pteridines has been researched along with Disease Models, Animal in 29 studies
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For this reason, in a series of preclinical studies, we tested the potential of a recently developed small-molecule inhibitor of these two isoforms, TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol], as a form of anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD)." | 7.75 | Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. ( Acevedo, LM; Cheresh, DA; Dellamary, L; Dneprovskaia, E; Doukas, J; Eide, L; Martin, M; Noronha, G; Racanelli-Layton, A; Soll, R; Stebbins, K; Wrasidlo, W, 2009) |
| "After evaluating the pharmacokinetics, pharmacodynamics and tolerability of oral GS-9620 in uninfected woodchucks, adult woodchucks chronically infected with WHV (n = 7 per group) were dosed with GS-9620 or placebo for 4 or 8 weeks with different treatment schedules." | 5.42 | Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B. ( AlDeghaither, D; Baldwin, BH; Bellezza, CA; Cote, PJ; Daffis, S; Fletcher, SP; Fosdick, A; Halcomb, R; Li, L; Liu, KH; Menne, S; Tennant, BC; Thampi, L; Tumas, DB; Wolfgang, GH; Yue, P; Zheng, J, 2015) |
| "GS-9620, an oral agonist of toll-like receptor 7, is in clinical development for the treatment of chronic hepatitis B (CHB)." | 3.88 | Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells. ( Barry, V; Daffis, S; Delaney, WE; Fletcher, SP; French, DM; Huntzicker, E; Lanford, RE; Li, L; Mikaelian, I; Niu, C, 2018) |
| "By using a mouse model of osteosarcoma induced by paratibial injection of cells, we assessed the impact of Smad7 overexpression or SD-208 on tumor growth, tumor microenvironment, bone remodeling, and metastasis development." | 3.80 | Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma. ( Amiaud, J; Bougras, G; Chesneau, J; Heymann, D; Heymann, MF; Lamora, A; Le Deley, MC; Leduc, M; Redini, F; Stresing, V; Talbot, J; Taurelle, J; Verrecchia, F, 2014) |
| " For this reason, in a series of preclinical studies, we tested the potential of a recently developed small-molecule inhibitor of these two isoforms, TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol], as a form of anti-inflammatory therapy for respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD)." | 3.75 | Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. ( Acevedo, LM; Cheresh, DA; Dellamary, L; Dneprovskaia, E; Doukas, J; Eide, L; Martin, M; Noronha, G; Racanelli-Layton, A; Soll, R; Stebbins, K; Wrasidlo, W, 2009) |
| "Multiple myeloma is a plasma cell malignancy that causes debilitating bone disease and fractures, in which TGFβ plays a central role." | 1.51 | TGFβ Inhibition Stimulates Collagen Maturation to Enhance Bone Repair and Fracture Resistance in a Murine Myeloma Model. ( Chantry, AD; Down, JM; Evans, HR; Green, AC; Hudson, K; Lath, D; Lawson, MA; Owen, R; Paton-Hough, J; Reilly, GC; Walkley, B, 2019) |
| "Here, we generated mice with experimental autoimmune encephalomyelitis (EAE) and treated them with BI-D1870." | 1.43 | The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice. ( Makishima, M; Takada, I; Yogiashi, Y, 2016) |
| "After evaluating the pharmacokinetics, pharmacodynamics and tolerability of oral GS-9620 in uninfected woodchucks, adult woodchucks chronically infected with WHV (n = 7 per group) were dosed with GS-9620 or placebo for 4 or 8 weeks with different treatment schedules." | 1.42 | Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B. ( AlDeghaither, D; Baldwin, BH; Bellezza, CA; Cote, PJ; Daffis, S; Fletcher, SP; Fosdick, A; Halcomb, R; Li, L; Liu, KH; Menne, S; Tennant, BC; Thampi, L; Tumas, DB; Wolfgang, GH; Yue, P; Zheng, J, 2015) |
| "TGF-β upregulates in prostate cancer cells a set of genes associated with cancer aggressiveness and bone metastases, and the most upregulated gene was PMEPA1." | 1.42 | The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone. ( Chirgwin, JM; Clines, GA; Fournier, PG; Guise, TA; Jiang, G; Juárez, P; Kim, HS; Liu, Y; Mohammad, KS; Niewolna, M; Peng, XH; Walton, HW; Wells, CD, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.90) | 18.7374 |
| 1990's | 2 (6.90) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 18 (62.07) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Green, AC | 1 |
| Lath, D | 1 |
| Hudson, K | 1 |
| Walkley, B | 1 |
| Down, JM | 1 |
| Owen, R | 1 |
| Evans, HR | 1 |
| Paton-Hough, J | 1 |
| Reilly, GC | 1 |
| Lawson, MA | 1 |
| Chantry, AD | 1 |
| Yu, J | 1 |
| Xu, H | 1 |
| Cui, J | 1 |
| Chen, S | 1 |
| Zhang, H | 1 |
| Zou, Y | 1 |
| Zhao, J | 1 |
| Le, S | 1 |
| Jiang, L | 1 |
| Chen, Z | 1 |
| Liu, H | 1 |
| Zhang, D | 1 |
| Xia, J | 1 |
| Wu, J | 2 |
| Nguyen, T | 1 |
| Parker, R | 1 |
| Hawkins, E | 1 |
| Holkova, B | 1 |
| Yazbeck, V | 1 |
| Kolluri, A | 1 |
| Kmieciak, M | 1 |
| Rahmani, M | 1 |
| Grant, S | 1 |
| Duncan, C | 1 |
| Jamieson, FB | 1 |
| Troudt, J | 1 |
| Izzo, L | 1 |
| Bielefeldt-Ohmann, H | 1 |
| Izzo, A | 1 |
| Mehaffy, C | 1 |
| Li, L | 3 |
| Barry, V | 1 |
| Daffis, S | 2 |
| Niu, C | 1 |
| Huntzicker, E | 1 |
| French, DM | 1 |
| Mikaelian, I | 1 |
| Lanford, RE | 1 |
| Delaney, WE | 1 |
| Fletcher, SP | 2 |
| Zhang, Q | 1 |
| Zhao, B | 1 |
| Chen, X | 1 |
| Song, N | 1 |
| Li, G | 1 |
| Yu, P | 1 |
| Han, Y | 1 |
| Liu, J | 1 |
| Qin, C | 1 |
| Rosania, K | 1 |
| Fingas, CD | 1 |
| Mertens, JC | 1 |
| Razumilava, N | 1 |
| Sydor, S | 1 |
| Bronk, SF | 1 |
| Christensen, JD | 1 |
| Rizvi, SH | 1 |
| Canbay, A | 1 |
| Treckmann, JW | 1 |
| Paul, A | 1 |
| Sirica, AE | 1 |
| Gores, GJ | 1 |
| Lamora, A | 1 |
| Talbot, J | 1 |
| Bougras, G | 1 |
| Amiaud, J | 1 |
| Leduc, M | 1 |
| Chesneau, J | 1 |
| Taurelle, J | 1 |
| Stresing, V | 1 |
| Le Deley, MC | 1 |
| Heymann, MF | 1 |
| Heymann, D | 1 |
| Redini, F | 1 |
| Verrecchia, F | 1 |
| Menne, S | 1 |
| Tumas, DB | 1 |
| Liu, KH | 1 |
| Thampi, L | 1 |
| AlDeghaither, D | 1 |
| Baldwin, BH | 1 |
| Bellezza, CA | 1 |
| Cote, PJ | 1 |
| Zheng, J | 1 |
| Halcomb, R | 1 |
| Fosdick, A | 1 |
| Yue, P | 1 |
| Wolfgang, GH | 1 |
| Tennant, BC | 1 |
| Fournier, PG | 2 |
| Juárez, P | 1 |
| Jiang, G | 1 |
| Clines, GA | 1 |
| Niewolna, M | 2 |
| Kim, HS | 1 |
| Walton, HW | 1 |
| Peng, XH | 2 |
| Liu, Y | 2 |
| Mohammad, KS | 2 |
| Wells, CD | 1 |
| Chirgwin, JM | 1 |
| Guise, TA | 2 |
| Hugle, M | 1 |
| Belz, K | 1 |
| Fulda, S | 1 |
| Takada, I | 1 |
| Yogiashi, Y | 1 |
| Makishima, M | 1 |
| Pontiki, E | 1 |
| Hadjipavlou-Litina, D | 1 |
| Patsilinakos, A | 1 |
| Tran, TM | 1 |
| Marson, CM | 1 |
| Ferrarotto, R | 1 |
| Goonatilake, R | 1 |
| Yoo, SY | 1 |
| Tong, P | 1 |
| Giri, U | 1 |
| Peng, S | 1 |
| Minna, J | 1 |
| Girard, L | 1 |
| Wang, Y | 1 |
| Wang, L | 1 |
| Diao, L | 1 |
| Peng, DH | 1 |
| Gibbons, DL | 1 |
| Glisson, BS | 1 |
| Heymach, JV | 1 |
| Wang, J | 2 |
| Byers, LA | 1 |
| Johnson, FM | 1 |
| Jakubiczka-Smorag, J | 1 |
| Santamaria-Araujo, JA | 1 |
| Metz, I | 1 |
| Kumar, A | 1 |
| Hakroush, S | 1 |
| Brueck, W | 1 |
| Schwarz, G | 3 |
| Burfeind, P | 1 |
| Reiss, J | 3 |
| Smorag, L | 1 |
| Kaneda, MM | 1 |
| Cappello, P | 1 |
| Nguyen, AV | 1 |
| Ralainirina, N | 1 |
| Hardamon, CR | 1 |
| Foubert, P | 1 |
| Schmid, MC | 1 |
| Sun, P | 1 |
| Mose, E | 1 |
| Bouvet, M | 1 |
| Lowy, AM | 1 |
| Valasek, MA | 1 |
| Sasik, R | 1 |
| Novelli, F | 1 |
| Hirsch, E | 1 |
| Varner, JA | 1 |
| Luo, B | 1 |
| Han, F | 1 |
| Xu, K | 1 |
| Liu, Z | 1 |
| Shen, Z | 1 |
| Li, J | 1 |
| Jiang, M | 1 |
| Zhang, ZY | 1 |
| Zhang, Z | 1 |
| Muregi, FW | 1 |
| Kino, H | 1 |
| Ishih, A | 1 |
| Doukas, J | 1 |
| Eide, L | 1 |
| Stebbins, K | 1 |
| Racanelli-Layton, A | 1 |
| Dellamary, L | 1 |
| Martin, M | 1 |
| Dneprovskaia, E | 1 |
| Noronha, G | 1 |
| Soll, R | 1 |
| Wrasidlo, W | 1 |
| Acevedo, LM | 1 |
| Cheresh, DA | 1 |
| Javelaud, D | 1 |
| McKenna, CR | 1 |
| Duong, V | 1 |
| Dunn, LK | 1 |
| Mauviel, A | 1 |
| Lee, HJ | 2 |
| Adham, IM | 1 |
| Kneussel, M | 1 |
| Sass, JO | 2 |
| Engel, W | 2 |
| Bonin, M | 1 |
| Schwegler, H | 1 |
| Garattini, E | 1 |
| Wagner, S | 1 |
| Riess, O | 1 |
| Sakata, Y | 1 |
| Chancey, AL | 1 |
| Divakaran, VG | 1 |
| Sekiguchi, K | 1 |
| Sivasubramanian, N | 1 |
| Mann, DL | 1 |
| Sanford, YM | 1 |
| Orias, E | 1 |
| Cottam, HB | 1 |
| Shih, H | 1 |
| Tehrani, LR | 1 |
| Wasson, DB | 1 |
| Carson, DA | 1 |
| Strohmaier, W | 1 |
| Werner, ER | 1 |
| Wachter, H | 1 |
| Redl, H | 1 |
| Schlag, G | 1 |
| Meininger, CJ | 1 |
| Marinos, RS | 1 |
| Hatakeyama, K | 1 |
| Martinez-Zaguilan, R | 1 |
| Rojas, JD | 1 |
| Kelly, KA | 1 |
| Wu, G | 1 |
| Cotton, RG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 2 Window of Opportunity Study of IPI-549 in Patients With Locally Advanced HPV+ and HPV- Head and Neck Squamous Cell Carcinoma[NCT03795610] | Phase 2 | 15 participants (Anticipated) | Interventional | 2020-03-06 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
29 other studies available for pteridines and Disease Models, Animal
| Article | Year |
|---|---|
TGFβ Inhibition Stimulates Collagen Maturation to Enhance Bone Repair and Fracture Resistance in a Murine Myeloma Model.
Topics: Alkaline Phosphatase; Animals; Bone Remodeling; Bortezomib; Cancellous Bone; Collagen; Disease Model | 2019 |
PLK1 Inhibition alleviates transplant-associated obliterative bronchiolitis by suppressing myofibroblast differentiation.
Topics: Actins; Allografts; Animals; Bronchiolitis Obliterans; Cell Cycle Proteins; Cell Differentiation; Ce | 2020 |
Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin's lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms.
Topics: Animals; Caspases; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation | 2017 |
Whole transcriptomic and proteomic analyses of an isogenic M. tuberculosis clinical strain with a naturally occurring 15 Kb genomic deletion.
Topics: Animals; Bacterial Proteins; Coenzymes; Disease Models, Animal; DNA-Binding Proteins; Gene Deletion; | 2017 |
Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cells.
Topics: Animals; Antiviral Agents; B-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Aggregation; Disease Mode | 2018 |
GS-9620 inhibits enterovirus 71 replication mainly through the NF-κB and PI3K-AKT signaling pathways.
Topics: Animals; Antiviral Agents; Cytokines; Disease Models, Animal; Enterovirus A, Human; Hand, Foot and M | 2018 |
Relying on chimpanzees for hepatitis research.
Topics: Animal Use Alternatives; Animals; Antiviral Agents; Disease Models, Animal; Hepacivirus; Hepatitis B | 2013 |
Polo-like kinase 2 is a mediator of hedgehog survival signaling in cholangiocarcinoma.
Topics: Animals; Apoptosis; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Cell Line, Tumor; Cell Survival; | 2013 |
Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.
Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line, Tumor; Disease Models, Animal; Female; Gene Exp | 2014 |
Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B.
Topics: Animals; Antiviral Agents; Disease Models, Animal; DNA, Viral; Hepatitis Antibodies; Hepatitis Antig | 2015 |
The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Disease Models, Animal; | 2015 |
Identification of synthetic lethality of PLK1 inhibition and microtubule-destabilizing drugs.
Topics: Animals; Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; Cell Cycle Checkpoints; Cell Cycle P | 2015 |
The ribosomal S6 kinase inhibitor BI-D1870 ameliorated experimental autoimmune encephalomyelitis in mice.
Topics: Animals; Cell Movement; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmun | 2016 |
Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents; Binding Sites; Colitis; Diamines; Disease Models, Animal; Edema; | 2015 |
Epithelial-Mesenchymal Transition Predicts Polo-Like Kinase 1 Inhibitor-Mediated Apoptosis in Non-Small Cell Lung Cancer.
Topics: Animals; Apoptosis; Benzimidazoles; Carcinoma, Non-Small-Cell Lung; Cell Cycle Checkpoints; Cell Cyc | 2016 |
Mouse model for molybdenum cofactor deficiency type B recapitulates the phenotype observed in molybdenum cofactor deficient patients.
Topics: Animals; Apoptosis; Carbon-Carbon Lyases; Coenzymes; Cysteine; Disease Models, Animal; Gene Expressi | 2016 |
Macrophage PI3Kγ Drives Pancreatic Ductal Adenocarcinoma Progression.
Topics: Animals; Antineoplastic Agents; Biomarkers; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Cell Mov | 2016 |
Resolvin D1 Programs Inflammation Resolution by Increasing TGF-β Expression Induced by Dying Cell Clearance in Experimental Autoimmune Neuritis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cells, Cultured; Disease Models, Animal; Docosahexaeno | 2016 |
Plasmodium berghei: lack of antimalarial activity of an analogue of folate precursor, 2,4-diamino-6-hydroxymethylpteridine in a mouse model.
Topics: Aminopterin; Animals; Antimalarials; Disease Models, Animal; Folic Acid Antagonists; Malaria; Male; | 2008 |
Aerosolized phosphoinositide 3-kinase gamma/delta inhibitor TG100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease.
Topics: Administration, Intranasal; Aerosols; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreac | 2009 |
TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.
Topics: Animals; Base Sequence; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Disease Progressio | 2011 |
Molybdenum cofactor-deficient mice resemble the phenotype of human patients.
Topics: Animals; Carbon-Carbon Lyases; Coenzymes; Disease Models, Animal; Humans; Metalloproteins; Mice; Mic | 2002 |
The pathogenesis of molybdenum cofactor deficiency, its delay by maternal clearance, and its expression pattern in microarray analysis.
Topics: Animals; Brain; Carbon-Carbon Lyases; Cluster Analysis; Coenzymes; Disease Models, Animal; DNA, Comp | 2005 |
Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor.
Topics: Analysis of Variance; Animals; Cardiomegaly; Disease Models, Animal; Fetus; Fibrillar Collagens; Fib | 2008 |
Phenylketonuric Tetrahymena: phenylalanine hydroxylase mutants and other tyrosine auxotrophs.
Topics: Animals; Disease Models, Animal; Humans; Mutation; Phenylalanine Hydroxylase; Phenylketonurias; Pter | 1981 |
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; Animals; Anti-I | 1996 |
Pteridine and nitrite/nitrate formation in experimental septic and traumatic shock.
Topics: Animals; Arteries; Cardiac Output; Creatinine; Disease Models, Animal; Escherichia coli Infections; | 1996 |
Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency.
Topics: Animals; Arginine; Biopterins; Calcium; Calmodulin; Chromatography, High Pressure Liquid; Diabetes M | 2000 |
A model for hyperphenylalaninaemia due to tetrahydrobiopterin deficiency.
Topics: Animals; Biopterins; Brain; Catecholamines; Disease Models, Animal; Dose-Response Relationship, Drug | 1986 |