psd-502 and Facial-Pain

The aims of this study were to compare the topical anesthetic effect of two different preparations of lidocaine/prilocaine, cream versus thermosetting gel, on the reduction of pain from needle stick in the palate. The study also compared the subjects' preferences with regard to the substances.. Two preparations of 2.5% lidocaine/2.5% prilocaine topical anesthetic agents were applied on the palatal mucosa in the canine region bilaterally and blindly to forty subjects. In the same visit, the cream (EMLA) was applied on one side and the thermosetting gel (Oraqix) on the other side, simultaneously. After that, a needle stick was given on each side using a 27-gauge needle inserted to bone contact through the palatal mucosa every second minute during a ten-minute period. Immediately after the needle stick, the subjects started recording their findings using a verbal scale, a visual analogue scale, and a questionnaire form. Significant differences were set at p < 0.05.. Both substances reduced or eliminated pain from needle stick in the palate. Significant differences in pain reduction were observed between the two substances. EMLA reduced pain significantly better than Oraqix. With regard to comfort, taste, anesthetic effect, personal preference, and recommendation, the majority of the subjects favored the EMLA cream to the thermosetting gel. No adverse effects were reported by the subjects.. Although both topical anesthetic agents are similar in content, the cream seemed to be preferred by the patients and reduced pain from needle stick in the palate significantly better than the thermosetting gel.

Topics: Adult; Anesthetics, Local; Facial Pain; Female; Gels; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Needles; Ointments; Pain Measurement; Palate, Hard; Patient Satisfaction; Prilocaine; Single-Blind Method

Laser resurfacing is a painful procedure, and is therefore usually carried out under general anaesthetic or local anaesthetic with sedation. However, the small but significant risk of adverse events from either of these methods has resulted in an effort to develop other methods of controlling the pain associated with the use of lasers. This trial describes of the use of a cooling device (the CoolAnalgesia device) with a carbon dioxide laser. The only anaesthetic used was a eutectic mixture of lidocaine anaesthetic (EMLA) applied as a cream to the face at least 60 min prior to the procedure. Twenty consecutive patients attending two laser centres for facial resurfacing were recruited. Each patient was asked to assess the level of pain on a visual analogue scale from 1-10 every 2 min during lasering. Only one of the patients had a mean pain score for the duration of the treatment of above five, four patients recorded a pain score of above five at some stage during their treatment, but none requested that the treatment be stopped. It would appear that the CoolAnalgesia device in combination with EMLA cream provides a level of anaesthesia sufficient to allow laser resurfacing without the use of local anaesthetic injections or intra-venous agents.

Topics: Ambulatory Surgical Procedures; Anesthetics, Local; Cosmetic Techniques; Cryoanesthesia; Drug Combinations; Face; Facial Pain; Humans; Laser Therapy; Lidocaine; Lidocaine, Prilocaine Drug Combination; Patient Satisfaction; Prilocaine; Surveys and Questionnaires; Treatment Outcome

The purpose of this volunteer clinical trial was to compare the effects of 5% lidocaine ointment and EMLA cream on the discomfort associated with intraligamentary injections.. A double-blind, split mouth study was conducted. Each of 10 healthy volunteers had 5% lidocaine and EMLA cream applied to the maxillary premolar buccal gingiva for 5 minutes before the administration of an intraligamentary injection. Discomfort during the injection was assessed through use of a visual analog scale. Data were analyzed by means of Student paired and unpaired t tests.. Injection discomfort on the side on which EMLA cream was applied was significantly less than on the lidocaine side (t = 2.32, P < .05).. EMLA cream reduced the discomfort associated with intraligamentary injections.

Topics: Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Double-Blind Method; Facial Pain; Female; Humans; Injections; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Pain Measurement; Periodontal Ligament; Prilocaine

Atypical odontalgia is a distressing and unusual chronic orofacial pain condition. It is often difficult to diagnose because it is associated with a lack of clinical and radiographic abnormalities. The condition is poorly understood on a pathophysiological basis, and patients often undergo repetitive and unnecessary dental procedures in attempts to alleviate pain. In this study, 50 patients diagnosed with odontalgia were evaluated by pharmacological procedures, including topical anesthetic application and phentolamine infusion. Results of these pharmacological procedures suggest that atypical odontalgia is a neuropathic pain of the oral cavity that may have a component of sympathetically maintained pain. Therapeutic trials of topical capsaicin were carried out to assess its efficacy for pain reduction. Topical capsaicin was effective in most patients.

Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anesthetics, Combined; Anesthetics, Local; Capsaicin; Chi-Square Distribution; Chronic Disease; Facial Pain; Female; Humans; Infusions, Intravenous; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Pain Measurement; Phentolamine; Prilocaine; Reflex Sympathetic Dystrophy; Sex Factors; Single-Blind Method; Surveys and Questionnaires; Sympatholytics; Temporomandibular Joint Disorders; Toothache

The efficacy of a topical anesthetic on pain and unpleasantness provoked by scaling of gingival pockets was investigated in 20 patients with mild chronic periodontitis. A eutectic mixture of local anesthetics (EMLA) and a placebo cream, both occluded by Orahesive Oral Bandages, were applied in a balanced, randomized, double-blind, split-mouth design, which enabled within-subject comparison of the anesthetic and the placebo in the upper and the lower jaw. Pretreatment interviews showed that approximately two-thirds of the patients considered gingival scaling to be associated with some degree of pain and unpleasantness. Pain intensity and unpleasantness were evaluated on 100-mm visual analog scales (VAS). Application of EMLA reduced both pain intensity and unpleasantness significantly compared to placebo cream. Median reductions in VAS pain intensity in the upper and lower jaw were 58.9% and 61.9%, and corresponding reductions in VAS unpleasantness were 31.9% and 25.6%, respectively. Generally, the patients accepted the anesthetic procedure well. The residual perception of pain and unpleasantness following topical anesthesia may be dependent on activation of nonanesthetized nociceptive fibers in the tooth pulp. However, the present study clearly demonstrates the efficacy of a topical anesthetic in a clinical situation, which may be recommended as a simple pharmacologic strategy to reduce pain and unpleasantness during scaling procedures.

Topics: Administration, Topical; Adult; Anesthesia, Dental; Anesthesia, Local; Anesthetics, Local; Dental Scaling; Double-Blind Method; Drug Combinations; Facial Pain; Female; Gingival Pocket; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Pain Measurement; Periodontal Dressings; Periodontitis; Prilocaine; Statistics, Nonparametric

Topics: Adolescent; Anesthetics, Combined; Anesthetics, Local; Child; Facial Pain; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Ointments; Orthodontics, Corrective; Prilocaine

In this study, four anesthetic agents of different forms and contents, namely: EMLA 5% Cream (lidocaine 2.5 percent, prilocaine 2.5 percent), Vision-Gel (benzocaine 20 percent), Anesthetic Tabs (tetracaine hydrochloride 0.68 mg, cincocain hydrochloride 0.02 mg), Xylocaine 10% aerosol (lidocaine 10 percent) were evaluated in terms of effectiveness in decreasing the intra-oral injection pain. Six groups each consisting of 20 children were constituted from 120 children aged between 10-15 years. The responses of the patients to the pain were evaluated using a visual analogue scale. Consequently, of all the other anesthetic agents used in the present study, Vision Gel was observed to be the most effective.

Topics: Administration, Topical; Adolescent; Anesthesia, Dental; Anesthetics, Local; Benzocaine; Child; Dibucaine; Evaluation Studies as Topic; Facial Pain; Female; Gels; Humans; Injections; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Pain Measurement; Prilocaine; Tetracaine

Topics: Anesthetics, Local; Facial Pain; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Nervous System Diseases; Pain Measurement; Prilocaine; Toothache