purine and Disease Models, Animal

Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Disease Models, Animal; DNA Damage; DNA Repair; Humans; Molecular Structure; Nucleosides; Purines; Pyrimidines; Radiation-Sensitizing Agents; Radiation, Ionizing; Radiotherapy; Xenograft Model Antitumor Assays

Topics: Animals; Central Nervous System; Disease Models, Animal; Humans; Hypothermia, Induced; Infant; Infant, Newborn; Molecular Targeted Therapy; Purinergic P2 Receptor Antagonists; Purines; Receptors, Purinergic P1; Receptors, Purinergic P2; Seizures

Topics: Adenine Phosphoribosyltransferase; Adenosine Deaminase; AMP Deaminase; Animals; Disease Models, Animal; Gout; Humans; Hyperuricemia; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Mice; Mice, Knockout; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Urate Oxidase; Xanthine Dehydrogenase

Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Hyperuricemia; Kidney Diseases; Mice; Phytotherapy; Purines; Rats; Uric Acid

Topics: Animals; B-Lymphocytes; Disease Models, Animal; DNA; Enzyme Inhibitors; Graft Rejection; Graft vs Host Disease; Guanosine Triphosphate; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Lymphocyte Activation; Membrane Glycoproteins; Mice; Muscle, Smooth, Vascular; Mycophenolic Acid; Organ Transplantation; Purines; Selectins; T-Lymphocytes; Transplantation, Homologous

Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central Nervous System; Deoxyuridine; Disease Models, Animal; Drug Interactions; Enzyme Activation; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Liver; Methionine; Methylmalonyl-CoA Mutase; Nitrous Oxide; Oxidation-Reduction; Pteroylpolyglutamic Acids; Purines; Serine; Tetrahydrofolates; Thymidylate Synthase; Vitamin B 12; Vitamin B 12 Deficiency

Topics: Animals; Biomarkers; Circadian Rhythm; Diet, High-Fat; Disease Models, Animal; Metabolome; Metabolomics; Mice; Obesity; Purines

Topics: Animals; Astroviridae Infections; Avastrovirus; Avian Proteins; Carrier Proteins; Disease Models, Animal; Feces; Geese; Gout; Kidney; Liver; Poultry Diseases; Purines; Uric Acid

Topics: Adenine; Amino Acids; Animals; Dietary Supplements; Disease Models, Animal; Disease Susceptibility; Fatty Liver; Hepatocytes; Metabolome; Metabolomics; Purines; Rats; Triglycerides

Topics: Animals; Bacterial Proteins; Disease Models, Animal; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Genetic Complementation Test; Genome, Bacterial; Humans; Klebsiella Infections; Klebsiella pneumoniae; Larva; Membrane Proteins; Moths; Mutagenesis; Polysaccharides; Purines; Siderophores; Virulence; Virulence Factors

Topics: Acute Disease; Adenosine Triphosphate; Animals; Autism Spectrum Disorder; Behavior, Animal; Body Temperature; Chemokines; Corticosterone; Disease Models, Animal; Energy Metabolism; Metabolomics; Mice, Inbred C57BL; Mitochondria; Purines

Topics: Animals; Carbon-Nitrogen Ligases; Cell Line, Tumor; Cell Proliferation; Cohort Studies; Computational Biology; Disease Models, Animal; Gene Knockdown Techniques; Glutamine; Humans; Male; Metabolic Networks and Pathways; Metabolomics; Mice; Prostatectomy; Prostatic Neoplasms; Purines; Tissue Array Analysis; Up-Regulation; Xenograft Model Antitumor Assays

Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Cellular Reprogramming; Computational Biology; Disease Models, Animal; Energy Metabolism; Gene Expression Profiling; Glycolysis; Heterografts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Metabolic Networks and Pathways; Metabolomics; Mice; Models, Biological; Pancreatic Neoplasms; Positron Emission Tomography Computed Tomography; Prognosis; Purine-Nucleoside Phosphorylase; Purines

Topics: Animals; Brazil; Catfishes; Disease Models, Animal; Fisheries; Fresh Water; Kidney; Kidney Tubules; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Purines; Reactive Oxygen Species; Streptococcal Infections; Streptococcus agalactiae; Uric Acid; Xanthine Oxidase

Topics: Animals; Bradycardia; Coronary Artery Disease; Death, Sudden, Cardiac; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Lysine; Metabolomics; Myocardial Ischemia; Purines; Rats

Topics: 5'-Nucleotidase; Animals; Cell Proliferation; Clonal Evolution; Disease Models, Animal; Drug Resistance, Neoplasm; Female; Gain of Function Mutation; Guanosine; HEK293 Cells; Humans; IMP Dehydrogenase; Male; Mercaptopurine; Mice; Mutation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purines; Receptor, Notch1; Recurrence; Xenograft Model Antitumor Assays

Topics: Administration, Oral; Animals; Brain; Cachexia; Disease Models, Animal; Febuxostat; Male; Mice, Inbred BALB C; Neoplasms; Purines; Xanthine Oxidase

Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Mice; Motor Activity; Pentylenetetrazole; Purines; Seizures

Topics: Acute Kidney Injury; Animals; Cluster Analysis; Disease Models, Animal; Energy Metabolism; Glucose; Inflammation; Kidney Function Tests; Lipid Metabolism; Male; Metabolic Networks and Pathways; Metabolome; Metabolomics; Mice; Osmoregulation; Purines; Reperfusion Injury; Time Factors

Topics: Advanced Oxidation Protein Products; Allopurinol; Animals; Antigens, CD34; Biomarkers; Bone Marrow; Disease Models, Animal; Hyperuricemia; Lipoproteins, HDL; Milk; Oxidative Stress; Purines; Rats; Stem Cells; Uric Acid

Topics: Animals; Biosynthetic Pathways; Brucella abortus; Brucellosis; Cell Line; Disease Models, Animal; DNA Transposable Elements; Epithelial Cells; Genetic Complementation Test; Macrophages; Mice, Inbred BALB C; Mutagenesis, Insertional; Mutation; Purines; Virulence; Virulence Factors

Topics: Animals; Body Temperature; Corpus Striatum; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; MPTP Poisoning; Paraquat; Parkinsonian Disorders; Purines; Substantia Nigra

Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alisma; Animals; Artemisia; Chromatography, High Pressure Liquid; Chromatography, Liquid; Diabetes Complications; Disease Models, Animal; Electrophoresis, Capillary; Fatty Liver; Lipid Metabolism; Liver; Male; Mass Spectrometry; Mice, Inbred C57BL; Plant Extracts; Purines

Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Movement; Cell Proliferation; CX3C Chemokine Receptor 1; Cytokines; Disease Models, Animal; Electroencephalography; Fluoresceins; Green Fluorescent Proteins; Hippocampus; In Vitro Techniques; Kainic Acid; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Organic Chemicals; Patch-Clamp Techniques; Purines; Receptors, Chemokine; Receptors, Purinergic; RNA, Messenger; Signal Transduction; Status Epilepticus; Thionucleotides; Time Factors; Up-Regulation

Topics: Adipogenesis; Animals; Disease Models, Animal; Epithelial Cells; Female; Fibrosis; Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating); Hypoxanthine; Kidney Tubules; Lipid Metabolism; Lipogenesis; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nephritis, Interstitial; Oxidative Stress; Purines; Triglycerides; Xanthine; Xanthine Dehydrogenase

Topics: Administration, Oral; Animals; Cysteine Endopeptidases; Disease Models, Animal; Humans; Mice; Nitriles; Protease Inhibitors; Purines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

Topics: Animals; Biomarkers; Choline; Choline Deficiency; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Gene Expression; Glycine Hydroxymethyltransferase; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mutation; Neural Tube Defects; Purines; Severity of Illness Index; Thymidine Monophosphate; Thymidylate Synthase; Vitamin B Complex

Topics: 5'-Nucleotidase; Adenine; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Brain; Disease Models, Animal; Extracellular Fluid; Gene Expression Regulation, Enzymologic; GPI-Linked Proteins; Hyperhomocysteinemia; Purines; Rats; Rats, Wistar; RNA, Messenger; Subcellular Fractions; Synaptosomes

Topics: Administration, Intranasal; Animals; Bacterial Proteins; Colony Count, Microbial; Disease Models, Animal; Dysentery, Bacillary; Female; HeLa Cells; Humans; Inflammation; Lung; Lung Diseases; Mice; Mice, Inbred BALB C; Mutation; Purines; Shigella flexneri; Virulence

Topics: Aldehyde Reductase; Analysis of Variance; Animals; Carbon Isotopes; Cells, Cultured; Crosses, Genetic; Cyclic AMP; Diabetes Mellitus, Type 1; Disease Models, Animal; Follicle Stimulating Hormone; Meiosis; Mice; Mice, Inbred C57BL; Oocytes; Purines; Scintillation Counting; Sorbitol; Tritium

Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Carrier Proteins; Corpus Striatum; Disease Models, Animal; Gene Expression Regulation; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Hippocampus; In Situ Hybridization; Kindling, Neurologic; Male; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Purines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptors, Purinergic P1; Seizures; Sulfur Isotopes; Tritium; Xanthines

Topics: Animals; Bacterial Proteins; Brucella abortus; Brucellosis; Cells, Cultured; Culture Media; Disease Models, Animal; DNA Transposable Elements; Humans; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mutagenesis, Insertional; Purines; Virulence

Topics: Adenosine; Affinity Labels; Animals; Astrocytes; Brain Ischemia; Cells, Cultured; Deoxyglucose; Dipyridamole; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Hypoxia; Inosine; Models, Biological; Neurons; Oligomycins; Phosphodiesterase Inhibitors; Prosencephalon; Purines; Rats; Thioinosine; Tritium

Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen Peroxide; In Vitro Techniques; Lung; Lung Diseases; Male; Oxidants; Perfusion; Propofol; Purines; Rabbits; Xanthine Oxidase

Topics: Acetic Acid; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Biomarkers; Chromatography, High Pressure Liquid; Colitis; Disease Models, Animal; Energy Metabolism; Hemoglobins; Inosine; Male; Peroxidase; Purines; Rats; Rats, Wistar; Time Factors; Uric Acid

Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Disease Models, Animal; Glutathione; Glutathione Disulfide; Liver Transplantation; Organ Preservation; Purines; Swine