psd-502 and Condylomata-Acuminata

Topics: Absorption; Anesthesia, Local; Child; Condylomata Acuminata; Drug Combinations; Female; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Pain; Prilocaine

Surgical procedures used to remove genital warts (cryotherapy, electrodesiccation) are painful. Attempts to reduce the discomfort of surgery by prior lidocaine infiltration anesthesia are compromised by the pain of the infiltration.. Our purpose was to determine the efficacy of topically applied lidocaine/prilocaine cream to reduce the pain of lidocaine infiltration and the pain associated with cryotherapy to remove genital warts.. Men, scheduled for removal of genital warts by cryotherapy, were randomly selected to receive one of three treatments: (1) lidocaine/prilocaine cream application, (2) 1% lidocaine infiltration, and (3) lidocaine/prilocaine cream application followed by infiltration of 1% lidocaine.. Application of lidocaine/prilocaine cream for 15 minutes markedly reduced the pain of lidocaine infiltration. The combination of lidocaine/prilocaine cream followed by infiltration of 1% lidocaine gave greater pain relief from the cryotherapy than did either anesthetic alone.. The application of lidocaine/prilocaine cream as an adjunct to lidocaine infiltration reduced the pain of infiltration and the pain associated with cryotherapy for the removal of genital warts.

Topics: Anesthesia, Local; Anesthetics, Combined; Anesthetics, Local; Condylomata Acuminata; Cryotherapy; Drug Combinations; Genital Diseases, Male; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Ointments; Pain Measurement; Prilocaine

The efficacy of the anesthesia by the Emla cream (a mixture of lydocaine and prylocaine) has been tested on the cervix uteri and the vulva before laser treatment of warts and intraepithelial neoplasia. Five of the six women treated for vulvar warts did not feel any pain during laser treatment after the application of the cream. On the cervix, the pain was evaluated on a median of 9 on a visual scale going from 0 to 100, compared to a median of 25 for women treated without local anesthesia. The efficacy of local anesthesia was best after 4 minutes. The local anesthesia by the Emla cream seems to constitute a real progress in the patient's tolerance of local destructive treatment of cervical and vulvar warts and intraepithelial neoplasia.

Topics: Anesthetics, Combined; Anesthetics, Local; Condylomata Acuminata; Female; Humans; Laser Therapy; Lidocaine; Lidocaine, Prilocaine Drug Combination; Pain; Pain Measurement; Prilocaine; Time Factors; Uterine Cervical Diseases; Uterine Cervical Dysplasia; Vulvar Diseases

The time of onset and duration of local anesthesia of a lidocaine/prilocaine cream (EMLA) applied to the genital mucosa were assessed in a double-blind study. Eighty women with condylomata on their genital mucosa were randomly allocated to either EMLA (N = 60) or placebo cream (N = 20) between 1-75 minutes before CO2 laser treatment. The pain was evaluated by the patient on a visual analogue scale. The most effective degree of anesthesia was achieved after 5-15 minutes' application of EMLA. The patients given EMLA, regardless of application time, felt significantly less pain than the patients given placebo. EMLA could provide an alternative to general anesthesia in patients with extensive condylomata on the genital mucosa.

Topics: Adolescent; Adult; Anesthetics, Local; Condylomata Acuminata; Double-Blind Method; Drug Combinations; Female; Humans; Laser Therapy; Lidocaine; Lidocaine, Prilocaine Drug Combination; Middle Aged; Prilocaine; Randomized Controlled Trials as Topic; Vaginal Creams, Foams, and Jellies; Vulvar Neoplasms

Treatment of genital warts (HPV lesions) by Laser-surgery was performed in 90 patients and 90 male partners under topical anaesthesia with 1-3 gr EMLA cream and in 45 patients and 45 males (control groups) under 1-2 ml 2% Carbocaine infiltration. EMLA cream was applied to warts 5-18 minutes (median = 7) before operation. Pain from application of anaesthetic and Laser surgery was significantly less (p < .001) in the groups treated by EMLA. Side effects were minimal in the EMLA groups. The results suggest that EMLA cream could be the anaesthetic of choice in Laser surgery of genital warts.

Topics: Adolescent; Adult; Aged; Anesthetics, Local; Condylomata Acuminata; Drug Combinations; Female; Humans; Laser Therapy; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Middle Aged; Papillomaviridae; Prilocaine; Tumor Virus Infections

Using an percutaneous anesthetic Lidocaine ointment (EMLA cream 5%), we treated patients with mollusca contagiosa, condylomata acuminata, and verrucae plantaris by superficial curettage or electrocaustic surgery. The same presurgical procedure was applied in taking biopsies from the glans penis. The analgesia achieved was complete in all patients with mollusca contagiosa, condylomata acuminata, and penal biopsies. In those with verrucae plantaris, the anesthesia was incomplete but tolerable, also in children. We discuss the pharmacological effects of and further indications for this new percutaneous anesthetic ointment.

Topics: Anesthetics, Local; Biopsy; Condylomata Acuminata; Drug Combinations; Electrocoagulation; Humans; Lidocaine; Lidocaine, Prilocaine Drug Combination; Male; Molluscum Contagiosum; Ointments; Penile Neoplasms; Prilocaine; Skin Diseases; Skin Neoplasms; Warts