psoralidin and Osteoporosis--Postmenopausal

psoralidin has been researched along with Osteoporosis--Postmenopausal* in 1 studies

Other Studies

1 other study(ies) available for psoralidin and Osteoporosis--Postmenopausal

ArticleYear
[Study on effect of psoralidin on anti-experimental postmenopausal osteoporosis and its mechanism].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2013, Volume: 38, Issue:11

    To observe the effect of psoralidine in rats with ovariectomy, and preliminarily study its mechanism.. Sixty female Sprague-Dawley rats were divided into 5 groups: the sham operation group, the model group, the psoralidine low-dose group (4 mg x kg(-1)), the psoralidine high-dose group (16 mg x kg(-1)) and the Zhuangguzhitong capsule group, with 12 rats in each group. Thirteen weeks later, their blood and bone samples were collected to detect bone density, bone biochemistry, pathomorphology, serum E2 and CT.. Psoralidine could up-regulate the bone density of lumbar vertebra and thighbone of rats with ovariectomy (P < 0.05), the maximum bending strength of thighbone (P < 0.05), and serum E2 and CT (P < 0.05).. Psoralidine has a good active effect on postmenopausal antiosteoporosis. Its mechanism may be related to such pathways as E2 and CT.

    Topics: Animals; Benzofurans; Bone Density; Coumarins; Drugs, Chinese Herbal; Estradiol; Female; Humans; Osteoporosis, Postmenopausal; Rats; Rats, Sprague-Dawley

2013