psd-502 and Hemorrhoids

The study was undertaken to evaluate the efficacy of eutectic lidocaine/prilocaine (EMLA) cream for decreasing pain during local anaesthetic infiltration for outpatient haemorrhoidectomy.. Ninety-eight patients were randomly assigned either to receive EMLA or placebo. The creams were applied 45 minutes prior to injection of a lidocaine/bupivacaine mixture using a diamond-shaped perianal block. All participants were blinded to the specific medication received. They were asked to rate pain and levels of acceptability using a pre-validated pain scale and questionnaire.. There were 49 patients in each group. The baseline characteristics between the two groups were similar. Forty patients (82%) in the EMLA group and 42 patients (86%) in the placebo group reported only mild pain during injection and infiltration of the lidocaine/bupivacaine mixture. The mean rank pain scores were 49.11 and 48.89, respectively (p = 0.886, not significant).. While outpatient haemorrhoidectomy under local anaesthesia was generally well tolerated, there was no statistically significant difference between EMLA cream and placebo for decreasing pain during anaesthetic infiltration.

Topics: Adult; Ambulatory Surgical Procedures; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Female; Hemorrhoids; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Pain Measurement; Prilocaine; Treatment Outcome

Application of a topical anaesthetic agent may facilitate infiltration of local anaesthetic at haemorrhoidectomy.. A randomized clinical trial of 53 consecutive patients requiring elective haemorrhoidectomy was carried out. One group underwent haemorrhoidectomy under general anaesthesia, while the second group had topical anaesthetic cream (containing lignocaine and prilocaine) applied followed by local anaesthetic infiltration for surgical anaesthesia.. There were no differences between the two groups in terms of operating time, postoperative pain, nausea or vomiting, pain-free interval after operation, analgesic requirements or patients' satisfaction with the method of anaesthesia. Postoperative oxygen saturation and pulse rate were similar in the two groups.. Topical anaesthetic and local anaesthesia can be used effectively for haemorrhoidectomy and provide an alternative to general anaesthesia.

Topics: Adult; Aged; Anesthesia, General; Anesthetics, Combined; Anesthetics, Intravenous; Anesthetics, Local; Chi-Square Distribution; Electrocoagulation; Female; Hemorrhoids; Humans; Injections, Intralesional; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Ointments; Patient Satisfaction; Prilocaine; Proctoscopy; Propofol; Treatment Outcome

Topics: Adult; Anesthetics, Combined; Female; Hemorrhoids; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Prilocaine; Thrombosis