pteridines has been researched along with Leukemia in 11 studies
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Emergence of resistance to Tyrosine-Kinase Inhibitors (TKIs), such as imatinib, dasatinib and nilotinib, in Chronic Myelogenous Leukemia (CML) demands new therapeutic strategies." | 3.79 | Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells. ( Bertomeu, T; Bucur, O; Dewar, R; Goganau, I; Khosravi-Far, R; Pennarun, B; Petrescu, SM; Stancu, AL, 2013) |
| " Through in vitro growth inhibition studies, Western blot analysis for the expression and activation of key regulators of cell growth and survival and gene silencing studies, we specifically examined the ability of these agents to induce cytotoxicity through the activation of apoptosis and their capacity to interact and modulate the expression and phosphorylation of Aurora kinases." | 1.51 | Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells. ( Boklan, J; Dunn, SE; Hofmann, B; Jayanthan, A; Meier-Stephenson, V; Narendran, A; Perinpanayagam, M; Trippett, TM; Truong, TH, 2019) |
| "In patients with tumors of the genitourinary tract or with hemopoietic neoplasms, urinary neopterin levels were correlated with the tumor burden and became normal when remission was achieved." | 1.27 | Urinary neopterin in the diagnosis and follow-up of neoplasia: a biochemical parameter to detect cell-mediated immune response. ( Fuchs, D; Hausen, A; Huber, C; Reibnegger, G; Wachter, H, 1984) |
| "In cases of chronic and acute lymphocytic leukemias the low amounts of biopterin in the red cell fraction agreed with the current view of partial extinction of the erythropoietic line." | 1.26 | Biopterin level in peripheral blood cells as a marker for hemopoietic cell proliferation during leukemia and polycythemia vera. ( Fink, M; Wilmanns, W; Ziegler, I, 1982) |
| "Marked increases during extended cancer and especially during leukemias corroborated the view that P-AGPM may be identical with abnormal orosomucoid." | 1.26 | Blood levels of a pteridine-binding alpha 1-acid glycoprotein in cancer patients. ( Fink, M; Maier, K; Wilmanns, W; Ziegler, I, 1982) |
| "Those of patients with multiple myeloma stage I were only raised to near the upper limit of healthy subjects." | 1.26 | Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy. ( Fuchs, D; Grünewald, K; Hausen, A; Huber, H; König, K; Wachter, H, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (72.73) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ruiz-Alcaraz, AJ | 1 |
| Carmona-Martínez, V | 1 |
| Guirado, A | 1 |
| Gálvez, J | 1 |
| Martínez-Esparza, M | 1 |
| García-Peñarrubia, P | 1 |
| Jayanthan, A | 1 |
| Hofmann, B | 1 |
| Meier-Stephenson, V | 1 |
| Perinpanayagam, M | 1 |
| Dunn, SE | 1 |
| Boklan, J | 1 |
| Trippett, TM | 1 |
| Truong, TH | 1 |
| Narendran, A | 1 |
| Bucur, O | 1 |
| Stancu, AL | 1 |
| Goganau, I | 1 |
| Petrescu, SM | 1 |
| Pennarun, B | 1 |
| Bertomeu, T | 1 |
| Dewar, R | 1 |
| Khosravi-Far, R | 1 |
| Niederwieser, D | 1 |
| Huber, C | 2 |
| Gratwohl, A | 1 |
| Bannert, P | 1 |
| Fuchs, D | 4 |
| Hausen, A | 4 |
| Reibnegger, G | 2 |
| Speck, B | 1 |
| Wachter, H | 4 |
| Ziegler, I | 2 |
| Fink, M | 2 |
| Wilmanns, W | 2 |
| Maier, K | 1 |
| Grünewald, K | 2 |
| Huber, H | 2 |
| König, K | 2 |
| Leeming, RJ | 1 |
| Blair, JA | 1 |
| Melikian, V | 1 |
| O'Gorman, DJ | 1 |
| Lee, WW | 1 |
| Martinez, AP | 1 |
| Goodman, L | 1 |
11 other studies available for pteridines and Leukemia
| Article | Year |
|---|---|
Anti-leukemia activity of 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines.
Topics: Antineoplastic Agents; HL-60 Cells; Humans; K562 Cells; Leukemia; Leukocytes, Mononuclear; Pteridine | 2019 |
Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells.
Topics: Apoptosis; Aurora Kinases; Azepines; Cell Cycle Proteins; Cell Proliferation; Humans; Leukemia; Polo | 2019 |
Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells.
Topics: Benzamides; Boronic Acids; Bortezomib; Caspases; Cell Death; Cell Line, Tumor; Dasatinib; Down-Regul | 2013 |
Neopterin as a new biochemical marker in the clinical monitoring of bone marrow transplant recipients.
Topics: Biopterins; Bone Marrow Transplantation; Chromatography, High Pressure Liquid; Clinical Laboratory T | 1984 |
Urinary neopterin in the diagnosis and follow-up of neoplasia: a biochemical parameter to detect cell-mediated immune response.
Topics: Adolescent; Adult; Aged; Biopterins; Female; Follow-Up Studies; Genital Neoplasms, Female; Humans; I | 1984 |
Biopterin level in peripheral blood cells as a marker for hemopoietic cell proliferation during leukemia and polycythemia vera.
Topics: Biopterins; Erythrocytes; Hematopoiesis; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Le | 1982 |
Blood levels of a pteridine-binding alpha 1-acid glycoprotein in cancer patients.
Topics: Biopterins; Carrier Proteins; Humans; Leukemia; Neoplasms; Orosomucoid; Pteridines | 1982 |
Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy.
Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Biopterins; Female; Humans; Hypergammaglobulinemia; Leuk | 1982 |
Urinary neopterine as marker for haematological neoplasias.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Biopterins; Chromatography, High Pressure Liquid; Cl | 1981 |
Biopterin derivatives in human body fluids and tissues.
Topics: Adolescent; Adult; Biological Assay; Biopterins; Body Fluids; Brain Chemistry; Chemical Phenomena; C | 1976 |
Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid.
Topics: Animals; Chlorine; Folic Acid Antagonists; Glutamates; Humans; Leukemia; Leukemia L1210; Methotrexat | 1974 |