psn-632408 and Diabetes-Mellitus--Type-2

psn-632408 has been researched along with Diabetes-Mellitus--Type-2* in 1 studies

Other Studies

1 other study(ies) available for psn-632408 and Diabetes-Mellitus--Type-2

Article	Year
Discovery of structurally novel, potent and orally efficacious GPR119 agonists. Bioorganic & medicinal chemistry letters, 2014, May-15, Volume: 24, Issue:10 Screening hit 5 was identified in a biochemical screen for GPR119 agonists. Compound 5 was structurally novel, displayed modest biochemical activity and no oral exposure, but was structurally distinct from typical GPR119 agonist scaffolds. Systematic optimization led to compound 36 with significantly improved in vitro activity and oral exposure, to elevate GLP1 acutely in an in vivo mouse model at a dose of 10mg/kg. Topics: Animals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Pyrazoles; Pyrimidines; Receptors, G-Protein-Coupled; Structure-Activity Relationship	2014

Article

Year

Discovery of structurally novel, potent and orally efficacious GPR119 agonists.

Bioorganic & medicinal chemistry letters, 2014, May-15, Volume: 24, Issue:10

Screening hit 5 was identified in a biochemical screen for GPR119 agonists. Compound 5 was structurally novel, displayed modest biochemical activity and no oral exposure, but was structurally distinct from typical GPR119 agonist scaffolds. Systematic optimization led to compound 36 with significantly improved in vitro activity and oral exposure, to elevate GLP1 acutely in an in vivo mouse model at a dose of 10mg/kg.

Topics: Animals; Diabetes Mellitus, Type 2; Humans; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Pyrazoles; Pyrimidines; Receptors, G-Protein-Coupled; Structure-Activity Relationship

2014