punicalagin and Hepatitis

Punicalagin (PU)-rich pomegranate peel extract has been shown before to exert protective effects against high fat-induced hepatic damage. The aim of this study is to explore whether and how PU antagonizes hepatic steatosis in Western diet-fed (WD) mice.. The findings suggest that PU improves hepatic steatosis induced by WD, in part through regulating lipid homeostasis and inflammation in liver and adipose tissue and restoring microbiota shift and impaired gut barrier function. Thus, PU can be potentially developed as a potential prevention strategy in combating nonalcoholic fatty liver disease.

Topics: Adiponectin; Animals; Diet, Western; Dysbiosis; Gastrointestinal Microbiome; Hepatitis; Hydrolyzable Tannins; Insulin Resistance; Intra-Abdominal Fat; Lipid Metabolism; Lipid Peroxidation; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Panniculitis