psb603 and Spinal-Cord-Injuries

Neurogenic detrusor overactivity (NDO) is among the most challenging complications of spinal cord injury (SCI). A recent report by us demonstrated an improvement in NDO in SCI rats following chronic systemic treatment with the purine nucleoside inosine. The objective of this study was to investigate the mechanism of action of inosine underlying improvement of NDO. Male Sprague-Dawley rats underwent complete spinal cord transection at T8. Inosine (1 mM) delivered intravesically to SCI rats during conscious cystometry significantly decreased the frequency of spontaneous non-voiding contractions. In isolated tissue assays, inosine (1 mM) significantly decreased the amplitude of spontaneous activity (SA) in SCI bladder muscle strips. This effect was prevented by a pan-adenosine receptor antagonist CGS15943, but not by A

Topics: Adenosine A2 Receptor Antagonists; Animals; Disease Models, Animal; Humans; Inosine; Potassium Channels; Rats; Receptor, Adenosine A2A; Spinal Cord Injuries; Sulfonamides; Triazines; Triazoles; Urinary Bladder, Neurogenic; Urinary Bladder, Overactive; Xanthines