purine has been researched along with Autoimmune Diseases in 4 studies
1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.
Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine." | 7.73 | [Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout]. ( Anan'eva, MN; Dubiaga, VV; Nikolenko, IuI; Nikolenko, VIu; Shchukin, IN; Siniachenko, OV, 2005) |
| " Methotrexate (MTX), a first-line rheumatoid arthritis (RA) treatment, inhibits mammalian dihydrofolate reductase (DHFR), but whether it directly impacts gut bacteria is unclear." | 4.02 | Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation. ( Alexander, M; Deshpande, I; Nayak, RR; Patterson, AD; Rimal, B; Scher, JU; Stapleton-Gray, K; Turnbaugh, PJ; Ubeda, C, 2021) |
| "Patients with system lupus erythematosus, rheumatic arthritis, chronic active hepatitis and gout were found to have considerable hyperuricemia and be decreased in aminoacides content, which are the predecessors of purine." | 3.73 | [Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout]. ( Anan'eva, MN; Dubiaga, VV; Nikolenko, IuI; Nikolenko, VIu; Shchukin, IN; Siniachenko, OV, 2005) |
| "Cladribine was synthesized as a purine analogue drug that inhibited adenosine deaminase." | 2.45 | Cladribine: not just another purine analogue? ( Epner, EM; Phillips, JD; Spurgeon, S; Yu, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nayak, RR | 1 |
| Alexander, M | 1 |
| Deshpande, I | 1 |
| Stapleton-Gray, K | 1 |
| Rimal, B | 1 |
| Patterson, AD | 1 |
| Ubeda, C | 1 |
| Scher, JU | 1 |
| Turnbaugh, PJ | 1 |
| Spurgeon, S | 1 |
| Yu, M | 1 |
| Phillips, JD | 1 |
| Epner, EM | 1 |
| Nikolenko, IuI | 1 |
| Siniachenko, OV | 1 |
| Anan'eva, MN | 1 |
| Nikolenko, VIu | 1 |
| Dubiaga, VV | 1 |
| Shchukin, IN | 1 |
| Chanaud, NP | 1 |
| Vistica, BP | 1 |
| Eugui, E | 1 |
| Nussenblatt, RB | 1 |
| Allison, AC | 1 |
| Gery, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Myfortic (Enteric-coated Mycophenolate Sodium) for the Treatment of Non-infectious Intermediate Uveitis - a Prospective, Controlled, Randomized Multicenter Trial[NCT01092533] | Phase 3 | 44 participants (Actual) | Interventional | 2010-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for purine and Autoimmune Diseases
| Article | Year |
|---|---|
Cladribine: not just another purine analogue?
Topics: Adenosine Deaminase Inhibitors; Antineoplastic Agents; Autoimmune Diseases; Cladribine; Clinical Tri | 2009 |
3 other studies available for purine and Autoimmune Diseases
| Article | Year |
|---|---|
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Bacteria; Female; Gastrointestinal Microbiome; | 2021 |
[Hyperuricemia and disorders in content of amino acids-purine precursors in patients with autoimmune diseases and gout].
Topics: Amino Acids; Autoimmune Diseases; Gout; Humans; Hyperuricemia; Lipid Peroxides; Purines; Uric Acid; | 2005 |
Inhibition of experimental autoimmune uveoretinitis by mycophenolate mofetil, an inhibitor of purine metabolism.
Topics: Animals; Autoantibodies; Autoimmune Diseases; Female; Immunosuppressive Agents; Lymphocyte Activatio | 1995 |