pteridines has been researched along with Pancreatic Neoplasms in 7 studies
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "BI 2536, a novel Polo-like kinase 1 inhibitor, was assessed in patients with unresectable advanced exocrine adenocarcinoma of the pancreas." | 9.16 | A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas - a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network. ( Aulitzky, WE; Dittrich, C; Fleischer, F; Hollerbach, S; Merger, M; Mross, K; Munzert, G; Scheulen, ME; Schmid, RM; Schutte, J; Strumberg, D, 2012) |
| "Transforming growth factor beta (TGFbeta) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and immune suppression." | 5.34 | Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness. ( Chakravarty, S; Damm, DL; Gaspar, NJ; Henson, M; Higgins, LS; Kapoun, AM; Li, G; Li, L; Medicherla, S; Muiru, GT; Murphy, A; O'Young, G; Quon, D; Reddy, M; Wong, DH, 2007) |
| "BI 2536, a novel Polo-like kinase 1 inhibitor, was assessed in patients with unresectable advanced exocrine adenocarcinoma of the pancreas." | 5.16 | A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas - a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network. ( Aulitzky, WE; Dittrich, C; Fleischer, F; Hollerbach, S; Merger, M; Mross, K; Munzert, G; Scheulen, ME; Schmid, RM; Schutte, J; Strumberg, D, 2012) |
| "Finally, pancreatic cancer cells expressing Plk1-unphosphorylatable mutants of Orc2 or Hbo1 are more sensitive to gemcitabine than cells expressing wild-type Orc2 or Hbo1." | 1.39 | Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer. ( Chiorean, EG; Elzey, BD; Hazbun, T; Konieczny, SF; Kuang, S; Liu, X; Liu, XS; Ratliff, TL; Rice, SJ; Song, B, 2013) |
| "Transforming growth factor beta (TGFbeta) is a pleiotropic factor that regulates cell proliferation, angiogenesis, metastasis, and immune suppression." | 1.34 | Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness. ( Chakravarty, S; Damm, DL; Gaspar, NJ; Henson, M; Higgins, LS; Kapoun, AM; Li, G; Li, L; Medicherla, S; Muiru, GT; Murphy, A; O'Young, G; Quon, D; Reddy, M; Wong, DH, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xin, X | 1 |
| Lin, F | 1 |
| Wang, Q | 1 |
| Yin, L | 1 |
| Mahato, RI | 1 |
| Kaneda, MM | 1 |
| Cappello, P | 1 |
| Nguyen, AV | 1 |
| Ralainirina, N | 1 |
| Hardamon, CR | 1 |
| Foubert, P | 1 |
| Schmid, MC | 1 |
| Sun, P | 1 |
| Mose, E | 1 |
| Bouvet, M | 1 |
| Lowy, AM | 1 |
| Valasek, MA | 1 |
| Sasik, R | 1 |
| Novelli, F | 1 |
| Hirsch, E | 1 |
| Varner, JA | 1 |
| Mross, K | 1 |
| Dittrich, C | 1 |
| Aulitzky, WE | 1 |
| Strumberg, D | 1 |
| Schutte, J | 1 |
| Schmid, RM | 1 |
| Hollerbach, S | 1 |
| Merger, M | 1 |
| Munzert, G | 1 |
| Fleischer, F | 1 |
| Scheulen, ME | 1 |
| Song, B | 1 |
| Liu, XS | 1 |
| Rice, SJ | 1 |
| Kuang, S | 1 |
| Elzey, BD | 1 |
| Konieczny, SF | 1 |
| Ratliff, TL | 1 |
| Hazbun, T | 1 |
| Chiorean, EG | 1 |
| Liu, X | 1 |
| Yamada, H | 1 |
| Arai, T | 1 |
| Endo, N | 1 |
| Yamashita, K | 1 |
| Nonogawa, M | 1 |
| Makino, K | 1 |
| Fukuda, K | 1 |
| Sasada, M | 1 |
| Uchiyama, T | 1 |
| Gaspar, NJ | 1 |
| Li, L | 1 |
| Kapoun, AM | 1 |
| Medicherla, S | 1 |
| Reddy, M | 1 |
| Li, G | 1 |
| O'Young, G | 1 |
| Quon, D | 1 |
| Henson, M | 1 |
| Damm, DL | 1 |
| Muiru, GT | 1 |
| Murphy, A | 1 |
| Higgins, LS | 1 |
| Chakravarty, S | 1 |
| Wong, DH | 1 |
| Stickings, P | 1 |
| Cunningham, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma[NCT03795610] | Phase 2 | 15 participants (Anticipated) | Interventional | 2020-03-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for pteridines and Pancreatic Neoplasms
| Article | Year |
|---|---|
A randomised phase II trial of the Polo-like kinase inhibitor BI 2536 in chemo-naïve patients with unresectable exocrine adenocarcinoma of the pancreas - a study within the Central European Society Anticancer Drug Research (CESAR) collaborative network.
Topics: Adenocarcinoma; Aged; Cell Cycle Proteins; Cohort Studies; Confidence Intervals; Disease-Free Surviv | 2012 |
6 other studies available for pteridines and Pancreatic Neoplasms
| Article | Year |
|---|---|
ROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer.
Topics: Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Delayed-Action Preparations; Humans; Micelles; Mic | 2019 |
Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.
Topics: Animals; Antineoplastic Agents; Biomarkers; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mov | 2016 |
Plk1 phosphorylation of orc2 and hbo1 contributes to gemcitabine resistance in pancreatic cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Cycle Proteins; Cell Li | 2013 |
Photodynamic effects of a novel pterin derivative on a pancreatic cancer cell line.
Topics: Cell Line, Tumor; Electron Spin Resonance Spectroscopy; Humans; Microscopy, Confocal; Pancreatic Neo | 2005 |
Inhibition of transforming growth factor beta signaling reduces pancreatic adenocarcinoma growth and invasiveness.
Topics: Activin Receptors, Type I; Adenocarcinoma; Animals; Cell Line, Tumor; Cell Proliferation; Genes, myc | 2007 |
Interleukin-1beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of langerhans is dependent upon the nitric oxide synthase cofactor tetrahidrobiopterin.
Topics: Animals; Biopterins; Cell Fusion; Glucose; Hypoxanthines; Insulin; Insulin Secretion; Insulinoma; In | 2002 |