pseudomycin-a and Candidiasis

pseudomycin-a has been researched along with Candidiasis* in 1 studies

Other Studies

1 other study(ies) available for pseudomycin-a and Candidiasis

Article	Year
Synthesis and evaluation of novel pseudomycin side-chain analogues. Part 3. Bioorganic & medicinal chemistry letters, 2001, Dec-03, Volume: 11, Issue:23 To increase the therapeutic utility of C-18 side-chain bearing pseudomycin analogue 2, we prepared additional analogues and prodrugs of 2 containing further modifications at various positions within its core structure. Each of the newly synthesized derivatives (10-15) exhibited reduced tail vein toxicity relative to the parent compound. Some of the new pseudomycin derivatives (e.g., 14) also showed improved in vivo antifungal activity relative to its corresponding parent compound. Topics: Animals; Antifungal Agents; Biochemistry; Candidiasis; Drug Evaluation, Preclinical; Mice; Microbial Sensitivity Tests; Peptides, Cyclic; Structure-Activity Relationship; Toxicity Tests	2001

Article

Year

Synthesis and evaluation of novel pseudomycin side-chain analogues. Part 3.

Bioorganic & medicinal chemistry letters, 2001, Dec-03, Volume: 11, Issue:23

To increase the therapeutic utility of C-18 side-chain bearing pseudomycin analogue 2, we prepared additional analogues and prodrugs of 2 containing further modifications at various positions within its core structure. Each of the newly synthesized derivatives (10-15) exhibited reduced tail vein toxicity relative to the parent compound. Some of the new pseudomycin derivatives (e.g., 14) also showed improved in vivo antifungal activity relative to its corresponding parent compound.

Topics: Animals; Antifungal Agents; Biochemistry; Candidiasis; Drug Evaluation, Preclinical; Mice; Microbial Sensitivity Tests; Peptides, Cyclic; Structure-Activity Relationship; Toxicity Tests

2001