purine has been researched along with Leukemia in 86 studies
1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 84 (97.67) | 18.7374 |
| 1990's | 1 (1.16) | 18.2507 |
| 2000's | 1 (1.16) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BURCHENAL, JH | 7 |
| MURPHY, ML | 2 |
| ELLISON, RR | 2 |
| SYKES, MP | 2 |
| TAN, TC | 1 |
| LEONE, LA | 1 |
| KARNOFSKY, DA | 3 |
| CRAVER, LF | 2 |
| DARGEON, HW | 2 |
| RHOADS, CP | 4 |
| BERNARD, J | 2 |
| DELTOUR, G | 1 |
| HALL, BE | 2 |
| RICHARDS, MD | 2 |
| WILLETT, FM | 2 |
| FEICHTMEIR, TV | 2 |
| AGGELER, PM | 1 |
| SCHMIDT, KH | 1 |
| TAN, CT | 1 |
| MERMANN, AC | 1 |
| YUCEOGLU, M | 1 |
| SHAY, H | 1 |
| GRUENSTEIN, M | 1 |
| ATWATER, J | 1 |
| HAYHOE, FG | 1 |
| MARINHO, HM | 1 |
| POWELL, LW | 1 |
| HALL, SC | 1 |
| HOOKER, JW | 1 |
| GASSER, C | 1 |
| HITZIG, W | 1 |
| LENHARTZ, H | 1 |
| WHITELAW, DM | 1 |
| MOFFAT, RG | 1 |
| PERRY, WH | 1 |
| BECK, RE | 1 |
| KARAMCHANDANI, PV | 1 |
| GHARPURE, VV | 1 |
| NAIDU, VR | 1 |
| MOYNIHAN, JW | 1 |
| BERMAN, L | 1 |
| DUBOIS-FERRIERE, H | 1 |
| ZUMSTEIN, P | 1 |
| BOUVIER, C | 1 |
| KALACI, J | 1 |
| SORG, D | 1 |
| VAUTHIER, J | 1 |
| HAUSSER, A | 1 |
| REMY, D | 1 |
| GREIG, HB | 1 |
| METZ, J | 1 |
| LAIRD, MH | 1 |
| ZENTKOWSKY, D | 1 |
| FITZPATRICK, MM | 1 |
| NAKATA, I | 1 |
| TSUNEYOSHI, H | 1 |
| OLSSON, G | 1 |
| GERHARTZ, H | 1 |
| KRAKOFF, IH | 2 |
| BALIS, ME | 1 |
| MAGILL, JW | 1 |
| NARY, D | 1 |
| ADAMS, WS | 2 |
| DAVIS, F | 1 |
| NAKATANI, M | 2 |
| SELAWRY, OS | 1 |
| VENDITTI, JM | 1 |
| FREI, E | 1 |
| GOLDIN, A | 2 |
| BURDGE, DC | 1 |
| MANDEL, HG | 1 |
| HILGER, E | 1 |
| WHITTINGTON, RM | 2 |
| RIVERS, SL | 2 |
| DOYLE, RT | 2 |
| KODLIN, D | 2 |
| WILMANNS, W | 1 |
| DAVIDSON, JD | 1 |
| BRADLEY, TR | 1 |
| ROOSA, RA | 1 |
| LAW, LW | 2 |
| HITCHINGS, GH | 1 |
| STRELIUKHINA, NV | 1 |
| FINK, K | 1 |
| DAVIS, FW | 1 |
| VANDEVOORDE, JP | 1 |
| HANSEN, HJ | 1 |
| NADLER, SB | 1 |
| WOODLIFF, HJ | 1 |
| CUTTS, JH | 1 |
| OTA, K | 1 |
| BOWLES, WA | 1 |
| SCHNEIDER, FH | 1 |
| LEWIS, LR | 1 |
| ROBINS, RK | 1 |
| CRESSWELL, RM | 1 |
| STRAUSS, T | 1 |
| BROWN, GB | 1 |
| SAWITSKY, A | 2 |
| RUOHANI, J | 1 |
| LEVY, RN | 1 |
| FAHMY, OG | 1 |
| FAHMY, MJ | 1 |
| HALIKOWSKI, B | 1 |
| ARMATA, J | 1 |
| GARWICZ, S | 1 |
| ALVSAKER, JO | 1 |
| BICHEL, J | 1 |
| BJORNJENSEN, K | 1 |
| THORLING, EB | 1 |
| BLIS, ME | 1 |
| LYMAN, MS | 1 |
| OEHME, J | 2 |
| TAORMINA, V | 1 |
| BOYLE, PJ | 1 |
| BROSS, ID | 1 |
| SELIGMANN, M | 1 |
| JIMENEZ DE ASUA, F | 1 |
| DOAN, CA | 1 |
| WISEMAN, K | 1 |
| BOURONCLE, B | 1 |
| PIERCE, M | 2 |
| FOUNTAIN, JR | 2 |
| BETHELL, FH | 1 |
| THOMPSON, DS | 1 |
| DAMESHEK, W | 1 |
| ROSENTHAL, N | 1 |
| ROSENTHAL, RL | 1 |
| LEE, SL | 1 |
| SYDENSTRICKER, VP | 1 |
| RICE, EC | 1 |
| HILL, JM | 1 |
| LAJOUS, J | 1 |
| LOZNER, EL | 1 |
| NEWTON, WA | 1 |
| REAM, CR | 1 |
| GAFFNEY, PC | 1 |
| COOPER, WM | 1 |
| DEMARSH, QB | 1 |
| PETRAKIS, NL | 1 |
| WOOD, DA | 1 |
| METTIER, SR | 1 |
| DEAMER, WC | 1 |
| GELLERT, SA | 1 |
| LI, JG | 1 |
| LEONARD, ME | 1 |
| WILSON, SJ | 1 |
| ROUQUES, L | 1 |
| LENZI, G | 1 |
| SCHRECKER, AW | 1 |
| MEAD, JA | 1 |
| LYNCH, MR | 1 |
| LEIKIN, SL | 1 |
| PARK, RW | 1 |
| HOLLAND, JF | 1 |
| JENKINS, A | 1 |
| HALL, J | 1 |
| OZOA, N | 1 |
| KINGSLEY-PILLERS, EM | 1 |
| SOUTHAM, CM | 1 |
| MYERS, WP | 1 |
| ESCHER, GC | 1 |
| SKIPPER, HE | 1 |
| BENNETT, LL | 1 |
| Lamanna, N | 1 |
| Weiss, M | 1 |
| Nakamura, T | 1 |
| Ueda, T | 1 |
1 review available for purine and Leukemia
| Article | Year |
|---|---|
Purine analogs in leukemia.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia; Pentostatin; Purines; Stem Cell Transplantation | 2004 |
85 other studies available for purine and Leukemia
| Article | Year |
|---|---|
[Therapy of acute leukemia].
Topics: Folic Acid Antagonists; Leukemia; Purines | 1952 |
Clinical evaluation of a new antimetabolite, 6-mercaptopurine, in the treatment of leukemia and allied diseases.
Topics: Antimetabolites; Leukemia; Mercaptopurine; Purines | 1953 |
[New therapy of leukoses; triethylene phosphoramide; G. T. 41 (myleran); 6-mercaptopurine; beta-mercaptoethylamine; massive doses of cortisone].
Topics: Busulfan; Cortisone; Cysteamine; Ethylamines; Leukemia; Mercaptopurine; Phosphoramides; Phosphorus; | 1953 |
Evaluation of 6-mercaptopurine in the treatment of leukemia; a preliminary report.
Topics: Leukemia; Mercaptopurine; Purines | 1953 |
[Experimental and comparative results with triethylene melamine, N,N',N"-triethylene phosphoramide and 6-mercaptopurine].
Topics: Animals; Leukemia; Leukemia, Experimental; Mercaptopurine; Mitosis; Neoplasms, Experimental; Phospho | 1954 |
Clinical evaluation of 6-mercaptopurine in the treatment of leukemia.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Clinical effects of analogs of folic acid, purines, pyrimidines, and amino acids.
Topics: Amino Acids; Folic Acid; Folic Acid Antagonists; Humans; Inorganic Chemicals; Leukemia; Purines; Pyr | 1954 |
Clinical evaluation of 6-mercaptopurine in the treatment of leukemia.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Effect of triethylene thiophosphoramide and 6-mercaptopurine in chronic myelogenous and in an acute leukemia in rats.
Topics: Animals; Leukemia; Leukemia, Experimental; Mercaptopurine; Phosphorus; Purines; Rats; Thiotepa | 1955 |
6-Mercaptopurine in acute leukaemia.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1955 |
[A synthetic antileukemic agent, 6-mercaptopurine].
Topics: Antineoplastic Agents; Leukemia; Mercaptopurine; Purines | 1955 |
Acute monocytic leukemia: report of a case treated with cortisone and 6-mercaptopurine.
Topics: Cortisone; Leukemia; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Mercaptopurine; Purines | 1956 |
[6-Mercaptopurine (purinethol) in the treatment of leukemia in children; comparison with cortisone and aminopterin].
Topics: Aminopterin; Child; Cortisone; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1955 |
[Purinethol treatment of acute myeloblastic leukemia].
Topics: Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Mercaptopurine; Purines | 1955 |
Acute leukaemia in adults treated with 6-mercaptopurine.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1956 |
NEW AND nonofficial remedies.
Topics: Hypnotics and Sedatives; Leukemia; Leukemia, Myeloid; Purines; Succinates; Veratrum Alkaloids | 1956 |
6-Mercaptopurine in acute lymphocytic leukaemia.
Topics: Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1956 |
Acute leukemia in adults; treatment with the combined use of ACTH or cortisone and 6 mercaptopurine.
Topics: Acute Disease; Adrenocorticotropic Hormone; Cortisone; Leukemia; Mercaptopurine; Purines | 1956 |
[Cortisone in massive doses and 6-mercaptopurine in the treatment of acute leucemias in adult; possibility of producing successive remissions].
Topics: Cortisone; Leukemia; Mercaptopurine; Neoplasms; Purines | 1956 |
[6-Mercaptopurine (purinethol) in therapy of myeloid leukemia].
Topics: Humans; Leukemia; Leukemia, Myeloid; Mercaptopurine; Purines | 1956 |
Chemotherapy of leukaemia. II. 6-Mercaptopurine (purinethol) in the treatment of acute leukaemia and some other neoplastic diseases of the reticuloendothelial system.
Topics: Leukemia; Mercaptopurine; Mononuclear Phagocyte System; Neoplasms; Purines | 1956 |
Studies on the uric acid and non-uric acid purine in leukemic patients.
Topics: Biochemical Phenomena; Humans; Leukemia; Purines; Uric Acid | 1956 |
[Acute leukemia in children treated with meticorten & purinethol].
Topics: Acute Disease; Child; Humans; Infant; Leukemia; Mercaptopurine; Prednisone; Purines | 1959 |
[On the chemotherapy of acute leukoses with recent purine antagonists].
Topics: Antimetabolites; Humans; Leukemia; Purines | 1961 |
Studies of purine metabolism in neoplastic diseases.
Topics: Humans; Leukemia; Metabolic Networks and Pathways; Neoplasms; Purines | 1961 |
Purine and pyrimidine excretion in normal and leukemic subjects.
Topics: Humans; Leukemia; Purines; Pyrimidines | 1960 |
Effect of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio]purine (imidazolylthioguanine; B.W. 57-323) on acute leukemia in man.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1960 |
The effectiveness of 2-amino-6-[(1-methyl-4-nitro-5-imidazolyl)thio] purine against transplantable mouse leukemia.
Topics: Animals; Leukemia; Leukemia, Experimental; Mercaptopurine; Purines | 1960 |
The differential effect of 8-azaguanine on nucleic acid and protein biosynthesis of leukemia L1210.
Topics: Animals; Antineoplastic Agents; Azaguanine; Leukemia; Leukemia L1210; Nucleic Acids; Protein Biosynt | 1962 |
[Forms of leukosis and their therapy].
Topics: Adrenocorticotropic Hormone; Antineoplastic Agents; Busulfan; Colchicine; Folic Acid Antagonists; Go | 1963 |
Acute leukemia in the adult male. I. Comparative effect of 6-mercaptopurine and 6-chloropurine.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1963 |
[On the mechanism of action of folic acid and purine antagonists in the treatment of acute leukemias].
Topics: Antimetabolites; Folic Acid; Leukemia; Purines | 1963 |
Acute leukemia in the adult male. I. Comparative effect of 6-mercaptopurine and 6-chloropurine.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1962 |
Purine nucleotide pyrophosphorylases in 8-azaguanine-sensitive and-resistant P388 leukemias.
Topics: Animals; Azaguanine; Leukemia; Leukemia P388; Leukemia, Experimental; Nucleotidyltransferases; Purin | 1962 |
SUMMARY OF INFORMAL DISCUSSION ON THE ROLE OF PURINE ANTAGONISTS.
Topics: Antimetabolites; Gout; Humans; Leukemia; Mercaptopurine; Pharmacology; Psoriasis; Purines; Pyrazoles | 1963 |
[ON PURINE METABOLISM IN LEUKOSES].
Topics: Blood Chemical Analysis; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Lymphocytes; Metab | 1963 |
THE IDENTIFICATION OF 2-DIMETHYLAMINO-6- HYDROXYPURINE AND ITS RIBONUCLEOSIDE IN URINE OF NORMAL AND LEUKEMIC SUBJECTS.
Topics: Chromatography; Electrophoresis; Guanine; Humans; Leukemia; Nucleosides; Purines; Ribonucleosides; R | 1963 |
METABOLISM OF LEUKEMIC CELLS IN CULTURE; AZASERINE INHIBITION OF J-128 (OSGOOD).
Topics: Adenine; Azaserine; Carbon Isotopes; Glycine; Guanine; Hypoxanthines; Imidazoles; Leukemia; Metaboli | 1964 |
IN-VITRO SENSITIVITY TESTS OF LEUKAEMIC CELLS TO CHEMOTHERAPEUTIC AGENTS.
Topics: Aminopterin; Animals; Antineoplastic Agents; Busulfan; Chlorambucil; Cyclophosphamide; Geriatrics; H | 1964 |
EFFECTS OF OTHER AGENTS ON THE BIOLOGIC RESPONSES TO VINCALEUKOBLASTINE.
Topics: 2-Aminopurine; Aminopterin; Animals; Aspartic Acid; Azaguanine; Biological Products; Colchicine; Cor | 1964 |
[TREATMENT OF LEUKEMIA].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; Cyclophosphamide; Humans; Leukemia; Neoplasms; Predn | 1964 |
SYNTHESIS AND ANTITUMOR ACTIVITY OF 9-(TETRAHYDRO-2-FURYL)PURINE ANALOGS OF BIOLOGICALLY IMPORTANT DEOXYNUCLEOSIDES.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Furans; Leukemia; Leukemi | 1963 |
SOME 2-SUBSTITUTED AMINOPURINES AND PURINE ANALOGS.
Topics: 2-Aminopurine; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Leukemia; Leukemia, Experi | 1963 |
DRUG FEVER PRODUCED BY SIX-MERCAPTOPURINE.
Topics: Adenine; Antineoplastic Agents; Drug Therapy; Fever; Hematocrit; Leukemia; Leukocyte Count; Mercapto | 1964 |
MUTAGENICITY OF IONIC POLYMERS AND LEUKAEMOGENIC VIRUSES RELATIVE TO NUCLEIC ACIDS IN DROSOPHILA MELANOGASTER.
Topics: Amino Acids; Animals; Blood Proteins; Chromosomes; DNA; Drosophila; Drosophila melanogaster; Glutama | 1964 |
TREATMENT OF LEUKAEMIA BY AMINOACID IMBALANCE.
Topics: Child; Diet; Diet Therapy; Dietary Proteins; Humans; Leukemia; Prognosis; Purines | 1965 |
URIC ACID IN HUMAN PLASMA. I. INVESTIGATIONS ON THE PRESENCE OF PURINES IN HUMAN BLOOD.
Topics: Blood; Colorimetry; Gout; Humans; Hypoxanthines; Leukemia; Liver Cirrhosis; Oxidoreductases; Purines | 1965 |
ON THE EFFECT OF BUTHIOPURINE IN ACUTE LEUKAEMIA.
Topics: Antineoplastic Agents; Drug Therapy; Humans; Leukemia; Leukemia, Myeloid; Mercaptopurine; Prognosis; | 1964 |
STUDIES OF URIC ACID BIOSYNTHESIS IN CHRONIC LEUKEMIA.
Topics: Blood Chemical Analysis; Carbon Isotopes; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; M | 1964 |
LACK OF CROSS RESISTANCE TO THE AMIDINO AND THE UREIDO DERIVATIVES IN MOUSE LEUKEMIAS MADE RESISTANT TO 4',4"-BIS(2-IMIDAZOLIN-2-YL)-2-CHLOROTEREPHTHALANILIDE DIHYDROCHLORIDE (NSC 38280).
Topics: Anilides; Animals; Antineoplastic Agents; Folic Acid Antagonists; Imidazoles; Leukemia; Leukemia, Ex | 1963 |
[Purinethol therapy leukoses of childhood].
Topics: Child; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1955 |
Response of acute lymphocytic leukemias to the purine antagonist 6-mercaptopurine.
Topics: Acute Disease; Humans; Leukemia; Leukemia, Lymphoid; Mercaptopurine; Precursor Cell Lymphoblastic Le | 1954 |
Statistical analysis of clinical results from 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Clinical experience with 6-mercaptopurine in human neoplasia.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
A study of 61 leukemias treated with 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
The treatment of blastic leukemias with 6-mercaptopurine.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1954 |
One-year evaluation of 6-mercaptopurine in the treatment of leukemia.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Leukemia in children: treatment of 22 cases with 6-mercaptopurine.
Topics: Child; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1954 |
Clinical observations of the treatment of leukemia and allied disorders with 6-mercaptopurine.
Topics: Arylsulfonates; Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
Treatment of leukemia and related disorders with 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
The use of 6-mercaptopurine in acute leukemia.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1954 |
Role of mercaptopurine in the treatment of leukemia and related diseases.
Topics: Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
Report on 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
Results obtained in the treatment of acute leukemia and lymphosarcoma with 6-mercaptopurine.
Topics: Humans; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Mercaptopurine; Purines | 1954 |
6-Mercaptopurine therapy in leukemia.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
6-Mercaptopurine in acute leukemia.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1954 |
Clinical experience using 6-mercaptopurine in childhood leukemia.
Topics: Child; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1954 |
Clinical evaluation of 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
A clinical study of 6-mercaptopurine.
Topics: Biomedical Research; Leukemia; Mercaptopurine; Neoplasms; Purines | 1954 |
The treatment of leukemia with 6-mercaptopurine.
Topics: Leukemia; Mercaptopurine; Purines | 1954 |
The effect of 6-mercaptopurine in acute leukemia of children and adults: a preliminary report.
Topics: Acute Disease; Leukemia; Mercaptopurine; Purines | 1954 |
The clinical and hematological response of previously treated leukemic subjects to the antimetabolite 6-mercaptopurine.
Topics: Antimetabolites; Leukemia; Mercaptopurine; Purines | 1954 |
MERCAPTOPURINE in leukemia.
Topics: Humans; Leukemia; Mercaptopurine; Purines | 1955 |
[Treatment of leukemia with a new purine antimetabolite, 6-mercpatopurine].
Topics: Antimetabolites; Leukemia; Purines | 1954 |
Treatment of leukaemia and allied disorders with 6-mercaptopurine.
Topics: Arylsulfonates; Leukemia; Mercaptopurine; Purines | 1955 |
[Recent treatment of acute leukemia in children and its results].
Topics: Acute Disease; Adrenocorticotropic Hormone; Child; Cortisone; Infant; Leukemia; Purines | 1955 |
[6-Mercaptopurine in therapy of leukemia].
Topics: Leukemia; Mercaptopurine; Purines | 1955 |
[Early impressions of a case of acute infantile leukemia during 6-mercaptopurine therapy].
Topics: Acute Disease; Child; Humans; Infant; Leukemia; Mercaptopurine; Purines | 1955 |
Comparative effect of amethopterin and its 3',5'-dichloro derivative on purine biosynthesis in leukemic mice.
Topics: Animals; Folic Acid Antagonists; Leukemia; Metabolic Networks and Pathways; Methotrexate; Mice; Puri | 1960 |
Leukemia: current concepts in therapy.
Topics: Antineoplastic Agents; Folic Acid Antagonists; Humans; Leukemia; Purines; Steroids | 1962 |
Urinary purines in leukemia.
Topics: Humans; Leukemia; Purines | 1962 |
The effect of 6-mercaptopurine riboside in 20 cases of childhood leukemia previously treated with purine antimetabolites.
Topics: Antimetabolites; Child; Humans; Infant; Leukemia; Mercaptopurine; Purines; Thioinosine | 1961 |
The effects of the folic acid antagonists and 2,6-diaminopurine on neoplastic disease, with special reference to acute leukemia.
Topics: 2-Aminopurine; Folic Acid Antagonists; Leukemia; Neoplasms; Purines | 1951 |
Anti-leukemic assays on certain pyrimidines, purines, benzimidazoles, and related compounds.
Topics: Benzimidazoles; Humans; Leukemia; Purines; Pyrimidines | 1950 |
[Mechanism of action of anti-leukemia agents and adverse effects].
Topics: Antineoplastic Agents; Bone Marrow Cells; Depression, Chemical; DNA, Neoplasm; Folic Acid Antagonist | 1992 |