psma-617 and Carcinoma--Hepatocellular

Topics: Carcinoma, Hepatocellular; Dipeptides; Gallium Radioisotopes; Humans; Liver Neoplasms; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography

Hepatocellular carcinoma (HCC) is a malignant tumor associated with high morbidity and mortality rates. In many non-prostate solid tumors such as HCC, prostate-specific membrane antigens (PSMA) are overexpressed in tumor-associated endothelial cells. Therefore, the aim of this study was to evaluate the performance of [. [. Low PSMA expression level of HepG2 and HuH-7 cells was observed, and the cellular uptake and blocking study confirmed the non-specificity of the PSMA-targeted probe binding to HepG2 and HuH-7 cells. In the subcutaneous xenograft models, the tumor uptakes at 0.5 h were 0.76 ± 0.12%ID/g (HepG2 tumors) and 0.78 ± 0.08%ID/g (HuH-7 tumors), respectively, which were significantly higher than those of the blocking groups (0.23 ± 0.04%ID/g and 0.20 ± 0.04%ID/g, respectively). In the orthotopic xenograft models, PET images clearly displayed the tumor locations based on the preferential accumulation of [. In this study, in vivo PET on different types of HCC xenograft models illustrated high uptake within tumors, which confirmed that [

Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Dipeptides; Endothelial Cells; Endothelium; Gallium Radioisotopes; Glutamate Carboxypeptidase II; Heterocyclic Compounds, 1-Ring; Humans; Liver Neoplasms; Male; Positron-Emission Tomography; Prostate-Specific Antigen; Prostatic Neoplasms; Tissue Distribution