purine has been researched along with Disease Models, Animal in 36 studies
1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Since 2012, studies in mice, rats, and humans have suggested that abnormalities in purinergic signaling may be a final common pathway for many genetic and environmental causes of autism spectrum disorder (ASD)." | 8.02 | Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder. ( Blake, DR; Hirsch, CM; Le, TP; Li, K; Meinardi, S; Monk, JM; Nakayama, T; Naviaux, JC; Naviaux, RK; Wang, L; Zolkipli-Cunningham, Z, 2021) |
| "Since homocysteine (Hcy) is considered a risk factor to cerebral diseases and adenine nucleotides are important molecules to brain normal function, in the present study we investigated the effect of chronic mild hyperhomocysteinemia on ectonucleotidase activities and expression in rat cerebral cortex." | 7.78 | Mild hyperhomocysteinemia alters extracellular adenine metabolism in rat brain. ( Bogo, MR; Bonan, CD; Casali, EA; Ferreira, AG; Savio, LE; Scherer, EB; Schmitz, F; Tasca, RA; Vuaden, FC; Wyse, AT, 2012) |
| "Colitis reduces the blood and tissue levels of adenosine deaminase and adenylate deaminase." | 7.71 | Blood purine and energy status in rats with colitis. ( Al-Awadi, FM; Khan, I, 2001) |
| "Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes." | 6.66 | Neonatal Seizures and Purinergic Signalling. ( Engel, T; Menéndez Méndez, A; Smith, J, 2020) |
| "Purine levels were measured by in vivo microdialysis and showed a small increase in adenosine and a dramatic increase in its metabolites after kindled seizures." | 5.32 | Changes in purine levels and adenosine receptors in kindled seizures in the rat. ( Adén, U; Berman, RF; O'Connor, WT, 2004) |
| "Since 2012, studies in mice, rats, and humans have suggested that abnormalities in purinergic signaling may be a final common pathway for many genetic and environmental causes of autism spectrum disorder (ASD)." | 4.02 | Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder. ( Blake, DR; Hirsch, CM; Le, TP; Li, K; Meinardi, S; Monk, JM; Nakayama, T; Naviaux, JC; Naviaux, RK; Wang, L; Zolkipli-Cunningham, Z, 2021) |
| " In addition, we identified specific metabolites that may contribute to early renal injury response, perturbed energy metabolism, impaired purine metabolism, impacted osmotic regulation and the induction of inflammation." | 3.80 | Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion. ( Dong, Z; Fogle, P; Wei, Q; Xiao, X, 2014) |
| "5% fat UHT milk diet or allopurinol therapy in rat experimental hyperuricemia." | 3.80 | Short communication: Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia. ( Cvetkovic, T; Jevtovic, T; Jovanovic, A; Jovanovic, J; Kocic, G; Kocic, H; Sokolovic, D; Stojanovic, S; Veljkovic, A; Zivkovic, P, 2014) |
| "Since homocysteine (Hcy) is considered a risk factor to cerebral diseases and adenine nucleotides are important molecules to brain normal function, in the present study we investigated the effect of chronic mild hyperhomocysteinemia on ectonucleotidase activities and expression in rat cerebral cortex." | 3.78 | Mild hyperhomocysteinemia alters extracellular adenine metabolism in rat brain. ( Bogo, MR; Bonan, CD; Casali, EA; Ferreira, AG; Savio, LE; Scherer, EB; Schmitz, F; Tasca, RA; Vuaden, FC; Wyse, AT, 2012) |
| "We examined whether genetic disruption of the Shmt1 gene in mice induces NTDs in response to maternal folate and choline deficiency and whether a corresponding disruption in de novo thymidylate biosynthesis underlies NTD pathogenesis." | 3.77 | Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. ( Abarinov, EV; Allen, RH; Beaudin, AE; Chu, S; Noden, DM; Perry, CA; Stabler, SP; Stover, PJ, 2011) |
| "Using a rat model of cerebral ischemia, the ENT1 inhibitor nitrobenzylmercaptopurine ribonucleoside (NBMPR) significantly increased post-ischemic forebrain adenosine levels and significantly decreased hippocampal neuron injury relative to saline-treatment." | 3.73 | Astrocytes and neurons: different roles in regulating adenosine levels. ( Parkinson, FE; Xiong, W; Zamzow, CR, 2005) |
| "Colitis reduces the blood and tissue levels of adenosine deaminase and adenylate deaminase." | 3.71 | Blood purine and energy status in rats with colitis. ( Al-Awadi, FM; Khan, I, 2001) |
| "Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes." | 2.66 | Neonatal Seizures and Purinergic Signalling. ( Engel, T; Menéndez Méndez, A; Smith, J, 2020) |
| "Gout is the typical feature of GAstrV infection in goslings." | 1.56 | Goose astrovirus infection affects uric acid production and excretion in goslings. ( Bao, E; Lv, Y; Wu, W; Xu, R, 2020) |
| "Cancer cachexia is a systemic wasting syndrome characterized by anorexia and loss of body weight." | 1.51 | A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain. ( Hisaka, A; Kurebayashi, N; Miyano, K; Nonaka, M; Sakurai, T; Sato, H; Uezono, Y; Uzu, M; Yanagihara, K, 2019) |
| "A rat myocardial ischemia-bradycardia-sudden cardiac death （MI-B-SCD） model was established, which was compared with the sham-operation group." | 1.46 | [Metabolic Characteristics of Lethal Bradycardia Induced by Myocardial Ischemia]. ( Kong, J; Wang, D; Wang, XX; Wu, JY; Yu, XJ, 2017) |
| " A lead inhibitor that had potent activity against the trypanosomal protease TbcatB in vitro and cultured parasites ex vivo was optimized by rationally driven medicinal chemistry to an inhibitor that is orally available, penetrates the CNS, has a promising pharmacokinetic profile, and is non-toxic at 200mg/kg in a repeat dosage study." | 1.36 | Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models. ( Brun, R; Guy, RK; Kaiser, M; Lemoff, A; Lu, M; Mallari, JP; Zhu, F, 2010) |
| "Purine levels were measured by in vivo microdialysis and showed a small increase in adenosine and a dramatic increase in its metabolites after kindled seizures." | 1.32 | Changes in purine levels and adenosine receptors in kindled seizures in the rat. ( Adén, U; Berman, RF; O'Connor, WT, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.78) | 18.7374 |
| 1990's | 1 (2.78) | 18.2507 |
| 2000's | 12 (33.33) | 29.6817 |
| 2010's | 14 (38.89) | 24.3611 |
| 2020's | 8 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Yasui, H | 1 |
| Iizuka, D | 1 |
| Hiraoka, W | 1 |
| Kuwabara, M | 1 |
| Matsuda, A | 1 |
| Inanami, O | 1 |
| Sun, R | 1 |
| Huang, J | 1 |
| Yang, N | 1 |
| He, J | 1 |
| Yu, X | 2 |
| Feng, S | 1 |
| Xie, Y | 1 |
| Wang, G | 1 |
| Ye, H | 1 |
| Aa, J | 1 |
| Wu, W | 1 |
| Xu, R | 1 |
| Lv, Y | 1 |
| Bao, E | 1 |
| Menéndez Méndez, A | 1 |
| Smith, J | 1 |
| Engel, T | 1 |
| Nishi, H | 1 |
| Yamanaka, D | 1 |
| Masuda, M | 1 |
| Goda, Y | 1 |
| Ito, K | 1 |
| Hakuno, F | 1 |
| Takahashi, SI | 1 |
| Bruchmann, S | 1 |
| Feltwell, T | 1 |
| Parkhill, J | 1 |
| Short, FL | 1 |
| Zolkipli-Cunningham, Z | 1 |
| Naviaux, JC | 1 |
| Nakayama, T | 1 |
| Hirsch, CM | 1 |
| Monk, JM | 1 |
| Li, K | 1 |
| Wang, L | 2 |
| Le, TP | 1 |
| Meinardi, S | 1 |
| Blake, DR | 1 |
| Naviaux, RK | 1 |
| Wang, Q | 1 |
| Guan, YF | 1 |
| Hancock, SE | 1 |
| Wahi, K | 1 |
| van Geldermalsen, M | 1 |
| Zhang, BK | 1 |
| Pang, A | 1 |
| Nagarajah, R | 1 |
| Mak, B | 1 |
| Freidman, N | 1 |
| Horvath, LG | 1 |
| Turner, N | 1 |
| Holst, J | 1 |
| Hu, Q | 1 |
| Qin, Y | 1 |
| Ji, S | 1 |
| Shi, X | 1 |
| Dai, W | 1 |
| Fan, G | 1 |
| Li, S | 1 |
| Xu, W | 1 |
| Liu, W | 1 |
| Liu, M | 1 |
| Zhang, Z | 1 |
| Ye, Z | 1 |
| Zhou, Z | 1 |
| Yang, J | 1 |
| Zhuo, Q | 1 |
| Li, M | 1 |
| Xu, X | 1 |
| Souza, CF | 1 |
| Baldissera, MD | 1 |
| Moreira, KLS | 1 |
| da Rocha, MIUM | 1 |
| da Veiga, ML | 1 |
| Santos, RCV | 1 |
| Baldisserotto, B | 1 |
| Wu, JY | 1 |
| Wang, D | 1 |
| Kong, J | 1 |
| Wang, XX | 1 |
| Yu, XJ | 1 |
| Tzoneva, G | 1 |
| Dieck, CL | 1 |
| Oshima, K | 1 |
| Ambesi-Impiombato, A | 1 |
| Sánchez-Martín, M | 1 |
| Madubata, CJ | 1 |
| Khiabanian, H | 1 |
| Yu, J | 1 |
| Waanders, E | 1 |
| Iacobucci, I | 1 |
| Sulis, ML | 1 |
| Kato, M | 1 |
| Koh, K | 1 |
| Paganin, M | 1 |
| Basso, G | 1 |
| Gastier-Foster, JM | 1 |
| Loh, ML | 1 |
| Kirschner-Schwabe, R | 1 |
| Mullighan, CG | 1 |
| Rabadan, R | 1 |
| Ferrando, AA | 1 |
| Uzu, M | 1 |
| Nonaka, M | 1 |
| Miyano, K | 1 |
| Sato, H | 1 |
| Kurebayashi, N | 1 |
| Yanagihara, K | 1 |
| Sakurai, T | 1 |
| Hisaka, A | 1 |
| Uezono, Y | 1 |
| Wang, SB | 1 |
| Jin, P | 1 |
| Li, FN | 1 |
| Quan, ZS | 1 |
| Wei, Q | 1 |
| Xiao, X | 1 |
| Fogle, P | 1 |
| Dong, Z | 1 |
| Kocic, G | 1 |
| Sokolovic, D | 1 |
| Jevtovic, T | 1 |
| Cvetkovic, T | 1 |
| Veljkovic, A | 1 |
| Kocic, H | 1 |
| Stojanovic, S | 1 |
| Jovanovic, A | 1 |
| Jovanovic, J | 1 |
| Zivkovic, P | 1 |
| Truong, QL | 1 |
| Cho, Y | 1 |
| Barate, AK | 1 |
| Kim, S | 1 |
| Watarai, M | 1 |
| Hahn, TW | 1 |
| Jiao, Y | 1 |
| Dou, Y | 1 |
| Lockwood, G | 1 |
| Pani, A | 1 |
| Jay Smeyne, R | 1 |
| Kim, Y | 1 |
| Lee, IS | 1 |
| Kim, KH | 1 |
| Park, J | 1 |
| Lee, JH | 1 |
| Bang, E | 1 |
| Jang, HJ | 1 |
| Na, YC | 1 |
| Avignone, E | 1 |
| Ulmann, L | 1 |
| Levavasseur, F | 1 |
| Rassendren, F | 1 |
| Audinat, E | 1 |
| Ohtsubo, T | 1 |
| Matsumura, K | 1 |
| Sakagami, K | 1 |
| Fujii, K | 1 |
| Tsuruya, K | 1 |
| Noguchi, H | 1 |
| Rovira, II | 1 |
| Finkel, T | 1 |
| Iida, M | 1 |
| Mallari, JP | 1 |
| Zhu, F | 1 |
| Lemoff, A | 1 |
| Kaiser, M | 1 |
| Lu, M | 1 |
| Brun, R | 1 |
| Guy, RK | 1 |
| Beaudin, AE | 1 |
| Abarinov, EV | 1 |
| Noden, DM | 1 |
| Perry, CA | 1 |
| Chu, S | 1 |
| Stabler, SP | 1 |
| Allen, RH | 1 |
| Stover, PJ | 1 |
| Scherer, EB | 1 |
| Schmitz, F | 1 |
| Vuaden, FC | 1 |
| Savio, LE | 1 |
| Ferreira, AG | 1 |
| Tasca, RA | 1 |
| Casali, EA | 1 |
| Bogo, MR | 1 |
| Bonan, CD | 1 |
| Wyse, AT | 1 |
| Morisaki, T | 1 |
| Cersini, A | 1 |
| Martino, MC | 1 |
| Martini, I | 1 |
| Rossi, G | 1 |
| Bernardini, ML | 1 |
| Colton, SA | 1 |
| Downs, SM | 1 |
| Adén, U | 1 |
| O'Connor, WT | 1 |
| Berman, RF | 1 |
| Alcantara, RB | 1 |
| Read, RD | 1 |
| Valderas, MW | 1 |
| Brown, TD | 1 |
| Roop, RM | 1 |
| Gao, ZQ | 1 |
| Deng, YY | 1 |
| Chen, YP | 1 |
| Parkinson, FE | 1 |
| Xiong, W | 1 |
| Zamzow, CR | 1 |
| Yumoto, M | 1 |
| Nishida, O | 1 |
| Nakamura, F | 1 |
| Katsuya, H | 1 |
| Allison, AC | 1 |
| Eugui, EM | 1 |
| Al-Awadi, FM | 1 |
| Khan, I | 1 |
| Marinello, E | 1 |
| Tabucchi, A | 1 |
| Rosi, F | 1 |
| Gerunda, G | 1 |
| Merenda, R | 1 |
| Ballarin, R | 1 |
| Neri, D | 1 |
| Carlucci, F | 1 |
| Chanarin, I | 1 |
| Deacon, R | 1 |
| Lumb, M | 1 |
| Muir, M | 1 |
| Perry, J | 1 |
6 reviews available for purine and Disease Models, Animal
| Article | Year |
|---|---|
Nucleoside analogs as a radiosensitizer modulating DNA repair, cell cycle checkpoints, and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Disease Models, | 2020 |
Neonatal Seizures and Purinergic Signalling.
Topics: Animals; Central Nervous System; Disease Models, Animal; Humans; Hypothermia, Induced; Infant; Infan | 2020 |
[Animal models for abnormal purine metabolism].
Topics: Adenine Phosphoribosyltransferase; Adenosine Deaminase; AMP Deaminase; Animals; Disease Models, Anim | 2003 |
[Researches on the establishment of chronic nephropathy models and the effect of TCM on these models].
Topics: Animals; Disease Models, Animal; Drugs, Chinese Herbal; Hyperuricemia; Kidney Diseases; Mice; Phytot | 2005 |
Purine metabolism and immunosuppressive effects of mycophenolate mofetil (MMF).
Topics: Animals; B-Lymphocytes; Disease Models, Animal; DNA; Enzyme Inhibitors; Graft Rejection; Graft vs Ho | 1996 |
Cobalamin-folate interrelations: a critical review.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Anemia, Megaloblastic; Animals; Central N | 1985 |
30 other studies available for purine and Disease Models, Animal
| Article | Year |
|---|---|
Purine Catabolism Shows a Dampened Circadian Rhythmicity in a High-fat Diet-Induced Mouse Model of Obesity.
Topics: Animals; Biomarkers; Circadian Rhythm; Diet, High-Fat; Disease Models, Animal; Metabolome; Metabolom | 2019 |
Goose astrovirus infection affects uric acid production and excretion in goslings.
Topics: Animals; Astroviridae Infections; Avastrovirus; Avian Proteins; Carrier Proteins; Disease Models, An | 2020 |
Alteration of serum amino acid profiles by dietary adenine supplementation inhibits fatty liver development in rats.
Topics: Adenine; Amino Acids; Animals; Dietary Supplements; Disease Models, Animal; Disease Susceptibility; | 2020 |
Identifying virulence determinants of multidrug-resistant Klebsiella pneumoniae in Galleria mellonella.
Topics: Animals; Bacterial Proteins; Disease Models, Animal; DNA, Bacterial; Drug Resistance, Multiple, Bact | 2021 |
Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder.
Topics: Acute Disease; Adenosine Triphosphate; Animals; Autism Spectrum Disorder; Behavior, Animal; Body Tem | 2021 |
Inhibition of guanosine monophosphate synthetase (GMPS) blocks glutamine metabolism and prostate cancer growth.
Topics: Animals; Carbon-Nitrogen Ligases; Cell Line, Tumor; Cell Proliferation; Cohort Studies; Computationa | 2021 |
MTAP Deficiency-Induced Metabolic Reprogramming Creates a Vulnerability to Cotargeting
Topics: Animals; Biomarkers, Tumor; Cell Line, Tumor; Cell Survival; Cellular Reprogramming; Computational B | 2021 |
Involvement of xanthine oxidase activity with oxidative and inflammatory renal damage in silver catfish experimentally infected with Streptococcus agalactiae: Interplay with reactive oxygen species and nitric oxide.
Topics: Animals; Brazil; Catfishes; Disease Models, Animal; Fisheries; Fresh Water; Kidney; Kidney Tubules; | 2017 |
[Metabolic Characteristics of Lethal Bradycardia Induced by Myocardial Ischemia].
Topics: Animals; Bradycardia; Coronary Artery Disease; Death, Sudden, Cardiac; Disease Models, Animal; Gas C | 2017 |
Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia.
Topics: 5'-Nucleotidase; Animals; Cell Proliferation; Clonal Evolution; Disease Models, Animal; Drug Resista | 2018 |
A novel strategy for treatment of cancer cachexia targeting xanthine oxidase in the brain.
Topics: Administration, Oral; Animals; Brain; Cachexia; Disease Models, Animal; Febuxostat; Male; Mice, Inbr | 2019 |
Synthesis and anticonvulsant activity of novel purine derivatives.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Mice; Motor Activity; Pentylenetetra | 2014 |
Changes in metabolic profiles during acute kidney injury and recovery following ischemia/reperfusion.
Topics: Acute Kidney Injury; Animals; Cluster Analysis; Disease Models, Animal; Energy Metabolism; Glucose; | 2014 |
Short communication: Effect of commercial or depurinized milk diet on plasma advanced oxidation protein products, cardiovascular markers, and bone marrow CD34+ stem cell potential in rat experimental hyperuricemia.
Topics: Advanced Oxidation Protein Products; Allopurinol; Animals; Antigens, CD34; Biomarkers; Bone Marrow; | 2014 |
Mutation of purD and purF genes further attenuates Brucella abortus strain RB51.
Topics: Animals; Biosynthetic Pathways; Brucella abortus; Brucellosis; Cell Line; Disease Models, Animal; DN | 2015 |
Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL/6J Mice.
Topics: Animals; Body Temperature; Corpus Striatum; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; | 2015 |
Metabolic Profiling of Liver Tissue in Diabetic Mice Treated with Artemisia Capillaris and Alisma Rhizome Using LC-MS and CE-MS.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Alisma; Animals; Artemisia; Chromatography, High Pr | 2016 |
Status epilepticus induces a particular microglial activation state characterized by enhanced purinergic signaling.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cell Movement; Cell Proliferation; CX3C Chem | 2008 |
Xanthine oxidoreductase depletion induces renal interstitial fibrosis through aberrant lipid and purine accumulation in renal tubules.
Topics: Adipogenesis; Animals; Disease Models, Animal; Epithelial Cells; Female; Fibrosis; Glyceraldehyde-3- | 2009 |
Optimization of purine-nitrile TbcatB inhibitors for use in vivo and evaluation of efficacy in murine models.
Topics: Administration, Oral; Animals; Cysteine Endopeptidases; Disease Models, Animal; Humans; Mice; Nitril | 2010 |
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice.
Topics: Animals; Biomarkers; Choline; Choline Deficiency; Disease Models, Animal; Folic Acid; Folic Acid Def | 2011 |
Mild hyperhomocysteinemia alters extracellular adenine metabolism in rat brain.
Topics: 5'-Nucleotidase; Adenine; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; | 2012 |
Analysis of virulence and inflammatory potential of Shigella flexneri purine biosynthesis mutants.
Topics: Administration, Intranasal; Animals; Bacterial Proteins; Colony Count, Microbial; Disease Models, An | 2003 |
Potential role for the sorbitol pathway in the meiotic dysfunction exhibited by oocytes from diabetic mice.
Topics: Aldehyde Reductase; Analysis of Variance; Animals; Carbon Isotopes; Cells, Cultured; Crosses, Geneti | 2004 |
Changes in purine levels and adenosine receptors in kindled seizures in the rat.
Topics: Animals; Autoradiography; Binding Sites; Brain Chemistry; Carrier Proteins; Corpus Striatum; Disease | 2004 |
Intact purine biosynthesis pathways are required for wild-type virulence of Brucella abortus 2308 in the BALB/c mouse model.
Topics: Animals; Bacterial Proteins; Brucella abortus; Brucellosis; Cells, Cultured; Culture Media; Disease | 2004 |
Astrocytes and neurons: different roles in regulating adenosine levels.
Topics: Adenosine; Affinity Labels; Animals; Astrocytes; Brain Ischemia; Cells, Cultured; Deoxyglucose; Dipy | 2005 |
Propofol attenuates oxidant-induced acute lung injury in an isolated perfused rabbit-lung model.
Topics: Animals; Antioxidants; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrogen | 2005 |
Blood purine and energy status in rats with colitis.
Topics: Acetic Acid; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Anim | 2001 |
Organ preservation during experimental liver transplantation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Disease Models, Animal; Glutathione; Glutath | 2000 |