pumiliotoxin-a and Seizures

pumiliotoxin-a has been researched along with Seizures* in 1 studies

Other Studies

1 other study(ies) available for pumiliotoxin-a and Seizures

Article	Year
Total synthesis and Natural product research, 2021, Volume: 35, Issue:3 The total synthesis of both the double bond isomers of indolizine alkaloid 8-deoxypumiliotoxin 193H has been accomplished. Both the double bond isomers Z-4 and E-4 induced convulsions and inhibited neuro-muscular activity at a dose of 25 mg/kg after intraperitoneal injection in mice. The lethal dose of Z-4 and E-4 was 100 mg/kg, indicating that 8-deoxypumiliotoxin 193H is 10-times less toxic than the known pumiliotoxin (+)-251 D. Topics: Alkaloids; Animals; Body Temperature; Dose-Response Relationship, Drug; Indolizines; Injections, Intraperitoneal; Isomerism; Male; Mice, Inbred Strains; Muscle Strength; Piperidines; Rotarod Performance Test; Seizures; Structure-Activity Relationship	2021

Article

Year

Natural product research, 2021, Volume: 35, Issue:3

The total synthesis of both the double bond isomers of indolizine alkaloid 8-deoxypumiliotoxin 193H has been accomplished. Both the double bond isomers Z-4 and E-4 induced convulsions and inhibited neuro-muscular activity at a dose of 25 mg/kg after intraperitoneal injection in mice. The lethal dose of Z-4 and E-4 was 100 mg/kg, indicating that 8-deoxypumiliotoxin 193H is 10-times less toxic than the known pumiliotoxin (+)-251 D.

Topics: Alkaloids; Animals; Body Temperature; Dose-Response Relationship, Drug; Indolizines; Injections, Intraperitoneal; Isomerism; Male; Mice, Inbred Strains; Muscle Strength; Piperidines; Rotarod Performance Test; Seizures; Structure-Activity Relationship

2021