psd-502 and Purpura

Emla cream has been widely used as a local anaesthetic for superficial procedures. Blanching and redness are commonly observed side-effects. We observed purpura in 5 patients after application of Emla. Other authors have not reported this before. In 4 patients, purpura was observed after 30 min Emla application before the treatment of mollusca contagiosa. In 1 patient, Emla was used for 60 min before taking a lip biopsy. In these patients, patch tests were performed with the individual ingredients of Emla cream, Emla cream itself, placebo cream, and Tegaderm plaster. All tests were negative at an early reading after 30 min as well as after 2 and 3 days. We concluded that the purpuric reaction was not of an allergic nature. Possibly, it was caused by a toxic effect on the capillary endothelium.

Topics: Anesthetics, Local; Biopsy; Capillaries; Dermatitis, Contact; Drug Combinations; Endothelium, Vascular; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Lip; Molluscum Contagiosum; Occlusive Dressings; Ointments; Patch Tests; Placebos; Prilocaine; Purpura; Time Factors

Lidocaine/prilocaine cream is a topical anesthetic commonly used in pediatric and dermatologic practice to obtain local anesthesia. Common side effects include: transient skin blanching, erythema, urticaria, allergic contact dermatitis, irritant contact dermatitis, and hyperpigmentation. The authors report a petechial and purpuric reaction after the application of lidocaine/prilocaine cream. This is a rare side effect, since to our knowledge only few case reports have been documented in literature.

Topics: Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Drug Eruptions; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Ointments; Prilocaine; Purpura

Topics: Anesthetics, Combined; Anesthetics, Local; Child, Preschool; Drug Eruptions; Female; Humans; Infant; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Ointments; Prilocaine; Purpura

Topics: Anesthetics, Local; Drug Combinations; Humans; Infant, Newborn; Infant, Premature; Lidocaine; Lidocaine, Prilocaine Drug Combination; Prilocaine; Purpura