Page last updated: 2024-10-20

pteridines and Leukemia

pteridines has been researched along with Leukemia in 11 studies

Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)

Research Excerpts

ExcerptRelevanceReference
"Emergence of resistance to Tyrosine-Kinase Inhibitors (TKIs), such as imatinib, dasatinib and nilotinib, in Chronic Myelogenous Leukemia (CML) demands new therapeutic strategies."3.79Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells. ( Bertomeu, T; Bucur, O; Dewar, R; Goganau, I; Khosravi-Far, R; Pennarun, B; Petrescu, SM; Stancu, AL, 2013)
" Through in vitro growth inhibition studies, Western blot analysis for the expression and activation of key regulators of cell growth and survival and gene silencing studies, we specifically examined the ability of these agents to induce cytotoxicity through the activation of apoptosis and their capacity to interact and modulate the expression and phosphorylation of Aurora kinases."1.51Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells. ( Boklan, J; Dunn, SE; Hofmann, B; Jayanthan, A; Meier-Stephenson, V; Narendran, A; Perinpanayagam, M; Trippett, TM; Truong, TH, 2019)
"In patients with tumors of the genitourinary tract or with hemopoietic neoplasms, urinary neopterin levels were correlated with the tumor burden and became normal when remission was achieved."1.27Urinary neopterin in the diagnosis and follow-up of neoplasia: a biochemical parameter to detect cell-mediated immune response. ( Fuchs, D; Hausen, A; Huber, C; Reibnegger, G; Wachter, H, 1984)
"In cases of chronic and acute lymphocytic leukemias the low amounts of biopterin in the red cell fraction agreed with the current view of partial extinction of the erythropoietic line."1.26Biopterin level in peripheral blood cells as a marker for hemopoietic cell proliferation during leukemia and polycythemia vera. ( Fink, M; Wilmanns, W; Ziegler, I, 1982)
"Marked increases during extended cancer and especially during leukemias corroborated the view that P-AGPM may be identical with abnormal orosomucoid."1.26Blood levels of a pteridine-binding alpha 1-acid glycoprotein in cancer patients. ( Fink, M; Maier, K; Wilmanns, W; Ziegler, I, 1982)
"Those of patients with multiple myeloma stage I were only raised to near the upper limit of healthy subjects."1.26Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy. ( Fuchs, D; Grünewald, K; Hausen, A; Huber, H; König, K; Wachter, H, 1982)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19908 (72.73)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (27.27)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ruiz-Alcaraz, AJ1
Carmona-Martínez, V1
Guirado, A1
Gálvez, J1
Martínez-Esparza, M1
García-Peñarrubia, P1
Jayanthan, A1
Hofmann, B1
Meier-Stephenson, V1
Perinpanayagam, M1
Dunn, SE1
Boklan, J1
Trippett, TM1
Truong, TH1
Narendran, A1
Bucur, O1
Stancu, AL1
Goganau, I1
Petrescu, SM1
Pennarun, B1
Bertomeu, T1
Dewar, R1
Khosravi-Far, R1
Niederwieser, D1
Huber, C2
Gratwohl, A1
Bannert, P1
Fuchs, D4
Hausen, A4
Reibnegger, G2
Speck, B1
Wachter, H4
Ziegler, I2
Fink, M2
Wilmanns, W2
Maier, K1
Grünewald, K2
Huber, H2
König, K2
Leeming, RJ1
Blair, JA1
Melikian, V1
O'Gorman, DJ1
Lee, WW1
Martinez, AP1
Goodman, L1

Other Studies

11 other studies available for pteridines and Leukemia

ArticleYear
Anti-leukemia activity of 4-amino-2-aryl-6,9-dichlorobenzo[g]pteridines.
    Naunyn-Schmiedeberg's archives of pharmacology, 2019, Volume: 392, Issue:2

    Topics: Antineoplastic Agents; HL-60 Cells; Humans; K562 Cells; Leukemia; Leukocytes, Mononuclear; Pteridine

2019
Targeted Polo-like Kinase Inhibition Combined With Aurora Kinase Inhibition in Pediatric Acute Leukemia Cells.
    Journal of pediatric hematology/oncology, 2019, Volume: 41, Issue:6

    Topics: Apoptosis; Aurora Kinases; Azepines; Cell Cycle Proteins; Cell Proliferation; Humans; Leukemia; Polo

2019
Combination of bortezomib and mitotic inhibitors down-modulate Bcr-Abl and efficiently eliminates tyrosine-kinase inhibitor sensitive and resistant Bcr-Abl-positive leukemic cells.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Benzamides; Boronic Acids; Bortezomib; Caspases; Cell Death; Cell Line, Tumor; Dasatinib; Down-Regul

2013
Neopterin as a new biochemical marker in the clinical monitoring of bone marrow transplant recipients.
    Transplantation, 1984, Volume: 38, Issue:5

    Topics: Biopterins; Bone Marrow Transplantation; Chromatography, High Pressure Liquid; Clinical Laboratory T

1984
Urinary neopterin in the diagnosis and follow-up of neoplasia: a biochemical parameter to detect cell-mediated immune response.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 1984, Volume: 5, Issue:3-4

    Topics: Adolescent; Adult; Aged; Biopterins; Female; Follow-Up Studies; Genital Neoplasms, Female; Humans; I

1984
Biopterin level in peripheral blood cells as a marker for hemopoietic cell proliferation during leukemia and polycythemia vera.
    Blut, 1982, Volume: 44, Issue:4

    Topics: Biopterins; Erythrocytes; Hematopoiesis; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Le

1982
Blood levels of a pteridine-binding alpha 1-acid glycoprotein in cancer patients.
    Cancer research, 1982, Volume: 42, Issue:4

    Topics: Biopterins; Carrier Proteins; Humans; Leukemia; Neoplasms; Orosomucoid; Pteridines

1982
Urinary neopterine in the assessment of lymphoid and myeloid neoplasia, and neopterine levels in haemolytic anaemia and benign monoclonal gammopathy.
    Clinical biochemistry, 1982, Volume: 15, Issue:1

    Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Biopterins; Female; Humans; Hypergammaglobulinemia; Leuk

1982
Urinary neopterine as marker for haematological neoplasias.
    Clinica chimica acta; international journal of clinical chemistry, 1981, Dec-24, Volume: 117, Issue:3

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Biopterins; Chromatography, High Pressure Liquid; Cl

1981
Biopterin derivatives in human body fluids and tissues.
    Journal of clinical pathology, 1976, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Biological Assay; Biopterins; Body Fluids; Brain Chemistry; Chemical Phenomena; C

1976
Folic acid antagonists. Methotrexate analogs containing spurious amino acids. Dichlorohomofolic acid.
    Journal of medicinal chemistry, 1974, Volume: 17, Issue:3

    Topics: Animals; Chlorine; Folic Acid Antagonists; Glutamates; Humans; Leukemia; Leukemia L1210; Methotrexat

1974