ps-540446 and Disease-Models--Animal

ps-540446 has been researched along with Disease-Models--Animal* in 1 studies

Other Studies

1 other study(ies) available for ps-540446 and Disease-Models--Animal

Article	Year
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors. Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15 Pyrrolo[2,1-f][1,2,4]triazine based inhibitors of p38α have been prepared exploring functional group modifications at the C6 position. Incorporation of aryl and heteroaryl ketones at this position led to potent inhibitors with efficacy in in vivo models of acute and chronic inflammation. Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis; Binding Sites; Crystallography, X-Ray; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Mice; Mitogen-Activated Protein Kinase 14; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrroles; Rats; Structure-Activity Relationship; Triazines	2011

Article

Year

Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.

Bioorganic & medicinal chemistry letters, 2011, Aug-01, Volume: 21, Issue:15

Pyrrolo[2,1-f][1,2,4]triazine based inhibitors of p38α have been prepared exploring functional group modifications at the C6 position. Incorporation of aryl and heteroaryl ketones at this position led to potent inhibitors with efficacy in in vivo models of acute and chronic inflammation.

Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arthritis; Binding Sites; Crystallography, X-Ray; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Mice; Mitogen-Activated Protein Kinase 14; Protein Kinase Inhibitors; Protein Structure, Tertiary; Pyrroles; Rats; Structure-Activity Relationship; Triazines

2011