purine has been researched along with Inflammation in 11 studies
1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.
Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hypothalamic dysfunction is a key factor in depression; increasing evidence highlights neuroinflammation abnormalities as well as imbalances in neurotransmitters and the purinergic system in the pathophysiology of depression." | 7.85 | Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS. ( Gao, X; Guo, R; Jia, J; Jia, Y; Li, Y; Qi, X; Wei, C; Wu, Y; Xu, H, 2017) |
| " Because massive extracellular release of ATP often occurs by lytic and non-lytic mechanisms, especially after stressful events and pathological conditions, purinergic signalling is correlated to and involved in the aetiopathology and/or progression of many neurodegenerative diseases." | 4.85 | Membrane compartments and purinergic signalling: P2X receptors in neurodegenerative and neuroinflammatory events. ( Amadio, S; Apolloni, S; Finocchi, P; Montilli, C, 2009) |
| "Purine not only acts as a metabolic substrate of XOR for UA production, but it induces inflammation through IFN-γ secretion that stimulates UA production through elevation of XOR expression." | 4.12 | Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression. ( Huang, D; Li, X; Liang, B; Lin, Z; Song, X; Su, T; Wang, H; Wang, J; Xie, L, 2022) |
| "Hypothalamic dysfunction is a key factor in depression; increasing evidence highlights neuroinflammation abnormalities as well as imbalances in neurotransmitters and the purinergic system in the pathophysiology of depression." | 3.85 | Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS. ( Gao, X; Guo, R; Jia, J; Jia, Y; Li, Y; Qi, X; Wei, C; Wu, Y; Xu, H, 2017) |
| " In addition, we identified specific metabolites that may contribute to early renal injury response, perturbed energy metabolism, impaired purine metabolism, impacted osmotic regulation and the induction of inflammation." | 3.80 | Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion. ( Dong, Z; Fogle, P; Wei, Q; Xiao, X, 2014) |
| "Co-treatment with quercetin reduces pyruvate concentrations compared to TNFα-only treated controls." | 1.62 | Anti-Inflammatory Effects of Quercetin on High-Glucose and Pro-Inflammatory Cytokine Challenged Vascular Endothelial Cell Metabolism. ( Kroon, PA; Le Gall, G; Needs, PW; Ozyel, B, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, H | 1 |
| Xie, L | 1 |
| Song, X | 1 |
| Wang, J | 1 |
| Li, X | 1 |
| Lin, Z | 1 |
| Su, T | 1 |
| Liang, B | 1 |
| Huang, D | 1 |
| Nomura, J | 1 |
| Kobayashi, T | 1 |
| So, A | 1 |
| Busso, N | 1 |
| Ozyel, B | 1 |
| Le Gall, G | 1 |
| Needs, PW | 1 |
| Kroon, PA | 1 |
| Wu, Y | 1 |
| Li, Y | 2 |
| Jia, Y | 1 |
| Wei, C | 1 |
| Xu, H | 1 |
| Guo, R | 1 |
| Jia, J | 1 |
| Qi, X | 1 |
| Gao, X | 1 |
| Maugé, L | 1 |
| Fotopoulou, T | 1 |
| Delemasure, S | 1 |
| Dutartre, P | 1 |
| Koufaki, M | 1 |
| Connat, JL | 1 |
| Wei, Q | 1 |
| Xiao, X | 1 |
| Fogle, P | 1 |
| Dong, Z | 1 |
| Kocic, G | 1 |
| Veljkovic, A | 1 |
| Kocic, H | 1 |
| Colic, M | 1 |
| Mihajlovic, D | 1 |
| Tomovic, K | 1 |
| Stojanovic, S | 1 |
| Smelcerovic, A | 1 |
| Apolloni, S | 1 |
| Montilli, C | 1 |
| Finocchi, P | 1 |
| Amadio, S | 1 |
| Chang, CZ | 1 |
| Wu, SC | 1 |
| Lin, CL | 1 |
| Hwang, SL | 1 |
| Kwan, AL | 1 |
| Cersini, A | 1 |
| Martino, MC | 1 |
| Martini, I | 1 |
| Rossi, G | 1 |
| Bernardini, ML | 1 |
| Choi, HK | 1 |
| Mount, DB | 1 |
| Reginato, AM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Three Arms, Randomized, Double-blind Controlled Trial of the Efficacy of Amway Uric Acid Lowering Product on Hyperuricemia[NCT06084585] | 180 participants (Anticipated) | Interventional | 2023-10-23 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for purine and Inflammation
| Article | Year |
|---|---|
Membrane compartments and purinergic signalling: P2X receptors in neurodegenerative and neuroinflammatory events.
Topics: Animals; Humans; Inflammation; Neurodegenerative Diseases; Purines; Receptors, Purinergic P2; Recept | 2009 |
Pathogenesis of gout.
Topics: Cardiovascular Diseases; Crystallization; Diet; Gout; Humans; Hyperuricemia; Inflammation; Insulin R | 2005 |
9 other studies available for purine and Inflammation
| Article | Year |
|---|---|
Purine-Induced IFN-γ Promotes Uric Acid Production by Upregulating Xanthine Oxidoreductase Expression.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Hepatocytes; Humans; Inflammation; Interferon-gamma; Ju | 2022 |
Febuxostat, a Xanthine Oxidoreductase Inhibitor, Decreases NLRP3-dependent Inflammation in Macrophages by Activating the Purine Salvage Pathway and Restoring Cellular Bioenergetics.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Energy Metabolism; Febuxostat; Humans; Inflammas | 2019 |
Anti-Inflammatory Effects of Quercetin on High-Glucose and Pro-Inflammatory Cytokine Challenged Vascular Endothelial Cell Metabolism.
Topics: 5'-Nucleotidase; Adenosine Deaminase; Apyrase; Cytokines; Endothelium, Vascular; Energy Metabolism; | 2021 |
Imbalance in amino acid and purine metabolisms at the hypothalamus in inflammation-associated depression by GC-MS.
Topics: Amino Acids; Animals; Body Weight; Depression; Gas Chromatography-Mass Spectrometry; Hypothalamus; I | 2017 |
In vitro inflammatory/anti-inflammatory effects of nitrate esters of purines.
Topics: Anti-Inflammatory Agents; Caspase 1; Cell Line; Cell Survival; Esters; Humans; Inflammation; Interle | 2014 |
Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion.
Topics: Acute Kidney Injury; Animals; Cluster Analysis; Disease Models, Animal; Energy Metabolism; Glucose; | 2014 |
Depurinized milk downregulates rat thymus MyD88/Akt/p38 function, NF-κB-mediated inflammation, caspase-1 activity but not the endonuclease pathway: in vitro/in vivo study.
Topics: Animals; Caspase 1; Cattle; Diabetes Mellitus, Experimental; Endonucleases; Female; Gene Expression | 2017 |
Purine anti-metabolite attenuates nuclear factor κB and related pro-inflammatory cytokines in experimental vasospasm.
Topics: Animals; Cytokines; I-kappa B Proteins; Inflammation; Male; NF-kappa B; NF-KappaB Inhibitor alpha; P | 2012 |
Analysis of virulence and inflammatory potential of Shigella flexneri purine biosynthesis mutants.
Topics: Administration, Intranasal; Animals; Bacterial Proteins; Colony Count, Microbial; Disease Models, An | 2003 |