pteridines has been researched along with Alzheimer Disease in 5 studies
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Brains from subjects with senile dementia of Alzheimer type retain their ability to synthesis neopterin and have normal dihydropteridine reductase activity, indicating a specific loss of ability to convert dihydroneopterin triphosphate to tetrahydrobiopterin." | 1.27 | Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type. ( Barford, PA; Blair, JA; Eggar, C; Hamon, C; Morar, C; Whitburn, SB, 1984) |
| "Patients with senile dementia could possibly be benefited by the administration of 5-methyltetrahydrofolate." | 1.27 | The effect of tetrahydrofolate on tetrahydrobiopterin metabolism. ( Barford, PA; Blair, JA; Hamon, CG, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, I | 1 |
| Barford, PA | 2 |
| Blair, JA | 3 |
| Eggar, C | 1 |
| Hamon, C | 1 |
| Morar, C | 2 |
| Whitburn, SB | 2 |
| Leeming, RJ | 1 |
| Wilcock, GK | 1 |
| Kay, AD | 1 |
| Milstien, S | 1 |
| Kaufman, S | 1 |
| Creasey, H | 1 |
| Haxby, JV | 1 |
| Cutler, NR | 1 |
| Rapoport, SI | 1 |
| Hamon, CG | 1 |
5 other studies available for pteridines and Alzheimer Disease
| Article | Year |
|---|---|
Significantly lower mean plasma total biopterin in 18 patients with senile dementia of Alzheimer type.
Topics: Aged; Alzheimer Disease; Biopterins; Creatinine; Humans; Phenylalanine; Pteridines | 1984 |
Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type.
Topics: Aged; Alzheimer Disease; Biopterins; Dihydropteridine Reductase; Humans; Kinetics; Neopterin; Pterid | 1984 |
Tetrahydrobiopterin metabolism in senile dementia of Alzheimer type.
Topics: Aged; Alzheimer Disease; Biopterins; Chromatography, High Pressure Liquid; Dementia; Humans; Middle | 1983 |
Cerebrospinal fluid biopterin is decreased in Alzheimer's disease.
Topics: Adult; Aged; Alzheimer Disease; Biopterins; Dopamine; Female; Homovanillic Acid; Humans; Hydroxyindo | 1986 |
The effect of tetrahydrofolate on tetrahydrobiopterin metabolism.
Topics: Adult; Aged; Alzheimer Disease; Animals; Biopterins; Child, Preschool; Humans; In Vitro Techniques; | 1986 |