purine has been researched along with Arthritis, Rheumatoid in 5 studies
1H-purine : The 1H-tautomer of purine.
3H-purine : The 3H-tautomer of purine.
9H-purine : The 9H-tautomer of purine.
7H-purine : The 7H-tautomer of purine.
Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5-aminoimidazole-4-carboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation." | 9.11 | The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. ( Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA, 2004) |
| "Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been attributed to clinical heterogeneity and genetic variations influencing MTX pharmacology." | 7.75 | Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians. ( Aneja, R; Arya, V; Das, M; Dhir, V; Grover, R; Gupta, R; Juyal, RC; K, TB; Kumar, A; Kumar, U; Marwaha, V; Raghu, P; Shankar, S; Sharma, S; Singh, P, 2009) |
| "To study the possible association of purine enzyme activities with response to azathioprine (AZA) treatment in rheumatoid arthritis (RA) and their correlation with parameters of disease activity." | 7.69 | Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine. A pilot study. ( Boerbooms, AM; De Abreu, RA; de Graaf, R; Kerstens, PJ; Lambooy, LH; Stolk, JN; van de Putte, LB, 1994) |
| "To determine if folinic acid supplementation during methotrexate (MTX) therapy for rheumatoid arthritis (RA) reduces both urinary 5-aminoimidazole-4-carboxamide (AICA) and urinary adenosine excretion more than does folic acid supplementation." | 5.11 | The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. ( Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA, 2004) |
| " Methotrexate (MTX), a first-line rheumatoid arthritis (RA) treatment, inhibits mammalian dihydrofolate reductase (DHFR), but whether it directly impacts gut bacteria is unclear." | 4.02 | Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation. ( Alexander, M; Deshpande, I; Nayak, RR; Patterson, AD; Rimal, B; Scher, JU; Stapleton-Gray, K; Turnbaugh, PJ; Ubeda, C, 2021) |
| "Inter-individual variations to methotrexate (MTX) response among rheumatoid arthritis (RA) patients have been attributed to clinical heterogeneity and genetic variations influencing MTX pharmacology." | 3.75 | Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians. ( Aneja, R; Arya, V; Das, M; Dhir, V; Grover, R; Gupta, R; Juyal, RC; K, TB; Kumar, A; Kumar, U; Marwaha, V; Raghu, P; Shankar, S; Sharma, S; Singh, P, 2009) |
| "To study the possible association of purine enzyme activities with response to azathioprine (AZA) treatment in rheumatoid arthritis (RA) and their correlation with parameters of disease activity." | 3.69 | Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine. A pilot study. ( Boerbooms, AM; De Abreu, RA; de Graaf, R; Kerstens, PJ; Lambooy, LH; Stolk, JN; van de Putte, LB, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nayak, RR | 1 |
| Alexander, M | 1 |
| Deshpande, I | 1 |
| Stapleton-Gray, K | 1 |
| Rimal, B | 1 |
| Patterson, AD | 1 |
| Ubeda, C | 1 |
| Scher, JU | 1 |
| Turnbaugh, PJ | 1 |
| Sharma, S | 1 |
| Das, M | 1 |
| Kumar, A | 1 |
| Marwaha, V | 1 |
| Shankar, S | 1 |
| Singh, P | 1 |
| Raghu, P | 1 |
| Aneja, R | 1 |
| Grover, R | 1 |
| Arya, V | 1 |
| Dhir, V | 1 |
| Gupta, R | 1 |
| Kumar, U | 1 |
| Juyal, RC | 1 |
| K, TB | 1 |
| Morgan, SL | 1 |
| Oster, RA | 1 |
| Lee, JY | 1 |
| Alarcón, GS | 1 |
| Baggott, JE | 1 |
| Kondo, H | 1 |
| Iizuka, N | 1 |
| Kerstens, PJ | 1 |
| Stolk, JN | 1 |
| Boerbooms, AM | 1 |
| Lambooy, LH | 1 |
| de Graaf, R | 1 |
| De Abreu, RA | 1 |
| van de Putte, LB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Mechanisms of Antifolate Efficacy in Arthritis[NCT00000395] | Phase 2 | 40 participants (Actual) | Interventional | 1996-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for purine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
[Mizoribine].
Topics: Animals; Arthritis, Rheumatoid; Depression, Chemical; Guanosine Monophosphate; Humans; Immunosuppres | 2005 |
1 trial available for purine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homo | 2004 |
3 other studies available for purine and Arthritis, Rheumatoid
| Article | Year |
|---|---|
Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.
Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Bacteria; Female; Gastrointestinal Microbiome; | 2021 |
Purine biosynthetic pathway genes and methotrexate response in rheumatoid arthritis patients among north Indians.
Topics: AMP Deaminase; Arthritis, Rheumatoid; Female; Genetic Variation; Humans; Hydroxymethyl and Formyl Tr | 2009 |
Purine enzymes in rheumatoid arthritis: possible association with response to azathioprine. A pilot study.
Topics: 5'-Nucleotidase; Adenine Phosphoribosyltransferase; Adult; Aged; Arthritis, Rheumatoid; Azathioprine | 1994 |