psd-502 and Herpes-Zoster

Topics: Anesthetics, Local; Drug Combinations; Herpes Zoster; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Ointments; Prilocaine

Topics: Anesthetics, Local; Drug Combinations; Herpes Zoster; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Neuralgia; Prilocaine

The analgesic efficacy of 5% of EMLA cream (5 or 10 g) when applied for 24 h periods was evaluated in 5 female and 7 male patients (mean age 69 years, range 50-85 years) with refractory post-herpetic neuralgia (PHN). Mean visual analogue pain intensity scores for all patients were significantly improved 6 h after application (P less than 0.05). In a subgroup of patients with facial PHN receiving EMLA cream, 5 g (n = 4), there were significant improvements in pain intensity scores at 6 h (P less than 0.05). 8 h (P less than 0.01) and 10 h (P less than 0.01) after application. Plasma lignocaine and plasma prilocaine concentrations were well below potentially toxic levels in all patients after application.

Topics: Administration, Topical; Aged; Aged, 80 and over; Analgesics; Drug Combinations; Female; Herpes Zoster; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Neuralgia; Prilocaine