pulmicort and Dermatitis--Irritant

Topics: Acute Disease; Administration, Topical; Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents; Body Water; Budesonide; Dermatitis, Irritant; Drug Administration Schedule; Humans; Linoleic Acid; Linoleic Acids; Methylprednisolone; Pregnenediones; Skin

Allergic contact dermatitis is the most common adverse reaction caused by topical drugs.. To study the demographic characteristics and lesion locations of patients with iatrogenic dermatitis, and to analyse contact allergy to active principles and trends in frequencies over the years.. Between 1990 and 2014, 14 911 patients were patch tested with the European baseline series. Patients with a presumed iatrogenic cause were often tested with a pharmaceutical series, and, if indicated, with photo-patch tests. Most were also tested with the topical products to which they had been exposed, along with their ingredients.. Eight thousand three hundred and seventy-four (56%) patients tested positively, and 2600 (17.4%, 95%CI: 16.8-18.0%) of all patients suffered from iatrogenic contact dermatitis. The most important primary sites of dermatitis were the legs, face, and hands. The most common sensitizers included topical antibiotics, antiseptics, and corticosteroids. The most frequent baseline allergens in this subgroup were budesonide, neomycin, and benzocaine, although with a decreasing trend over the years. Many other allergens from different pharmacological classes were identified.. With a prevalence of 17.4% of consecutive patients, iatrogenic contact dermatitis is a frequent diagnosis in patients attending a general patch test clinic, involving one-third of the patients with at least one positive reaction.

Topics: Administration, Cutaneous; Administration, Topical; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Anesthetics, Local; Anti-Bacterial Agents; Anti-Infective Agents, Local; Belgium; Benzocaine; Budesonide; Child; Child, Preschool; Dermatitis, Allergic Contact; Dermatitis, Irritant; Facial Dermatoses; Female; Glucocorticoids; Hand Dermatoses; Humans; Iatrogenic Disease; Infant; Infant, Newborn; Leg Dermatoses; Male; Middle Aged; Neomycin; Patch Tests; Prevalence; Retrospective Studies; Young Adult

In order to map the frequency of contact hypersensitivity (CH) to epoxy resin, methyldibromoglutaronitrile (MDBGN), tixocortol pivalate (TP) and budesonide patch tests were carried out.. The tests were performed in 1448 patients. Most patients belong to the allergic and irritative contact dermatitis groups. The tests were administered with the allergens epoxy resin 1%, MDBGN 0.3%, TP 1% and budesonide 0.1%, applied on the back. Reactions were evaluated at 40 min, on day 2 (D2), day 3 (D3) and day 4 (D4). In the patients of the Dept. of Dermatology, Venerology and Dermatooncology of Semmelweis University (patients number =1073) reactions were evaluated on day 7 as well.. Epoxy resin elicited immediate reactions in 1 patient at 40 min. Further evaluations showed no difference on D3, D4 and D7 with a frequency of CH of 1.03%. Patch testing for MDBGN did not provoke immediate reactions, evaluations showed an increasing hypersensitivity rate (D2: 0.93%; D7:1.77%). Patch tests with TP yielded no immediate reactions, the frequency of CH increased from 0.47% (D2) to 2.01% (D7). No immediate reactions were observed by budesonide; an increase was seen in frequency of CH (D2:0.93% to D7:3.84%). CH to the studied allergens was observed mostly in allergic contact dermatitis group, to budesonide in irritative contact dermatitis and in atopic dermatitis groups as well.. The data of the present study are the first results about this four allergens in Hungary and to our knowledge from our region as well.

Topics: Allergens; Budesonide; Dermatitis, Allergic Contact; Dermatitis, Contact; Dermatitis, Irritant; Epoxy Resins; Humans; Hungary; Hydrocortisone; Hypersensitivity, Immediate; Nitriles; Patch Tests; Preservatives, Pharmaceutical; Urticaria