psd-502 and Hyperpigmentation

We assessed the effects of prior application of a eutectic mixture of local anesthetics (EMLA) on the appearance of dyschromia at the site of superficial electrodesiccation in an observer-blind, case-control study in 60 patients. Thirty subjects each were assigned to Groups A and B; both groups underwent radiofrequency (RFC) ablation for facial dermatosis papulosa nigrans (DPN). Group A received RFC ablation with prior application of EMLA, whereas Group B did not. No significant difference was observed in the dyschromia between both groups. EMLA cream was well tolerated by the study participants. (

Topics: Adult; Anesthetics, Local; Case-Control Studies; Double-Blind Method; Electrocoagulation; Facial Dermatoses; Female; Humans; Hyperpigmentation; Inflammation; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged

Liposomal lidocaine 4% (L.M.X.4 cream, Ferndale Laboratories Inc., Ferndale, MI, USA) has been proposed as a more rapidly acting topical anesthetic than the eutectic mixture of lidocaine 2.5% and prilocaine 2.5% (EMLA cream, AstraZeneca LP, Wilmington, DE, USA) for venipuncture and laser procedures. However, their anesthetic efficacy has not been previously compared for electrosurgical destruction of superficial skin lesions.. To test the hypothesis that L.M.X.4 and EMLA differ in anesthetic efficacy when applied under occlusion for 30 minutes prior to electrodesiccation of papules of dermatosis papulosa nigra.. Forty adults were randomly assigned to treatment with either agent for 30 minutes under Tegaderm. The study drug was administered for an additional 30 minutes if the electrodesiccation of the first few papules was too painful.. One subject treated with EMLA versus none treated with L.M.X.4 experienced complete anesthesia after a single 30-minute application. Nineteen of 20 (95%) subjects treated with EMLA versus 18 of 20 (90%) subjects treated with L.M.X.4 required only a single application (p = .49). Pain scores after the initial 30-minute application (scale: 0 = none to 10 = very severe) were EMLA 3.3 +/- 2.2 (mean +/- SD) versus L.M.X. 4 2.9 +/- 2.0 (p = .46).. EMLA and L.M.X.4 provide comparable levels of anesthesia after a single 30-minute application under occlusion prior to electrodesiccation of superficial skin lesions.

Topics: Administration, Cutaneous; Adult; Anesthesia, Local; Anesthetics, Local; Desiccation; Double-Blind Method; Electrosurgery; Female; Humans; Hyperpigmentation; Lidocaine; Lidocaine, Prilocaine Drug Combination; Liposomes; Male; Middle Aged; Prilocaine; Prospective Studies

Topics: Anesthetics, Local; Black People; Child; Drug Eruptions; Humans; Hyperpigmentation; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Ointments; Prilocaine