Page last updated: 2024-10-20

pteridines and Ovarian Neoplasms

pteridines has been researched along with Ovarian Neoplasms in 9 studies

Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Research Excerpts

ExcerptRelevanceReference
"BI 2536 is a selective and potent small-molecule inhibitor of polo-like kinase 1."6.75Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research ( Aerts, C; Allgeier, A; Blay, JY; Bogaerts, J; Brain, E; De Greve, J; Fontaine, C; Fritsch, H; Hanft, G; Lacombe, D; Machiels, JP; Munzert, G; Rapion, J; Ray-Coquard, I; Schöffski, P; Sleijfer, S; Soria, JC; Wolter, P, 2010)
"Volasertib is a potent and selective cell-cycle kinase inhibitor that induces mitotic arrest and apoptosis by targeting Polo-like kinase."2.82Volasertib Versus Chemotherapy in Platinum-Resistant or -Refractory Ovarian Cancer: A Randomized Phase II Groupe des Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire Study. ( Del Campo, JM; Follana, P; Freyer, G; Garin-Chesa, P; Gladieff, L; Joly, F; Lesoin, A; Lortholary, A; Marzin, K; Nazabadioko, S; Pardo, B; Pilz, K; Pujade-Lauraine, E; Ray-Coquard, IL; Sassi, M; Selle, F; Sufliarsky, J; Tholander, B; Vergote, I; Vidal, L; Weber, B, 2016)
"BI 2536 is a selective and potent small-molecule inhibitor of polo-like kinase 1."2.75Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research ( Aerts, C; Allgeier, A; Blay, JY; Bogaerts, J; Brain, E; De Greve, J; Fontaine, C; Fritsch, H; Hanft, G; Lacombe, D; Machiels, JP; Munzert, G; Rapion, J; Ray-Coquard, I; Schöffski, P; Sleijfer, S; Soria, JC; Wolter, P, 2010)
"Ovarian cancer is responsible for the highest mortality among all gynecologic malignancies, and novel therapies are urgently needed to improve patient outcome."1.43BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1. ( Cai, MC; Di, W; Gao, WQ; Gu, Z; Ji, ZL; Jing, Y; Ma, P; Peng, H; Yan, Y; Zhang, M; Zhang, S; Zhang, Z; Zhuang, G, 2016)
"Early diagnostics of ovarian cancer is difficult, because there are no symptoms until the disease has progressed to an advanced stage."1.39Fluorescence characteristics of human urine from normal individuals and ovarian cancer patients. ( Hunakova, L; Lajdova, I; Martinicky, D; Sikurova, L; Zvarik, M, 2013)
"Nine patients with ovarian cancer (stages IIb-IV) were followed for a period of 16 months to date."1.27Significance of urinary neopterine in gynecological oncology: follow-up of patients with ovarian cancer. ( Bichler, A; Fuchs, D; Hausen, A; Hetzel, H; Reibnegger, G; Wachter, H, 1983)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (55.56)24.3611
2020's3 (33.33)2.80

Authors

AuthorsStudies
Pautier, P1
Motte-Rouge, T1
Lécuru, F1
Classe, JM1
Ferron, G1
Floquet, A1
Kurtz, JE1
Freyer, G2
Hardy-Bessard, AC1
Wang, Z1
Zhao, S1
Gu, W1
Dong, Y1
Meng, F1
Yuan, J1
Zhong, Z1
Díaz-Carballo, D1
Saka, S1
Acikelli, AH1
Homp, E1
Erwes, J1
Demmig, R1
Klein, J1
Schröer, K1
Malak, S1
D'Souza, F1
Noa-Bolaño, A1
Menze, S1
Pano, E1
Andrioff, S1
Teipel, M1
Dammann, P1
Klein, D1
Nasreen, A1
Tannapfel, A1
Grandi, N1
Tramontano, E1
Ochsenfarth, C1
Strumberg, D1
Zvarik, M2
Martinicky, D2
Hunakova, L2
Lajdova, I1
Sikurova, L2
Pujade-Lauraine, E1
Selle, F1
Weber, B1
Ray-Coquard, IL1
Vergote, I1
Sufliarsky, J1
Del Campo, JM1
Lortholary, A1
Lesoin, A1
Follana, P1
Pardo, B1
Vidal, L1
Tholander, B1
Gladieff, L1
Sassi, M1
Garin-Chesa, P1
Nazabadioko, S1
Marzin, K1
Pilz, K1
Joly, F1
Zhang, Z1
Ma, P1
Jing, Y1
Yan, Y1
Cai, MC1
Zhang, M1
Zhang, S1
Peng, H1
Ji, ZL1
Di, W1
Gu, Z1
Gao, WQ1
Zhuang, G1
Schöffski, P1
Blay, JY1
De Greve, J1
Brain, E1
Machiels, JP1
Soria, JC1
Sleijfer, S1
Wolter, P1
Ray-Coquard, I1
Fontaine, C1
Munzert, G1
Fritsch, H1
Hanft, G1
Aerts, C1
Rapion, J1
Allgeier, A1
Bogaerts, J1
Lacombe, D1
Hetzel, H1
Bichler, A1
Fuchs, D1
Hausen, A1
Reibnegger, G1
Wachter, H1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Randomized Trial of the Polo-like Kinase 1 Inhibitor BI 6727 Monotherapy Versus Investigator´s Choice Chemotherapy in Ovarian Cancer Patients Resistant or Refractory to Platinum-based Cytotoxic Therapy[NCT01121406]Phase 2110 participants (Actual)Interventional2010-04-30Completed
Multicenter Parallel Phase II Trial of BI 2536 Administered as One Hour IV Infusion Every 3 Weeks in Defined Cohorts of Patients With Various Solid Tumors. A New Drug Screening Program of the EORTC Network of Core Institutions (NOCI)[NCT00526149]Phase 276 participants (Actual)Interventional2007-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

AUC (0-24); Area Under the Concentration-time Curve in Plasma Over the Time Interval From 0 to 24 Hours for BI 6727 BS

AUC (0-24); area under the concentration-time curve in plasma over the time interval from 0 to 24 hours for BI 6727 BS (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionng*h/mL (Geometric Mean)
Volasertib2140

AUC (0-24); Area Under the Concentration-time Curve in Plasma Over the Time Interval From 0 to 24 Hours for CD 10899 BS

AUC (0-24); area under the concentration-time curve in plasma over the time interval from 0 to 24 hours for CD 10899 BS (metabolite of Volasertib BI 6727) (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionng*h/mL (Geometric Mean)
Volasertib204

AUC (0-inf); Area Under the Concentration-time Curve in Plasma Over the Time Interval From 0 Extrapolated to Infinity for BI 6727 BS

AUC (0-inf); area under the concentration-time curve in plasma over the time interval from 0 extrapolated to infinity for BI 6727 BS (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionng*h/mL (Geometric Mean)
Volasertib6240

AUC (0-inf); Area Under the Concentration-time Curve in Plasma Over the Time Interval From 0 Extrapolated to Infinity for CD 10899 BS

AUC (0-inf); area under the concentration-time curve in plasma over the time interval from 0 extrapolated to infinity for CD 10899 BS (metabolite of Volasertib BI 6727) (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionng*h/mL (Geometric Mean)
Volasertib1400

Biological Progression-free Survival Based on Serum Cancer Antigen 125 (CA-125) According to the Gynaecologic Cancer Intergroup (GCIG) Criteria

"Biological PFS including assessment of CA-125 levels was defined as the time from randomisation until the first occurrence of progressive disease according to CA-125, progressive disease according to radiological evidence, or death.~Also according to the below criterias,~In patients with radiological measurable disease, disease progression during study treatment could not be declared on the basis of CA-125 alone.~Patients with elevated CA-125 pre-treatment and normalization of CA-125 had to show evidence of CA-125 ≥ to two times the upper normal limit on two occasions at least one week apart or~Patients with elevated CA-125 pre-treatment, which never normalized, had to show evidence of CA-125 ≥ to two times the nadir value on two occasions at least one week apart or~Patients with CA-125 in the normal range pre-treatment had to show evidence of CA-125 ≥ to two times the upper normal limit on two occasions at least one week apart." (NCT01121406)
Timeframe: At screening and every 6 weeks thereafter (Up to 213 weeks )

Interventionweeks (Median)
Volasertib (BI 6727)13.1
Cytotoxic20.6

CL; Total Clearance of BI 6727 BS in Plasma After Intravenous Administration

CL; total clearance of BI 6727 BS in plasma after intravenous administration (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

InterventionmL/min (Geometric Mean)
Volasertib801

Cmax; Maximum Measured Concentration of BI 6727 BS in Plasma

Cmax; maximum measured concentration of BI 6727 BS in plasma (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionng/mL (Geometric Mean)
Volasertib341

Cmax; Maximum Measured Concentration of CD 10899 BS in Plasma

Cmax; maximum measured concentration of CD 10899 BS (metabolite of Volasertib BI 6727) in plasma (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionng/mL (Geometric Mean)
Volasertib10.8

Disease Control Rate (DCR) at Week 24 According to Response Evaluation Criteria In Solid Tumours (RECIST) Version 1.1

DCR was defined as the proportion of patients who had an overall response of complete response (CR), partial response (PR), or stable disease (SD). (NCT01121406)
Timeframe: Week 24

Interventionpercentage of participants (Number)
Volasertib (BI 6727)30.6
Cytotoxic43.1

MRT; Mean Residence Time of BI 6727 BS in the Body

MRT; Mean residence time of BI 6727 BS in the body (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionhours (Geometric Mean)
Volasertib118

Overall Survival (OS)

OS is defined as time from randomisation to death irrespective of the cause of the death. (NCT01121406)
Timeframe: From randomization until death or study discontinuation; Up to 213 weeks

Interventionweeks (Median)
Volasertib (BI 6727)60.1
Cytotoxic68.6

Progression Free Survival (PFS)

"Progression-free survival of a patient was based on the investigator's assessment; it was defined as the number of days from the date of randomisation until the date of either disease progression or death from any cause, whichever occurred first.~Definition of disease progression according to RECIST version 1.1; Patients with measurable tumour lesions at baseline, Target-lesions: at least a 20% increase in the sum of diameters of target lesions, the sum of diameters must also demonstrate an absolute increase of at least 5 mm,taking as reference the smallest sum on study, or appearance of 1 or more new lesions.~Non-target lesions: unequivocal progression of existing non-target lesions or appearance of 1 or more new lesions Patients with non-measurable tumour lesions at baseline, Non-target lesions: requires unequivocal progression of existing non-target lesions or appearance of 1 or more new lesions" (NCT01121406)
Timeframe: From randomization until disease progression, death or study discontinuation; Up to 213 weeks

Interventionweeks (Median)
Volasertib (BI 6727)13.1
Cytotoxic20.6

t1/2; Terminal Half-life of BI 6727 BS in Plasma

t1/2; Terminal half-life of BI 6727 BS in plasma (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionhours (Geometric Mean)
Volasertib143

t1/2; Terminal Half-life of CD 10899 BS in Plasma

t1/2; Terminal half-life of CD 10899 BS in plasma (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionhours (Geometric Mean)
Volasertib146

Time to Deterioration in Abdominal Bloating/ Quality of Life (QOL)

"Time to deterioration in abdominal bloating/ Quality of life (QOL) and symptom control assessed by the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-OV28, and individual symptom questionnaires.~The time to deterioration was defined as the time from randomisation to a score increased (i.e. worsened) by at least 10 points from baseline (0-100 point scale). If score is missing, and patient died within 28 days after scheduled time for completion, the patient was considered deteriorated. In this case, time to deterioration is time to death." (NCT01121406)
Timeframe: Every 6 weeks (Up to 213 weeks )

Interventionweeks (Median)
Volasertib (BI 6727)NA
Cytotoxic47.2

Time to Deterioration in Fatigue/Quality of Life (QOL)

"Time to deterioration in fatigue/Quality of life (QOL) and symptom control assessed by the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-OV28, and individual symptom questionnaires.~The time to deterioration was defined as the time from randomisation to a score increased (i.e. worsened) by at least 10 points from baseline (0-100 point scale). If score is missing, and patient died within 28 days after scheduled time for completion, the patient was considered deteriorated. In this case, time to deterioration is time to death." (NCT01121406)
Timeframe: Every 6 weeks (Up to 213 weeks )

Interventionweeks (Median)
Volasertib (BI 6727)NA
Cytotoxic67.1

Time to Deterioration in Global Health Status/Quality of Life (QOL)

"Time to deterioration in global health status/Quality of life (QOL) and symptom control assessed by the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-OV28, and individual symptom questionnaires.~The time to deterioration was defined as the time from randomisation to a score increased (i.e. worsened) by at least 10 points from baseline (0-100 point scale). If score is missing, and patient died within 28 days after scheduled time for completion, the patient was considered deteriorated. In this case, time to deterioration is time to death." (NCT01121406)
Timeframe: Every 6 weeks (Up to 213 weeks )

Interventionweeks (Median)
Volasertib (BI 6727)NA
Cytotoxic39.6

Time to Deterioration in Pain/ Quality of Life (QOL)

"Time to deterioration in pain/ Quality of life (QOL) and symptom control assessed by the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-OV28, and individual symptom questionnaires.~The time to deterioration was defined as the time from randomisation to a score increased (i.e. worsened) by at least 10 points from baseline (0-100 point scale). If score is missing, and patient died within 28 days after scheduled time for completion, the patient was considered deteriorated. In this case, time to deterioration is time to death." (NCT01121406)
Timeframe: Every 6 weeks (Up to 213 weeks )

Interventionweeks (Median)
Volasertib (BI 6727)NA
Cytotoxic54.1

Time to Deterioration in the Three Most Troublesome Disease Specific Symptoms/ Quality of Life (QOL)

"Three most troublesome disease specific symptoms, defined by the patient at baseline.~Patients that have defined more than 3 most troublesome symptoms have not been taken into account in the analysis.~Quality of life (QOL) and symptom control assessed by the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, QLQ-OV28, and individual symptom questionnaires.~The time to deterioration was defined as the time from randomisation to a score increased (i.e. worsened) by at least 10 points from baseline (0-100 point scale). If score is missing, and patient died within 28 days after scheduled time for completion, the patient was considered deteriorated. In this case, time to deterioration is time to death." (NCT01121406)
Timeframe: Every 6 weeks (Up to 213 weeks)

Interventionweeks (Median)
Volasertib (BI 6727)NA
Cytotoxic18.9

Tmax; Time From Dosing to Maximum Measured Concentration of BI 6727 BS in Plasma

tmax; time from dosing to maximum measured concentration of BI 6727 BS in plasma (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionhours (Median)
Volasertib2.00

Tmax; Time From Dosing to Maximum Measured Concentration of CD 10899 BS in Plasma

tmax; time from dosing to maximum measured concentration of CD 10899 BS (metabolite of Volasertib BI 6727) in plasma (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

Interventionhours (Median)
Volasertib6.07

Vss;Apparent Volume of Distribution at Steady State Following Intravenous Administration for BI 6727 BS

Vss;apparent volume of distribution at steady state following intravenous administration for BI 6727 BS (NCT01121406)
Timeframe: -0.083 hours (h), 2h, 4h, 6h, 24h, 168h and 336 h after first drug administration

InterventionLitres (Geometric Mean)
Volasertib5690

Best Overall Response

"Best overall response (BOR) is defined as the best response recorded at any time from the date of randomisation until the end of treatment.~Missing categories signify that no tumour imaging has been performed post baseline, and therefore the response status could not be assessed." (NCT01121406)
Timeframe: time from the date of randomisation until study completion/discontinuation; Up to 213 weeks

,
Interventionparticipants (Number)
CR- Measurable diseasePR- Measurable diseaseSD- Measurable diseasePD- Measurable diseaseMissing- Measurable diseaseCR- Non-measurable diseaseNon-CR/Non-PD- Non-measurable diseasePD- Non-measurable diseaseMissing- Non-measurable disease
Cytotoxic08241021901
Volasertib (BI 6727)07241400630

Biological Tumour Response Based on Serum Cancer Antigen 125 (CA-125) According to the Gynaecologic Cancer Intergroup (GCIG) Criteria

"Patients were to have a pre-treatment CA-125 of at least twice the upper limit of normal to be considered for CA-125 response. Patients were not evaluable by CA-125 if they had received mouse antibodies or if they had undergone medical and/or surgical interference with their peritoneum or pleura during the previous 28 days. In eligible patients, a CA-125 response was defined as the moment the CA- 25 was reduced by 50%, with this being confirmed with a consecutive CA-125 assessment not earlier than 28 days after the previous one.~Biological response rate based on serum CA-125 levels was assessed according to the guidelines by the Gynaecologic Cancer Intergroup. Monitoring of blood levels of the tumour marker CA-125 was performed at screening and every 6 weeks thereafter." (NCT01121406)
Timeframe: At screening and every 6 weeks thereafter (Up to 213 weeks)

,
Interventionparticipants (Number)
YesNoNot evaluableMissing
Cytotoxic1223119
Volasertib (BI 6727)103347

Clinically Relevant Changes in Laboratory and ECG Data

Clinically relevant changes in laboratory and ECG data (NCT01121406)
Timeframe: From first treatment administration to 21 days after the last drug administration (Up to 1403 days)

,,
Interventionpercentage of participants (Number)
Blood alkaline phosphatase increasedBlood creatinine increasedPlatelet count decreasedAlanine aminotransferase increasedAspartate aminotransferase increasedBlood uric acid increasedGamma-glutamyltransferase increasedAlanine aminotransferase abnormalElectrocardiogram QT prolongedHaemoglobin decreasedNeutrophil count decreasedTroponin I increasedBlood lactate dehydrogenase increasedBlood magnesium decreasedWhite blood cell count decreasedBlood urea increasedAlanine aminotransferase decreasedBlood bilirubin increasedBlood creatine phosphokinase decreasedBlood potassium decreasedHepatic enzyme increasedAspartate aminotransferase abnormalTransaminases increased
Cytotoxic12.73.60.09.15.55.55.50.00.03.60.00.00.00.00.03.60.00.00.00.00.01.81.8
Cytotoxic to Volasertib Switch8.30.08.34.24.20.04.24.24.24.24.24.20.00.00.00.00.00.00.00.00.00.00.0
Volasertib (BI 6727)3.79.39.31.93.71.93.70.00.03.71.90.03.73.73.71.91.91.91.91.91.90.00.0

Incidence and Intensity of Adverse Events According to the United States National Cancer Institute (US NCI) Common Terminology Criteria for Adverse Events (CTCAE) Version 3.0

Incidence and intensity of adverse events according to the United States National Cancer Institute (US NCI) Common Terminology Criteria for Adverse Events (CTCAE) version 3.0 (NCT01121406)
Timeframe: From first treatment administration to 21 days after the last drug administration (Up to 1403 days)

,,
Interventionparticipants (Number)
Grade 1Grade 2Grade 3Grade 4Grade 5
Cytotoxic3192553
Cytotoxic to Volasertib Switch13963
Volasertib (BI 6727)4616253

Reviews

1 review available for pteridines and Ovarian Neoplasms

ArticleYear
Prise en charge médicale de la récidive du cancer épithélial de l'ovaire: Medical management of recurrent epithelial ovarian cancer.
    Bulletin du cancer, 2021, Volume: 108, Issue:9S1

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Immunological; Antineoplastic Combined Che

2021

Trials

2 trials available for pteridines and Ovarian Neoplasms

ArticleYear
Volasertib Versus Chemotherapy in Platinum-Resistant or -Refractory Ovarian Cancer: A Randomized Phase II Groupe des Investigateurs Nationaux pour l'Etude des Cancers de l'Ovaire Study.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, Mar-01, Volume: 34, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Carboplatin; Cisplatin; Di

2016
Multicentric parallel phase II trial of the polo-like kinase 1 inhibitor BI 2536 in patients with advanced head and neck cancer, breast cancer, ovarian cancer, soft tissue sarcoma and melanoma. The first protocol of the European Organization for Research
    European journal of cancer (Oxford, England : 1990), 2010, Volume: 46, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Feasibility Studies; Female; Head and Neck Neo

2010

Other Studies

6 other studies available for pteridines and Ovarian Neoplasms

ArticleYear
α
    Acta biomaterialia, 2021, 04-01, Volume: 124

    Topics: Animals; Cell Line, Tumor; Female; Humans; Integrin alpha3; Mice; Molecular Targeted Therapy; Ovaria

2021
Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors.
    Communications biology, 2021, 03-03, Volume: 4, Issue:1

    Topics: Adjuvants, Immunologic; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Lin

2021
Fluorescence characteristics of human urine from normal individuals and ovarian cancer patients.
    Neoplasma, 2013, Volume: 60, Issue:5

    Topics: Adult; Aged; Early Detection of Cancer; Female; Humans; Middle Aged; Optical Imaging; Ovarian Neopla

2013
Differences in pteridine urinary levels in patients with malignant and benign ovarian tumors in comparison with healthy individuals.
    Journal of photochemistry and photobiology. B, Biology, 2015, Volume: 153

    Topics: Adult; Aged; Biopterins; Chromatography, High Pressure Liquid; Female; Humans; Manganese Compounds;

2015
BET Bromodomain Inhibition as a Therapeutic Strategy in Ovarian Cancer by Downregulating FoxM1.
    Theranostics, 2016, Volume: 6, Issue:2

    Topics: Animals; Antineoplastic Agents; Azepines; Carcinoma; Cell Line, Tumor; Down-Regulation; Female; Fork

2016
Significance of urinary neopterine in gynecological oncology: follow-up of patients with ovarian cancer.
    Cancer detection and prevention, 1983, Volume: 6, Issue:1-2

    Topics: Adult; Aged; Biopterins; Female; Follow-Up Studies; Humans; Middle Aged; Neopterin; Ovarian Neoplasm

1983