Page last updated: 2024-10-20

pteridines and Chronic Hepatitis C

pteridines has been researched along with Chronic Hepatitis C in 2 studies

Research Excerpts

ExcerptRelevanceReference
" In healthy volunteers, low doses of GS-9620 (2, 4 and 6 mg) induced significant expression of peripheral interferon-stimulated-gene (ISG) mRNA in the absence of detectable serum interferon-α and systemic adverse events (AEs)."6.80Safety, pharmacokinetics and pharmacodynamics of the oral toll-like receptor 7 agonist GS-9620 in treatment-naive patients with chronic hepatitis C. ( Freilich, B; Gaggar, A; Gruener, D; Hassman, D; Hill, J; Jacobson, IM; Lawitz, E; Marbury, T; Massetto, B; McHutchison, JG; Mogalian, E; Nguyen, AH; Pflanz, S; Rodriguez-Torres, M; Subramanian, GM; Webster, L, 2015)
" In healthy volunteers, low doses of GS-9620 (2, 4 and 6 mg) induced significant expression of peripheral interferon-stimulated-gene (ISG) mRNA in the absence of detectable serum interferon-α and systemic adverse events (AEs)."2.80Safety, pharmacokinetics and pharmacodynamics of the oral toll-like receptor 7 agonist GS-9620 in treatment-naive patients with chronic hepatitis C. ( Freilich, B; Gaggar, A; Gruener, D; Hassman, D; Hill, J; Jacobson, IM; Lawitz, E; Marbury, T; Massetto, B; McHutchison, JG; Mogalian, E; Nguyen, AH; Pflanz, S; Rodriguez-Torres, M; Subramanian, GM; Webster, L, 2015)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Younossi, ZM1
Stepanova, M1
Younossi, I1
Papatheodoridis, G1
Janssen, HLA1
Agarwal, K1
Nguyen, MH1
Gane, E1
Tsai, N1
Nader, F1
Lawitz, E1
Gruener, D1
Marbury, T1
Hill, J1
Webster, L1
Hassman, D1
Nguyen, AH1
Pflanz, S1
Mogalian, E1
Gaggar, A1
Massetto, B1
Subramanian, GM1
McHutchison, JG1
Jacobson, IM1
Freilich, B1
Rodriguez-Torres, M1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-Blind, Randomized, Placebo-Controlled, Single and Multiple-Dose Ranging Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antiviral Activity of GS-9620 in Treatment Naive Subjects With Chronic Hepatitis C Virus In[NCT01591668]Phase 151 participants (Actual)Interventional2012-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for pteridines and Chronic Hepatitis C

ArticleYear
Patient-reported outcomes in patients chronic viral hepatitis without cirrhosis: The impact of hepatitis B and C viral replication.
    Liver international : official journal of the International Association for the Study of the Liver, 2019, Volume: 39, Issue:10

    Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Female; Hepatitis B, Chronic; Hepatitis C, Chron

2019
Safety, pharmacokinetics and pharmacodynamics of the oral toll-like receptor 7 agonist GS-9620 in treatment-naive patients with chronic hepatitis C.
    Antiviral therapy, 2015, Volume: 20, Issue:7

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Biomarkers; Cytokines; Female; Gene Expression; Genotype;

2015