Page last updated: 2024-10-20

pteridines and Brain Neoplasms

pteridines has been researched along with Brain Neoplasms in 11 studies

Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Research Excerpts

ExcerptRelevanceReference
"Glioblastoma (GBM) is the deadliest primary brain tumor that is highly resistant to current treatments."1.56Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC. ( Chen, G; Deng, Z; Feng, M; Feng, Z; Li, X; Li, Y; Pan, T; Tao, Z; Wang, H; Yin, H; Zhao, G; Zhou, Y, 2020)
"Medulloblastoma is the most common malignant brain tumor in children."1.39Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children. ( Berns, R; Bouffet, E; Dunham, C; Dunn, SE; Foster, C; Fotovati, A; Hawkins, C; Hukin, J; Lee, C; Manoranjan, B; Narendran, A; Northcott, P; O'Halloran, K; Pambid, MR; Ramaswamy, V; Rassekh, R; Singh, SK; Singhal, A; Taylor, MD; Triscott, J; Venugopal, C; Yip, S, 2013)
"Gliomas are the most devastating of primary adult malignant brain tumors."1.38Glioma-propagating cells as an in vitro screening platform: PLK1 as a case study. ( Ang, BT; Brooks, HB; Campbell, RM; Chong, YK; Foong, CS; Sandanaraj, E; Tang, C, 2012)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (72.73)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Li, X2
Tao, Z2
Wang, H2
Deng, Z2
Zhou, Y2
Du, Z1
Feng, M1
Zhao, G1
Yin, H1
Pan, T1
Chen, G1
Feng, Z1
Li, Y1
Zhu, Z1
Wang, J1
Tan, J1
Yao, YL1
He, ZC1
Xie, XQ1
Yan, ZX1
Fu, WJ1
Liu, Q1
Wang, YX1
Luo, T1
Bian, XW1
Schmidt, C1
Schubert, NA1
Brabetz, S1
Mack, N1
Schwalm, B1
Chan, JA1
Selt, F1
Herold-Mende, C1
Witt, O1
Milde, T1
Pfister, SM1
Korshunov, A1
Kool, M1
Triscott, J2
Lee, C2
Foster, C1
Manoranjan, B1
Pambid, MR1
Berns, R1
Fotovati, A2
Venugopal, C2
O'Halloran, K1
Narendran, A2
Hawkins, C1
Ramaswamy, V1
Bouffet, E1
Taylor, MD1
Singhal, A2
Hukin, J1
Rassekh, R1
Yip, S2
Northcott, P1
Singh, SK2
Dunham, C2
Dunn, SE2
Danovi, D1
Folarin, A1
Gogolok, S1
Ender, C1
Elbatsh, AM1
Engström, PG1
Stricker, SH1
Gagrica, S1
Georgian, A1
Yu, D1
U, KP1
Harvey, KJ1
Ferretti, P1
Paddison, PJ1
Preston, JE1
Abbott, NJ1
Bertone, P1
Smith, A1
Pollard, SM1
Amani, V1
Prince, EW1
Alimova, I1
Balakrishnan, I1
Birks, D1
Donson, AM1
Harris, P1
Levy, JM1
Handler, M1
Foreman, NK1
Venkataraman, S1
Vibhakar, R1
Xiao, D1
Yue, M1
Su, H1
Ren, P1
Jiang, J1
Li, F1
Hu, Y1
Du, H1
Liu, H1
Qing, G1
Grinshtein, N1
Datti, A1
Fujitani, M1
Uehling, D1
Prakesch, M1
Isaac, M1
Irwin, MS1
Wrana, JL1
Al-Awar, R1
Kaplan, DR1
Chen, J1
Kerr, JM1
Verreault, M1
Wakimoto, H1
Jones, C1
Jayanthan, A1
Foong, CS1
Sandanaraj, E1
Brooks, HB1
Campbell, RM1
Ang, BT1
Chong, YK1
Tang, C1

Other Studies

11 other studies available for pteridines and Brain Neoplasms

ArticleYear
Dual inhibition of Src and PLK1 regulate stemness and induce apoptosis through Notch1-SOX2 signaling in EGFRvIII positive glioma stem cells (GSCs).
    Experimental cell research, 2020, 11-01, Volume: 396, Issue:1

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzodioxoles; Brain Neoplasms; Cell Cycle Proteins; Cell

2020
Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC.
    Biochemical and biophysical research communications, 2020, 12-10, Volume: 533, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Carcinogenesis; Cell Cycle Proteins; Cel

2020
Calcyphosine promotes the proliferation of glioma cells and serves as a potential therapeutic target.
    The Journal of pathology, 2021, Volume: 255, Issue:4

    Topics: Adult; Aged; Animals; Apoptosis; Brain Neoplasms; Calcium-Binding Proteins; Cell Cycle; Cell Prolife

2021
Preclinical drug screen reveals topotecan, actinomycin D, and volasertib as potential new therapeutic candidates for ETMR brain tumor patients.
    Neuro-oncology, 2017, Nov-29, Volume: 19, Issue:12

    Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Brain Neoplasms; Cell Cycle; Cell Proliferation; Ch

2017
Personalizing the treatment of pediatric medulloblastoma: Polo-like kinase 1 as a molecular target in high-risk children.
    Cancer research, 2013, Nov-15, Volume: 73, Issue:22

    Topics: Adolescent; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Cycle Proteins; Child; Child, Pres

2013
A high-content small molecule screen identifies sensitivity of glioblastoma stem cells to inhibition of polo-like kinase 1.
    PloS one, 2013, Volume: 8, Issue:10

    Topics: Animals; Benzimidazoles; Blood-Brain Barrier; Blotting, Western; Brain Neoplasms; Cell Cycle Checkpo

2013
Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma.
    BMC cancer, 2016, 08-18, Volume: 16

    Topics: Brain Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damag

2016
Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival.
    Molecular cell, 2016, 11-03, Volume: 64, Issue:3

    Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle

2016
Small molecule kinase inhibitor screen identifies polo-like kinase 1 as a target for neuroblastoma tumor-initiating cells.
    Cancer research, 2011, Feb-15, Volume: 71, Issue:4

    Topics: Algorithms; Animals; Brain Neoplasms; Cell Cycle Proteins; Cells, Cultured; High-Throughput Screenin

2011
Polo-like kinase 1 inhibition kills glioblastoma multiforme brain tumor cells in part through loss of SOX2 and delays tumor progression in mice.
    Stem cells (Dayton, Ohio), 2012, Volume: 30, Issue:6

    Topics: Animals; Apoptosis; Brain Neoplasms; Cell Cycle Proteins; Cell Growth Processes; Cell Line, Tumor; D

2012
Glioma-propagating cells as an in vitro screening platform: PLK1 as a case study.
    Journal of biomolecular screening, 2012, Volume: 17, Issue:9

    Topics: Animals; Brain Neoplasms; Cell Cycle Proteins; Cell Proliferation; Cell Survival; Computational Biol

2012