pteridines has been researched along with Bone Neoplasms in 10 studies
Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings support the further exploration of volasertib for pediatric malignancies, particularly alveolar rhabdomyosarcoma, and its combination with mitotic spindle poison." | 3.83 | Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies. ( Abbou, S; Daudigeos-Dubus, E; Geoerger, B; Lanvers-Kaminsky, C; Laplace-Builhe, C; LE Dret, L; Molenaar, J; Vassal, G, 2016) |
| "By using a mouse model of osteosarcoma induced by paratibial injection of cells, we assessed the impact of Smad7 overexpression or SD-208 on tumor growth, tumor microenvironment, bone remodeling, and metastasis development." | 3.80 | Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma. ( Amiaud, J; Bougras, G; Chesneau, J; Heymann, D; Heymann, MF; Lamora, A; Le Deley, MC; Leduc, M; Redini, F; Stresing, V; Talbot, J; Taurelle, J; Verrecchia, F, 2014) |
| " In this study, we tested the second-generation PLK1 inhibitors BI 6727 and GSK461364 in HOS and MG-63 cell lines, both as a single agent and in combination with methotrexate, cisplatin, vinblastine, doxorubicin, or ionizing radiation." | 1.42 | BI 6727 and GSK461364 suppress growth and radiosensitize osteosarcoma cells, but show limited cytotoxic effects when combined with conventional treatments. ( Bogado, RF; Brassesco, MS; de Oliveira, HF; Pezuk, JA; Tone, LG, 2015) |
| "We used murine invasive lobular breast carcinoma cells (KEP) that were generated by targeted deletion of E-cadherin and p53 in a conditional K14cre;Cdh1((F/F));Trp53((F/F)) mouse model of de novo mammary tumour formation." | 1.42 | Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGFβ receptor I kinase. ( Buijs, JT; Cheung, H; Cohen, R; Corver, WE; Guise, TA; Jonkers, J; Kruithof-de Julio, M; Matula, KM; Mohammad, KS; Snoeks, TJ; van der Mark, MH; van der Pluijm, G, 2015) |
| "TGF-β upregulates in prostate cancer cells a set of genes associated with cancer aggressiveness and bone metastases, and the most upregulated gene was PMEPA1." | 1.42 | The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone. ( Chirgwin, JM; Clines, GA; Fournier, PG; Guise, TA; Jiang, G; Juárez, P; Kim, HS; Liu, Y; Mohammad, KS; Niewolna, M; Peng, XH; Walton, HW; Wells, CD, 2015) |
| "Osteosarcoma is the most common type of primary bone cancer in children and adolescents." | 1.37 | Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo. ( Choy, E; Duan, Z; Harmon, D; Hornicek, FJ; Liu, X; Mankin, H; Yang, C; Yang, S, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (90.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lund-Andersen, C | 1 |
| Patzke, S | 1 |
| Nähse-Kumpf, V | 1 |
| Syljuåsen, RG | 1 |
| Bogado, RF | 1 |
| Pezuk, JA | 1 |
| de Oliveira, HF | 1 |
| Tone, LG | 1 |
| Brassesco, MS | 1 |
| Lamora, A | 1 |
| Talbot, J | 1 |
| Bougras, G | 1 |
| Amiaud, J | 1 |
| Leduc, M | 1 |
| Chesneau, J | 1 |
| Taurelle, J | 1 |
| Stresing, V | 1 |
| Le Deley, MC | 1 |
| Heymann, MF | 1 |
| Heymann, D | 1 |
| Redini, F | 1 |
| Verrecchia, F | 1 |
| Buijs, JT | 1 |
| Matula, KM | 1 |
| Cheung, H | 1 |
| Kruithof-de Julio, M | 1 |
| van der Mark, MH | 1 |
| Snoeks, TJ | 1 |
| Cohen, R | 1 |
| Corver, WE | 1 |
| Mohammad, KS | 3 |
| Jonkers, J | 1 |
| Guise, TA | 3 |
| van der Pluijm, G | 1 |
| Fournier, PG | 2 |
| Juárez, P | 1 |
| Jiang, G | 1 |
| Clines, GA | 1 |
| Niewolna, M | 2 |
| Kim, HS | 1 |
| Walton, HW | 1 |
| Peng, XH | 2 |
| Liu, Y | 1 |
| Wells, CD | 1 |
| Chirgwin, JM | 1 |
| Weiß, LM | 1 |
| Hugle, M | 1 |
| Romero, S | 1 |
| Fulda, S | 1 |
| Abbou, S | 1 |
| Lanvers-Kaminsky, C | 1 |
| Daudigeos-Dubus, E | 1 |
| LE Dret, L | 1 |
| Laplace-Builhe, C | 1 |
| Molenaar, J | 1 |
| Vassal, G | 1 |
| Geoerger, B | 1 |
| Javelaud, D | 1 |
| McKenna, CR | 1 |
| Duong, V | 1 |
| Dunn, LK | 1 |
| Mauviel, A | 1 |
| Liu, X | 1 |
| Choy, E | 1 |
| Harmon, D | 1 |
| Yang, S | 1 |
| Yang, C | 1 |
| Mankin, H | 1 |
| Hornicek, FJ | 1 |
| Duan, Z | 1 |
| Goldberg, M | 1 |
| Gassner, F | 1 |
| Merkenschlager, M | 1 |
10 other studies available for pteridines and Bone Neoplasms
| Article | Year |
|---|---|
PLK1-inhibition can cause radiosensitization or radioresistance dependent on the treatment schedule.
Topics: Bone Neoplasms; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Chemoradiotherapy; | 2014 |
BI 6727 and GSK461364 suppress growth and radiosensitize osteosarcoma cells, but show limited cytotoxic effects when combined with conventional treatments.
Topics: Antineoplastic Agents; Apoptosis; Benzimidazoles; Bone Neoplasms; Cell Cycle Checkpoints; Cell Cycle | 2015 |
Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.
Topics: Animals; Bone Neoplasms; Bone Resorption; Cell Line, Tumor; Disease Models, Animal; Female; Gene Exp | 2014 |
Spontaneous bone metastases in a preclinical orthotopic model of invasive lobular carcinoma; the effect of pharmacological targeting TGFβ receptor I kinase.
Topics: Animals; Apoptosis; Bone Neoplasms; Breast Neoplasms; Carcinoma, Lobular; Cdh1 Proteins; Cell Line, | 2015 |
The TGF-β Signaling Regulator PMEPA1 Suppresses Prostate Cancer Metastases to Bone.
Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Disease Models, Animal; | 2015 |
Synergistic induction of apoptosis by a polo-like kinase 1 inhibitor and microtubule-interfering drugs in Ewing sarcoma cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bone Neoplasms; Cell C | 2016 |
Polo-like Kinase Inhibitor Volasertib Exhibits Antitumor Activity and Synergy with Vincristine in Pediatric Malignancies.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Bone Neoplasm | 2016 |
TGF-beta-RI kinase inhibitor SD-208 reduces the development and progression of melanoma bone metastases.
Topics: Animals; Base Sequence; Bone Neoplasms; Cell Line, Tumor; Disease Models, Animal; Disease Progressio | 2011 |
Inhibition of polo-like kinase 1 leads to the suppression of osteosarcoma cell growth in vitro and in vivo.
Topics: Animals; Bone Neoplasms; Cell Cycle Proteins; Cell Division; Cell Growth Processes; Cell Line, Tumor | 2011 |
Altered urinary excretion of pteridines in dogs with various tumours.
Topics: Anal Gland Neoplasms; Animals; Bone Neoplasms; Dog Diseases; Dogs; Female; Male; Mammary Glands, Ani | 1987 |