pseudomycin-a and Hemolysis

Similarly to other Pseudomonas lipodepsinonapeptides, pseudomycin A inhibits proton extrusion from maize roots, promotes closure of stomata in Vicia faba, necrosis of tobacco leaves, haemolysis of human erythrocytes, affects H(+)-ATPase activity and proton translocation in plasma membrane vesicles, and stimulates succinate respiration in pea mitochondria. In general, the biological activities of pseudomycin A are lower than those of syringomycin-E, the prototype member of this family of bacterial metabolities. This difference might depend on the diverse number and distribution of charged residues in the peptide moiety of these compounds.

Topics: Amino Acid Sequence; Bacterial Proteins; Cell Membrane; Erythrocytes; Hemolysis; Humans; Mitochondria; Nicotiana; Peptides, Cyclic; Pisum sativum; Plant Leaves; Plant Roots; Plants; Plants, Toxic; Proton-Translocating ATPases; Pseudomonas; Zea mays