psd-502 and Drug-Overdose

psd-502 has been researched along with Drug-Overdose* in 2 studies

Other Studies

2 other study(ies) available for psd-502 and Drug-Overdose

Article	Year
[Intoxication with prilocaine/lidocaine can cause serious methemoglobinemia]. Lakartidningen, 2019, Oct-01, Volume: 116 Prilocaine/lidocaine is widely used as local anesthetic in children for cannulation and minor surgical procedures. Usually it is unproblematic but it is important to adhere to recommended dose to avoid serious complications. Excessive amount of prilocaine/lidocaine, large application area, prolonged application time or repeated application can, especially in infants, cause methemoglobinemia with clinical symptoms. In severe cases intensive care and antidote treatment with Methylene blue may be required. We report three infants who were overdosed with prilocaine/lidocaine, two of them due to incorrect use after circumcision and one premature baby where prilocaine/lidocaine was not removed in time. Two of the babies had MetHb levels > 33% and were seriously affected with hypoxia, tachycardia and fatigue. After Methylene blue was given the infants recovered within 15 minutes and MetHb levels returned to normal. Topics: Anesthetics, Combined; Anesthetics, Local; Blood Gas Analysis; Drug Overdose; Enzyme Inhibitors; Humans; Infant, Newborn; Lidocaine, Prilocaine Drug Combination; Male; Methemoglobinemia; Methylene Blue	2019
[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose]. Annales de dermatologie et de venereologie, 2012, Volume: 139, Issue:12 Emla(®) cream, a mixture of two local anaesthetics (prilocaine 2.5%, lidocaine 2.5%) has a good benefit-risk profile. However, methaemoglobinaemia can occur, especially when the cream is applied in excessive amounts or over long periods.. The authors report a case of seizure and respiratory disturbances (MetHb=20.1%) after excessive application of Emla(®) (30g) for curettage of molluscum contagiosum in a young girl with eczema. The patient's clinical condition improved after withdrawal of the cream and administration of methylene blue, and she returned home on day two.. This new case of methaemoglobinaemia in a child following application of Emla(®) cream highlights the importance of strict compliance with the instructions for use of this medicinal product. Topics: Anesthetics, Combined; Child, Preschool; Dosage Forms; Drug Overdose; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methemoglobinemia; Prilocaine	2012

Article

Year

[Intoxication with prilocaine/lidocaine can cause serious methemoglobinemia].

Lakartidningen, 2019, Oct-01, Volume: 116

Prilocaine/lidocaine is widely used as local anesthetic in children for cannulation and minor surgical procedures. Usually it is unproblematic but it is important to adhere to recommended dose to avoid serious complications. Excessive amount of prilocaine/lidocaine, large application area, prolonged application time or repeated application can, especially in infants, cause methemoglobinemia with clinical symptoms. In severe cases intensive care and antidote treatment with Methylene blue may be required. We report three infants who were overdosed with prilocaine/lidocaine, two of them due to incorrect use after circumcision and one premature baby where prilocaine/lidocaine was not removed in time. Two of the babies had MetHb levels > 33% and were seriously affected with hypoxia, tachycardia and fatigue. After Methylene blue was given the infants recovered within 15 minutes and MetHb levels returned to normal.

Topics: Anesthetics, Combined; Anesthetics, Local; Blood Gas Analysis; Drug Overdose; Enzyme Inhibitors; Humans; Infant, Newborn; Lidocaine, Prilocaine Drug Combination; Male; Methemoglobinemia; Methylene Blue

2019

[Methaemoglobinaemia in a child treated with Emla(®) cream: circumstances and consequences of overdose].

Annales de dermatologie et de venereologie, 2012, Volume: 139, Issue:12

Emla(®) cream, a mixture of two local anaesthetics (prilocaine 2.5%, lidocaine 2.5%) has a good benefit-risk profile. However, methaemoglobinaemia can occur, especially when the cream is applied in excessive amounts or over long periods.. The authors report a case of seizure and respiratory disturbances (MetHb=20.1%) after excessive application of Emla(®) (30g) for curettage of molluscum contagiosum in a young girl with eczema. The patient's clinical condition improved after withdrawal of the cream and administration of methylene blue, and she returned home on day two.. This new case of methaemoglobinaemia in a child following application of Emla(®) cream highlights the importance of strict compliance with the instructions for use of this medicinal product.

Topics: Anesthetics, Combined; Child, Preschool; Dosage Forms; Drug Overdose; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Methemoglobinemia; Prilocaine

2012