psd-502 and Ureteral-Calculi

The objective of the study was to compare the efficacy of dimethyl sulfoxide (DMSO) mixed with lignocaine and eutectic mixture of local anesthetics (EMLA) cream as topically applied surface anesthetics in relieving pain during shock wave lithotripsy (SWL) in a prospective randomized study. Of the 160 patients, 80 patients received DMSO with lignocaine and 80 patients received EMLA cream, applied to the skin of the flank at the area of entry of shock waves. SWL was done with Seimens lithostar multiline lithotripter. The pain during the procedure was assessed using visual analog and verbal rating scores. The mean visual analog scale scores for the two groups were 3.03 for DMSO group and 4.43 for EMLA group. The difference of pain score on visual analog scale was statistically significant (p < 0.05). Similarly, the pain scores as rated on the verbal rating scale were also evaluated; the mean score on verbal rating scale were 2.34 for DMSO group and 3.00 for the EMLA group. The difference between the pain score on verbal rating scale was also found to be statistically significant (p < 0.05). Our study showed that DMSO with lignocaine is a better local anesthetic agent for SWL than EMLA cream. The stone fragmentation and clearance rates are also better in the DMSO group.

Topics: Administration, Cutaneous; Adolescent; Adult; Aged; Anesthetics, Local; Dimethyl Sulfoxide; Drug Therapy, Combination; Female; Humans; Kidney Calculi; Lidocaine; Lidocaine, Prilocaine Drug Combination; Lithotripsy; Male; Middle Aged; Ointments; Pain; Pain Measurement; Prilocaine; Prospective Studies; Treatment Outcome; Ureteral Calculi; Young Adult

Extracorporeal shock wave lithotripsy (ESWL&) can be painful. Of our population of patients treated with a Siemens Lithostar device 51.4% needed intravenous analgesia. A eutectic mixture of local anesthetics, a hydrophylic cream containing 25 mg. lidocaine and 25 mg. prilocaine per gm., proved to be effective for local analgesia. Therefore, we investigated its effectiveness during ESWL. With randomized, double-blind application the eutectic mixture of local anesthetics and placebo were evaluated in 83 patients according to the percentage of patients who required intravenous analgesia during ESWL. Of 40 patients treated with the eutectic mixture of local anesthetics 12 (30%) needed supplementary fentanyl citrate, compared to 23 of 43 (53%) placebo treated patients. Although there is no statistical significance (p = 0.32), the eutectic mixture of local anesthetics does decrease pain during ESWL and it should be particularly useful for patients in whom intravenous analgesia is contraindicated.

Topics: Adult; Aged; Aged, 80 and over; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Drug Combinations; Female; Humans; Kidney Calculi; Lidocaine; Lidocaine, Prilocaine Drug Combination; Lithotripsy; Male; Middle Aged; Ointments; Pain Measurement; Prilocaine; Prospective Studies; Ureteral Calculi