
Improvement of purine and pyrimidine antimetabolite-based anticancer treatment by selective suppression of mycoplasma-encoded catabolic enzymes.
Topics: Antimetabolites, Antineoplastic; Drug Therapy; Humans; Models, Biological; Molecular Sequence Data; | 2009 |
Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers.
Topics: Antimetabolites, Antineoplastic; Cell Line, Tumor; Drug Resistance, Neoplasm; Gene Deletion; Humans; | 2011 |
Gene set analysis of purine and pyrimidine antimetabolites cancer therapies.
Topics: Antimetabolites; Antineoplastic Agents; Area Under Curve; Cell Line, Tumor; Deoxycytidine; Gemcitabi | 2011 |
Novel coumarin derivatives containing 1,2,4-triazole, 4,5-dicyanoimidazole and purine moieties: synthesis and evaluation of their cytostatic activity.
Topics: Antineoplastic Agents; Cell Line, Tumor; Coumarins; Drug Screening Assays, Antitumor; HeLa Cells; He | 2012 |
Cytotoxic effect of cyclosporin A alone and in combination with 2-chlorodeoxyadenosine against P388 murine leukemia in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclosporine; Drug Synergism; I | 2002 |
In vitro incorporation of glycine-2-C14 into purines and proteins.
Topics: Glycine; In Vitro Techniques; Neoplasms; Nucleic Acids; Proteins; Purines | 1953 |
The incorporation of radiocarbon from 4-amino-5-imidazolecarboxamide into the purines of tumor-bearing mice.
Topics: Aminoimidazole Carboxamide; Animals; Imidazoles; Mice; Neoplasms; Purines | 1953 |
Rational cancer chemotherapy.
Topics: Neoplasms; Purines | 1954 |
The purine and pyrimidine composition of some deoxyribonucleic acids from tumours.
Topics: DNA; Neoplasms; Nucleic Acids; Purines; Pyrimidines | 1954 |
Glycine and adenine as precursors of nucleic acid purines in tumor-bearing mice.
Topics: Adenine; Animals; Glycine; Mice; Neoplasms; Nucleic Acids; Purines | 1955 |
Searches for exploitable biochemical differences between normal and cancer cells. I. Nucleic acid purine metabolism in animal neoplasms.
Topics: Animals; Metabolic Networks and Pathways; Neoplasms; Nucleic Acids; Purines | 1955 |
[Effect of 6-mercaptopurine on inplanted malignant tumor of animal].
Topics: Animals; Mercaptopurine; Neoplasms; Neoplasms, Experimental; Purines | 1955 |
Metabolic inhibitors and nucleotide turnover. I. Inhibition of uptake of radiophosphate in rat liver and hepatoma slices.
Topics: Animals; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; Neoplasms; Nucleic Acids; Nucleotides; P | 1955 |
[Purine and pyrimidine bases of desoxyribonucleic acids in Ehrlich ascites carcinoma in mouse].
Topics: Animals; Ascites; DNA; Kidney; Liver; Mice; Neoplasms; Nucleic Acids; Purines; Pyrimidines | 1955 |
The influence of azaserine and 6-mercaptopurine on the in vivo metabolism of ascites tumor cells.
Topics: Animals; Anti-Bacterial Agents; Ascites; Azaserine; Carcinoma, Ehrlich Tumor; Mercaptopurine; Neopla | 1956 |
Purine metabolism in Ehrlich carcinoma cells.
Topics: Humans; Metabolic Networks and Pathways; Neoplasms; Purines | 1956 |
Searches for exploitable biochemical differences between normal and cancer cells. II. Nucleic acid purine metabolism in human tumors.
Topics: Intestinal Mucosa; Liver; Metabolic Networks and Pathways; Neoplasms; Nucleic Acids; Purines | 1956 |
Clinical effects of purines.
Topics: Humans; Neoplasms; Purines | 1956 |
[Cortisone in massive doses and 6-mercaptopurine in the treatment of acute leucemias in adult; possibility of producing successive remissions].
Topics: Cortisone; Leukemia; Mercaptopurine; Neoplasms; Purines | 1956 |
Chemotherapy of leukaemia. II. 6-Mercaptopurine (purinethol) in the treatment of acute leukaemia and some other neoplastic diseases of the reticuloendothelial system.
Topics: Leukemia; Mercaptopurine; Mononuclear Phagocyte System; Neoplasms; Purines | 1956 |
Purine synthesis in ascites tumor cells.
Topics: Animals; Ascites; Biochemical Phenomena; Carcinoma, Ehrlich Tumor; Neoplasms; Purines | 1957 |
Purine deoxyribonucleotides in rat tumor.
Topics: Animals; Deoxyribonucleotides; Neoplasms; Nucleotides; Purines; Rats | 1957 |
Searches for exploitable biochemical differences between normal and cancer cells. III. Effects of aminoimidazolecarboxamide on purine metabolism.
Topics: Humans; Imidazoles; Metabolic Networks and Pathways; Neoplasms; Purines | 1957 |
A comparison of the metabolism of purines and purine analogs by susceptible and drug-resistant bacterial and neoplastic cells.
Topics: Bacteria; Metabolic Networks and Pathways; Neoplasms; Purines | 1957 |
[Possibility of chemotherapy for neoplasms with pyrimidine & purine antagonists].
Topics: Antimetabolites; Humans; Neoplasms; Purines; Pyrimidines | 1957 |
Purine metabolism in mouse ascites tumor cells. 1. Effect of performed purines on in vitro incorporation of glycine-2-C14.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Glycine; In Vitro Techniques; Metabolic Networks and Pat | 1958 |
Purine metabolism in mouse ascites tumor cells. II. In vitro incorporation of performed purines into nucleotides and polynucleotides.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; In Vitro Techniques; Metabolic Networks and Pathways; Mi | 1958 |
Purine metabolism in mouse ascites tumor cells. III. In vivo incorporation of preformed purines into nucleotides and polynucleotides.
Topics: Animals; Ascites; Carcinoma, Ehrlich Tumor; Metabolic Networks and Pathways; Mice; Neoplasms; Nucleo | 1958 |
Effect of glucose and various nucleosides on purine synthesis by Ehrlich ascites tumor cells in vitro.
Topics: Animals; Carcinoma, Ehrlich Tumor; Catabolite Repression; Encephalomyelitis; Formates; Glucose; In V | 1958 |
Effects of A-methopterin on the purine biosynthesis of susceptible and resistant TA3 ascites cells.
Topics: Ascites; Encephalomyelitis; Folic Acid Antagonists; Metabolic Networks and Pathways; Neoplasms; Puri | 1958 |
Utilization of host purines by transplanted tumors.
Topics: Aged; Encephalomyelitis; Humans; Neoplasm Transplantation; Neoplasms; Purines | 1959 |
Purine synthesis in mouse tissues.
Topics: Animals; Encephalomyelitis; Metabolic Networks and Pathways; Mice; Neoplasms; Purines | 1959 |
[Changes of purine content and metabolism in nucleic acids during aging of experimental tumors].
Topics: Neoplasms; Nucleic Acids; Purines | 1959 |
Effects of 4-aminopyrazolo (3,4-d)pyrimidine and 1-methyl-4-aminopyrazolo(3,4-d)pyrimidine on nucleic acid purine metabolism in ascites tumors.
Topics: Adenine; Ascites; Neoplasms; Nucleic Acids; Purines; Pyrimidines | 1961 |
Inhibition of the biosynthesis of purines de novo by 6-chloropurine and azaserine in sensitive and naturally resistant ascites cells.
Topics: Antineoplastic Agents; Ascites; Azaserine; Neoplasms; Purines | 1960 |
Utilization of preformed purines by sarcoma 180 or hepatoma 134 cells treated with 6-chloropurine or a combination of 6-chloropurine and azaserine.
Topics: Animals; Antineoplastic Agents; Azaserine; Carcinoma, Hepatocellular; Liver Neoplasms; Neoplasms; Pu | 1960 |
Studies of purine metabolism in neoplastic diseases.
Topics: Humans; Leukemia; Metabolic Networks and Pathways; Neoplasms; Purines | 1961 |
Searches for exploitable biochemical differences between normal and cancer cells. VI. Metabolism of purines in vivo.
Topics: Humans; Metabolic Networks and Pathways; Neoplasms; Purines | 1961 |
Searches for exploitable biochemical differences between normal and cancer cells. VII. Anabolism and catabolism of purines by minced tissues.
Topics: Humans; Metabolic Networks and Pathways; Neoplasms; Purines | 1961 |
Searches for exploitable biochemical differences between normal and cancer cells. VIII. Catabolism of purines and purine nucleotides by sonicates.
Topics: Neoplasms; Nucleosides; Nucleotides; Purine Nucleotides; Purines | 1961 |
The metabolism of purines by tumors.
Topics: Biochemical Phenomena; Neoplasms; Purines | 1960 |
Searches for exploitable biochemical differences between normal and cancer cells. V. Cellular conservation of purines.
Topics: Formates; Neoplasms; Purines; Sarcoma | 1960 |
Distribution of methylated purines in cell fractions from mouse liver and tumor.
Topics: Biochemical Phenomena; Liver; Neoplasms; Purines | 1959 |
The effect of some purine deoxyribosides on the incorporation of [14C] formate and [32P] orthophosphate into DNA of ascites tumor cells in vitro.
Topics: Ascites; DNA; Formates; In Vitro Techniques; Neoplasms; Nucleosides; Nucleotides; Phosphates; Purine | 1960 |
Effect of 2-amino-6-[(1-methyl-4-nitro-5-imidazoly)thio] purine (B.W. 57-323) on neoplastic disease in man.
Topics: Humans; Male; Neoplasms; Purines | 1960 |
Feedback inhibition of purine biosynthesis in ascites tumor cells.
Topics: Ascites; Diploidy; Metabolic Networks and Pathways; Neoplasms; Purines | 1962 |
Conservation of nucleic acids by Ehrlich ascites-tumor cells. II. Conservation of ribonucleic acid purines.
Topics: Ascites; Neoplasms; Nucleic Acids; Purines; RNA | 1962 |
Use of nucleosides in resistance to 6-thioguanine.
Topics: Neoplasms; Neoplasms, Experimental; Nucleosides; Purines; Thioguanine | 1963 |
[On nucleic acids].
Topics: DNA; Fluorouracil; Metabolism; Neoplasms; Nucleic Acids; Proteins; Purines; Pyrimidines; Radiation E | 1963 |
Occurrence and distribution of methylated purines in the ribonucleic acids of subcellular fractions.
Topics: Neoplasms; Purines; RNA; RNA, Neoplasm; Subcellular Fractions | 1962 |
Augmentation of the incorporation of hypoxanthine into nucleic acids by the administration of an inhibitor of xanthine oxidase.
Topics: DNA; Hypoxanthine; Liver; Neoplasms; Nucleic Acids; Oxidoreductases; Purines; RNA; Xanthine Oxidase | 1963 |
SOME FACTORS AFFECTING THE TUMOR-INHIBITORY PROPERTIES OF COMBINATIONS OF AZASERINE AND 6-CHLOROPURINE.
Topics: Animals; Antineoplastic Agents; Azaserine; Mice; Neoplasms; Pharmacology; Purines; Research; Sarcoma | 1963 |
BIOCHEMICAL EFFECTS OF DUAZOMYCIN A IN THE MOUSE PLASMA CELL NEOPLASM 70429.
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Autoradiography; Azaserine; Azo Compounds; Carbon Isot | 1963 |
COMPARATIVE CLINICAL TOXICITY OF 6-MERCAPTOPURINE (NSC-755)-1 AND 6-MERCAPTOPURINE RIBONUCLEOSIDE (NSC-4911)-2 ADMINISTERED INTRAVENOUSLY TO PATIENTS WITH ADVANCED CANCER.
Topics: Bone Marrow; Injections, Intravenous; Leukopenia; Mercaptopurine; Mice; Neoplasms; Nucleosides; Phar | 1964 |
INDUCTION OF LAMBDA-BACTERIOPHAGE IN ESCHERICHIA COLI AS A SCREENING TEST FOR POTENTIAL ANTITUMOR AGENTS.
Topics: Alkylating Agents; Amino Acids; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antineoplastic A | 1964 |
[TREATMENT OF LEUKEMIA].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Cyclophosphamide; Humans; Leukemia; Neoplasms; Predn | 1964 |
FLUORINE-CONTAINING POTENTIAL ANTICANCER AGENTS. II. SYNTHESES OF SOME TRIFLUOROMETHYLPURINES AND TRIFLUOROMETHYLTHIAZOLOPYRIMIDINES.
Topics: Antineoplastic Agents; Chemistry, Pharmaceutical; Fluorine; Mice; Neoplasms; Neoplasms, Experimental | 1964 |
NEW PROSPECTS IN CANCER BIOCHEMISTRY.
Topics: Antineoplastic Agents; Carbohydrate Metabolism; Carcinoma, Hepatocellular; Feedback; Glucose; Glucos | 1963 |
TERATOGENESIS: EFFECTS OF SUBSTITUTED PURINES AND THE INFLUENCE OF 4-HYDROXYPYRAZOLOPYRIMIDINE IN THE RAT.
Topics: Abnormalities, Drug-Induced; Adenine; Female; Mercaptopurine; Neoplasms; Neoplasms, Experimental; Ph | 1964 |
[EFFECT OF PUROMYCIN AND AMINONUCLEOSIDE ON PURINE BIOSYNTHESIS].
Topics: Animals; Carcinoma; Carcinoma, Ehrlich Tumor; Mice; Neoplasms; Neoplasms, Experimental; Nucleosides; | 1964 |
GROWTH INHIBITION OF CLOSTRIDIUM FESERI BY CARCINOSTATIC PURINE AND PYRIMIDINE ANALOGS. I. EFFECT OF MEDIUM ON GROWTH INHIBITION.
Topics: Adenocarcinoma; Antineoplastic Agents; Clostridium; Culture Media; Neoplasms; Neoplasms, Experimenta | 1964 |
METABOLIC STUDIES ON THE SUGARS OF NUCLEIC ACIDS. I. THE ISOLATION OF PYRIMIDINE-BOUND SUGARS AND UTILIZATION OF (14C6)GLUCOSE FOR RIBOSE FORMATION IN MAMMALIAN TISSUES IN VITRO.
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; Glucose; In Vitro Techniques; Liver; Mic | 1964 |
METABOLISM OF PURINE NUCLEOSIDE ANALOGS.
Topics: Adenine; Animals; Antimetabolites; Guanine; Mercaptopurine; Metabolism; Mice; Neoplasms; Neoplasms, | 1965 |
EFFECT OF PURINOYL HUMAN SERUM ALBUMIN ON TRANSPLANTED EHRLICH ASCITES TUMOUR IN MICE.
Topics: Animals; Antibody Formation; Carcinoma; Carcinoma, Ehrlich Tumor; Injections, Intraperitoneal; Mice; | 1965 |
9-BETA-D-ARABINOFURANOSYLADENINE AS AN INHIBITOR OF METABOLISM IN NORMAL AND NEOPLASTIC CELLS.
Topics: Carbon Isotopes; DNA; DNA, Neoplasm; Injections, Intraperitoneal; Liver; Metabolism; Mice; Neoplasms | 1965 |
SYNTHESIS AND ANTITUMOR ACTIVITY OF 9-SUBSTITUTED NITROGEN MUSTARD DERIVATIVES OF 6-ALKYLTHIOPURINES.
Topics: Animals; Chemistry, Pharmaceutical; Mechlorethamine; Mice; Neoplasms; Neoplasms, Experimental; Nitro | 1965 |
[ELIMINATION OF PURINE BASES DURING ROENTGEN IRRADIATION AND CYTOSTATIC TREATMENT OF CANCER OF THE FEMALE GENITALIA].
Topics: Antineoplastic Agents; Female; Genital Neoplasms, Female; Genitalia, Female; Humans; Neoplasms; Puri | 1964 |
XANTHINE AS A PRECURSOR OF NUCLEIC ACID PURINES IN THE MOUSE.
Topics: Animals; Chromatography; DNA; DNA, Neoplasm; Metabolism; Mice; Neoplasms; Pharmacology; Purines; Pyr | 1965 |
Effects of 6-mercaptopurine and analogs on experimental tumors.
Topics: Humans; Mercaptopurine; Neoplasms; Neoplasms, Experimental; Purines | 1954 |
Clinical studies on 6-mercaptopurine.
Topics: Mercaptopurine; Neoplasms; Purines | 1954 |
Clinical experience with 6-mercaptopurine in human neoplasia.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
Summary of experience with 6-mercaptopurine.
Topics: Mercaptopurine; Neoplasms; Purines | 1954 |
6-Mercaptopurine therapy in neoplastic disease.
Topics: Mercaptopurine; Neoplasms; Purines | 1954 |
Clinical observations of the treatment of leukemia and allied disorders with 6-mercaptopurine.
Topics: Arylsulfonates; Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
Treatment of leukemia and related disorders with 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
The therapeutic effect of mercaptopurine in a variety of human neoplastic diseases.
Topics: Mercaptopurine; Neoplasms; Purines | 1954 |
Role of mercaptopurine in the treatment of leukemia and related diseases.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
A clinical study of 6-mercaptopurine.
Topics: Biomedical Research; Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
Effect of aminopterin and certain purine antagonists on adenine nucleotide levels in tissues of tumor-bearing mice.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Aminopterin; Animals; Mice; Neoplasms; Nucleotides; Pur | 1955 |
Incorporation of glycine-2-C14 into ascites tumor-cell purines as a biological test system.
Topics: Ascites; Glycine; Neoplasms; Nucleic Acids; Purines | 1955 |
Purine biosynthesis de novo in mouse tissues and a mouse tumor.
Topics: Animals; Metabolic Networks and Pathways; Metabolism; Mice; Neoplasms; Purines | 1959 |
Investigations of the DNA content, base composition and chromatography on ECTEOLA-cellulose of normal and tumor DNA preparations.
Topics: Base Composition; Cellulose; Chromatography; DNA; Neoplasms; Purines | 1960 |
Observations on the site of 6-chloropurine-induced inhibition of purine biosynthesis.
Topics: Biochemical Phenomena; Metabolic Networks and Pathways; Neoplasms; Purines | 1962 |
Studies on 2,6-diaminopurine and related substances in cultures of embryonic and sarcomatous rodent tissues.
Topics: 2-Aminopurine; Humans; Neoplasms; Purines; Sarcoma | 1951 |
The effects of the folic acid antagonists and 2,6-diaminopurine on neoplastic disease, with special reference to acute leukemia.
Topics: 2-Aminopurine; Folic Acid Antagonists; Leukemia; Neoplasms; Purines | 1951 |
In vivo studies on incorporation of glycine-2-C14 into proteins and nucleic acid purines.
Topics: Glycine; Neoplasms; Nucleic Acids; Proteins; Purines | 1952 |
Effects of tumors on nucleic acids and their purine constituents in the mouse.
Topics: Animals; Metabolic Networks and Pathways; Mice; Neoplasms; Nucleic Acids; Purines; Sarcoma; Sarcoma, | 1952 |
Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
Topics: Adenine; Adenosine Triphosphate; Bone and Bones; Carbon; Catalytic Domain; Cyclin-Dependent Kinase 2 | 2006 |
Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase.
Topics: Animals; Avian Proteins; Binding Sites; Birds; Enzyme Inhibitors; Humans; Neoplasm Proteins; Neoplas | 2007 |