Page last updated: 2024-11-03

protoporphyrin ix and Urinary Bladder Neoplasms

protoporphyrin ix has been researched along with Urinary Bladder Neoplasms in 53 studies

protoporphyrin IX: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7685
protoporphyrin : A cyclic tetrapyrrole that consists of porphyrin bearing four methyl substituents at positions 3, 8, 13 and 17, two vinyl substituents at positions 7 and 12 and two 2-carboxyethyl substituents at positions 2 and 18. The parent of the class of protoporphyrins.

Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.

Research Excerpts

ExcerptRelevanceReference
"The mechanism underlying the increased levels of protoporphyrin IX in bladder cancer remains unclear."7.83Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer. ( Anai, S; Chihara, Y; Fujimoto, K; Hirao, Y; Kuwada, M; Miyake, M; Nakai, Y; Onishi, S; Tanaka, N; Tatsumi, Y, 2016)
"We evaluated the feasibility of photodynamic diagnosis of bladder cancer by spectrophotometric analysis of voided urine samples after extracorporeal treatment with 5-aminolevulinic acid (ALA)."7.81Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer. ( Anai, S; Chihara, Y; Fujimoto, K; Hirao, Y; Masaomi, K; Miyake, M; Nakai, Y; Onishi, S; Tanaka, N; Tatsumi, Y, 2015)
"5-aminolevulinic acid mediated changes in tissue specific fluorescence were studied in bladder cancer."7.72Fluorescence confocal microscopy and image analysis of bladder cancer using 5-aminolevulinic acid. ( Christopher, C; Hoon, TP; Lau, W; Manivasager, V; Olivo, M, 2003)
"5-Aminolevulinic acid (ALA) is a precursor of protoporphyrin IX (PpIX) that is being evaluated for use in photodiagnosis and phototherapy of malignant and nonmalignant disorders."6.70Clinical pharmacokinetics of 5-aminolevulinic acid in healthy volunteers and patients at high risk for recurrent bladder cancer. ( Dalton, JT; Golub, AL; Marcus, SL; Meyer, MC; Straughn, A; Yates, CR; Yin, D, 2002)
" The usefulness of intracellularly accumulated endogenous protoporphyrin IX (PPIX), induced by 5-aminolevulinic acid (ALA), for diagnosis of early bladder cancer and the correlation with cystoscopic, microscopic, and fluorescence findings was investigated."5.07Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid. ( Baumgartner, R; Ehsan, A; Hofstädter, F; Hofstetter, A; Knuechel, R; Kriegmair, M; Lumper, W; Steinbach, P, 1994)
"Hexaminolevulinate (HAL) induced Protoporphyrin IX (PpIX) fluorescence is commonly used to differentiate cancer cells from normal cells in vivo, as for instance in blue light cystoscopy for bladder cancer diagnosis."4.02Improving hexaminolevulinate enabled cancer cell detection in liquid biopsy immunosensors. ( Chan, KM; Gleadle, J; Li, J; MacGregor, M; Michl, TD; Vasilev, K, 2021)
"The mechanism underlying the increased levels of protoporphyrin IX in bladder cancer remains unclear."3.83Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer. ( Anai, S; Chihara, Y; Fujimoto, K; Hirao, Y; Kuwada, M; Miyake, M; Nakai, Y; Onishi, S; Tanaka, N; Tatsumi, Y, 2016)
"We evaluated the feasibility of photodynamic diagnosis of bladder cancer by spectrophotometric analysis of voided urine samples after extracorporeal treatment with 5-aminolevulinic acid (ALA)."3.81Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer. ( Anai, S; Chihara, Y; Fujimoto, K; Hirao, Y; Masaomi, K; Miyake, M; Nakai, Y; Onishi, S; Tanaka, N; Tatsumi, Y, 2015)
"This study shows that PVP-hypericin appears to have great potential as a photodynamic agent against non-muscle-invasive bladder cancers after intravesical administration, with a limited risk of affecting the deeper layers of the bladder."3.77Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder. ( de Witte, PA; Hettinger, K; Van Cleynenbreugel, B; Van Poppel, H; Vandepitte, J, 2011)
"5-aminolevulinic acid mediated changes in tissue specific fluorescence were studied in bladder cancer."3.72Fluorescence confocal microscopy and image analysis of bladder cancer using 5-aminolevulinic acid. ( Christopher, C; Hoon, TP; Lau, W; Manivasager, V; Olivo, M, 2003)
"A major problem diagnosing bladder cancer using conventional white-light cystoscopy is that flat and tiny papillary neoplasms can be overlooked."2.70Diagnostic efficacy of fluorescence cystoscopy for detection of urothelial neoplasms. ( Chai, SE; Choi, HY; Hong, JH; Jeon, SS; Kang, I, 2001)
"5-Aminolevulinic acid (ALA) is a precursor of protoporphyrin IX (PpIX) that is being evaluated for use in photodiagnosis and phototherapy of malignant and nonmalignant disorders."2.70Clinical pharmacokinetics of 5-aminolevulinic acid in healthy volunteers and patients at high risk for recurrent bladder cancer. ( Dalton, JT; Golub, AL; Marcus, SL; Meyer, MC; Straughn, A; Yates, CR; Yin, D, 2002)
"A better understanding of why cancer cells fluoresce with 5-ALA would improve its use in cancer diagnostics and therapies."2.61In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid? ( Gleadle, JM; MacGregor, MN; McNicholas, K, 2019)
"Bladder cancer is the most common tumor of the urinary tract, with a worldwide incidence of 8."2.49Innovations in the endoscopic management of bladder cancer: is the era of white light cystoscopy over. ( Ambrosini, E; Frea, B; Giona, S; Gontero, P; Gurioli, A; Oderda, M; Peraldo, F; Soria, F, 2013)
"Recurrent bladder cancer is due to tumor cell implantation, incomplete resection, and multicentric neoplastic changes throughout the bladder."2.41Endoscopic fluorescence diagnosis and laser treatment of transitional cell carcinoma of the bladder. ( Frimberger, D; Hofstetter, A; Zaak, D, 2000)
"The accumulation of PpIX in bladder cancer cells was significantly higher than in non-cancer cells, both cultured monolayer cells and cells in suspension."1.51Biosensor device for the photo-specific detection of immuno-captured bladder cancer cells using hexaminolevulinate: An ex-vivo study. ( Chan, KM; Gleadle, J; Li, J; MacGregor, M; McNicholas, K; Shirazi, HS; Vasilev, K, 2019)
"Non-muscle invasive bladder cancer can be missed during white light endoscopy in up to 50% of cases."1.42Laser-induced autofluorescence spectroscopy: can it be of importance in detection of bladder lesions? ( Aboumarzouk, O; Ahmad, S; Buist, R; Eljamel, S; Kata, SG; Moseley, H; Nabi, G; Valentine, R, 2015)
"5-Aminolevulinic acid (ALA) is a widely used photodynamic therapy (PDT) prodrug in the clinic."1.42Immobilization of ALA-Zn(II) Coordination Polymer Pro-photosensitizers on Magnetite Colloidal Supraparticles for Target Photodynamic Therapy of Bladder Cancer. ( Guo, J; Sun, C; Tan, J; Wang, C; Xu, K, 2015)
" Lipophilicity is one of the key parameters defining the bioavailability of a topically applied drug."1.315-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells. ( Juillerat-Jeanneret, L; Lange, N; Uehlinger, P; van den Bergh, H; Wagnières, G; Zellweger, M, 2000)
" The elimination half-life of 5-ALA amounted to 0."1.31Intravesical administration of 5-aminolevulinic acid (5-ALA). Safety and pharmacokinetics of 5-ALA and its metabolite protoporphyrin IX. ( Birkel, M; Popken, G; Schultze-Seemann, W; Seiler, KU; Wetterauer, U, 2000)
"The prognosis of superficial bladder cancer in terms of recurrence and disease progression is related to bladder tumor multiplicity and the presence of concomitant "plane" tumors such as high-grade dysplasia and carcinoma in situ."1.30Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer. ( Forrer, M; Graber, P; Guillou, L; Jichlinski, P; Leisinger, HJ; Mizeret, J; Oswald, M; Schmidlin, F; Van den Bergh, H; Wagnières, G, 1997)
"The prognosis of superficial bladder cancer in terms of local recurrence and transformation into invasive cancer is related to the multiplicity of tumor sites and the concomitant presence of "flat" tumours, such as dysplasia and carcinoma in situ."1.30[The clinical value of fluorescence cystoscopy in the detection of superficial transitional epithelial cell carcinoma of the bladder]. ( Forrer, M; Graber, P; Guillou, L; Jichlinski, P; Leisinger, HJ; Mizeret, J; Schmidlin, F; Van den Bergh, H; Wagniéres, G, 1997)
"Rats bearing orthotopic bladder tumors were treated either intravesically or intravenously with graded doses of 5-aminolevulinic acid (ALA) or PII."1.30Biodistribution of Photofrin II and 5-aminolevulinic acid-induced protoporphyrin IX in normal rat bladder and bladder tumor models: implications for photodynamic therapy. ( Brown, KM; Lown, JW; McCallum, TJ; Miller, GG; Moore, RB; Tulip, J; Xiao, Z, 1998)
"This study used bladder cancer cells, incubated with ALA at various oxygen tensions and H+ ion concentrations, and assessed the effects on PpIX generation and PDT sensitivity."1.30The influence of hypoxia and pH on aminolaevulinic acid-induced photodynamic therapy in bladder cancer cells in vitro. ( Brown, NJ; Reed, MW; Wyld, L, 1998)
"5-Aminolevulinic acid (ALA) is a precursor of heme biosynthesis."1.29Biodistribution and phototoxicity of 5-aminolevulinic acid-induced PpIX in an orthotopic rat bladder tumor model. ( Bachor, R; Flotte, T; Hasan, T; Iinuma, S, 1995)
"Following transurethral resection of bladder cancer, the fate of patients is clearly related to the presence or absence of precancerous or malignant lesions in the remaining mucosa."1.29[Photodynamic diagnosis of urothelial neoplasms after intravesicular instillation of 5-aminolevulinic acid]. ( Baumgartner, R; Ehsan, A; Hofstädter, F; Hofstetter, A; Knüchel, R; Kriegmair, M; Lumper, W; Steinbach, P, 1994)
"5-Aminolevulinic acid was instilled prior to cystoscopy and biopsies were taken of lesions that were either fluorescing or nonfluorescing."1.29Intravesical instillation of 5-aminolevulinic acid: the fluorescent metabolite is limited to urothelial cells. ( Baumgartner, R; Hofstädter, F; Knüchel, R; Kriegmair, M; Steinbach, P, 1994)
"Aminolevulinic acid (ALA) is a precursor of protoporphyrin IX (PP IX), a potent photosensitizer."1.29Aminolevulinic acid for photodynamic therapy of bladder carcinoma cells. ( Bachor, R; Hautmann, R; Reich, E; Rück, A, 1996)

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's21 (39.62)18.2507
2000's20 (37.74)29.6817
2010's11 (20.75)24.3611
2020's1 (1.89)2.80

Authors

AuthorsStudies
Chan, KM2
Vasilev, K2
Shirazi, HS1
McNicholas, K2
Li, J2
Gleadle, J2
MacGregor, M2
MacGregor, MN1
Gleadle, JM1
Michl, TD1
Inoue, K4
Fukuhara, H2
Kurabayashi, A3
Furihata, M3
Tsuda, M1
Nagakawa, K1
Fujita, H2
Utsumi, K2
Shuin, T3
Soria, F1
Gurioli, A1
Peraldo, F1
Oderda, M1
Giona, S1
Ambrosini, E1
Frea, B1
Gontero, P1
Hagiya, Y1
Matsumoto, K1
Endo, Y1
Nakajima, M1
Tanaka, T1
Okura, I1
Ogura, S1
Aboumarzouk, O1
Valentine, R1
Buist, R1
Ahmad, S1
Nabi, G1
Eljamel, S1
Moseley, H1
Kata, SG1
Nakai, Y2
Anai, S2
Onishi, S2
Masaomi, K1
Tatsumi, Y2
Miyake, M2
Chihara, Y2
Tanaka, N2
Hirao, Y2
Fujimoto, K2
Kuwada, M1
Tan, J1
Sun, C1
Xu, K1
Wang, C1
Guo, J1
Berrahmoune, S1
Fotinos, N1
Bezdetnaya, L2
Lange, N5
Guedenet, JC1
Guillemin, F2
D'Hallewin, MA1
Karashima, T1
Kamada, M1
Sasaki, J1
Vandepitte, J1
Van Cleynenbreugel, B1
Hettinger, K1
Van Poppel, H1
de Witte, PA1
Manivasager, V2
Heng, PW1
Hao, J1
Zheng, W1
Soo, KC1
Olivo, M2
Lau, W1
Hoon, TP1
Christopher, C1
Marti, A2
Jichlinski, P7
Ballini, JP1
Guillou, L5
Leisinger, HJ5
Kucera, P3
Hjelde, A1
Gederaas, OA1
Krokan, HE1
Brubakk, AO1
Tauber, S1
Stepp, H3
Meier, R1
Bone, A1
Hofstetter, A7
Stief, C1
Vaucher, L1
Ritter-Schenk, C1
van den Bergh, H7
Cunderlíková, B1
Wahlqvist, R1
Berner, A1
Vasovic, V1
Warloe, T1
Nesland, JM1
Peng, Q1
Forster, TH1
Wyler, S1
Ruszat, R1
Gasser, TC1
Bachmann, A1
Mizeret, J4
Forrer, M5
Wagnière, G1
Schmidlin, F4
Graber, P4
Iinuma, S2
Bachor, R2
Flotte, T1
Hasan, T2
Kriegmair, M6
Baumgartner, R9
Knüchel, R5
Ehsan, A3
Steinbach, P5
Lumper, W3
Hofstädter, F4
Knuechel, R4
Farshi, SS1
Ortel, B1
König, K1
Schneckenburger, H1
Rück, A2
Steiner, R1
Weingandt, H1
Stepp, HG1
Rick, K1
Reich, E1
Hautmann, R1
Wagnières, G5
Oswald, M1
Glanzmann, T1
Braichotte, D1
Zimmer, G1
Heil, P1
Stocker, S1
Sroka, R1
Koenig, F1
McGovern, FJ1
Xiao, Z1
Miller, GG1
McCallum, TJ1
Brown, KM1
Lown, JW1
Tulip, J1
Moore, RB2
Wyld, L2
Reed, MW2
Brown, NJ2
Smith, O1
Lawry, J1
Li, G1
Szewczuk, MR1
Raptis, L1
Johnson, JG1
Weagle, GE1
Pottier, RH1
Kennedy, JC1
Zellweger, M2
Zaak, D3
Uehlinger, P1
Juillerat-Jeanneret, L1
Krieg, RC2
Fickweiler, S1
Wolfbeis, OS1
Popken, G1
Schultze-Seemann, W1
Seiler, KU1
Birkel, M1
Wetterauer, U1
Frimberger, D2
Cosserat-Gerardin, I1
Notter, D1
Vigneron, C1
Seidl, J1
Rauch, J1
Appel, S1
Schneede, P1
Schmeller, N1
Jeon, SS1
Kang, I1
Hong, JH1
Choi, HY1
Chai, SE1
Gronlund-Pakkanen, S1
Wahlfors, J1
Makinen, K1
Pakkanen, TM1
Talja, M1
Ala-Opas, M1
Alhava, E1
Dalton, JT1
Yates, CR1
Yin, D1
Straughn, A1
Marcus, SL1
Golub, AL1
Meyer, MC1

Reviews

5 reviews available for protoporphyrin ix and Urinary Bladder Neoplasms

ArticleYear
In order for the light to shine so brightly, the darkness must be present-why do cancers fluoresce with 5-aminolaevulinic acid?
    British journal of cancer, 2019, Volume: 121, Issue:8

    Topics: Amino Acid Transport Systems; Aminolevulinic Acid; Brain Neoplasms; Coproporphyrinogens; Ferrochelat

2019
Innovations in the endoscopic management of bladder cancer: is the era of white light cystoscopy over.
    Urologia, 2013, Volume: 80 Spec No 1

    Topics: Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Transitional Cell; Cystoscopy; False Negative Rea

2013
5-Aminolevulinic acid-mediated photodynamic therapy for bladder cancer.
    International journal of urology : official journal of the Japanese Urological Association, 2017, Volume: 24, Issue:2

    Topics: Aminolevulinic Acid; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins; Treatment

2017
["... The better to see you with"--phothodynamic diagnostic in superficial bladder cancer].
    Praxis, 2007, Oct-17, Volume: 96, Issue:42

    Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Carcinoma in Situ; Carcinoma, Papillary;

2007
Endoscopic fluorescence diagnosis and laser treatment of transitional cell carcinoma of the bladder.
    Seminars in urologic oncology, 2000, Volume: 18, Issue:4

    Topics: Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopy; Fluorescence; Humans; Laser Therapy;

2000

Trials

6 trials available for protoporphyrin ix and Urinary Bladder Neoplasms

ArticleYear
Comparison of aminolevulinic acid and hexylester aminolevulinate induced protoporphyrin IX distribution in human bladder cancer.
    The Journal of urology, 2003, Volume: 170, Issue:2 Pt 1

    Topics: Administration, Intravesical; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional

2003
Fluorescence photodetection of neoplastic urothelial lesions following intravesical instillation of 5-aminolevulinic acid.
    Urology, 1994, Volume: 44, Issue:6

    Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cystoscopy; Femal

1994
Photodetection of early human bladder cancer based on the fluorescence of 5-aminolaevulinic acid hexylester-induced protoporphyrin IX: a pilot study.
    British journal of cancer, 1999, Volume: 80, Issue:1-2

    Topics: Aged; Aminolevulinic Acid; Female; Fluorescence; Humans; Male; Middle Aged; Photochemotherapy; Photo

1999
Photodynamic cystoscopy for detection of bladder tumors.
    Seminars in laparoscopic surgery, 1999, Volume: 6, Issue:2

    Topics: Adenocarcinoma, Papillary; Administration, Intravesical; Aminolevulinic Acid; Biopsy; Cystoscopy; Di

1999
Diagnostic efficacy of fluorescence cystoscopy for detection of urothelial neoplasms.
    Journal of endourology, 2001, Volume: 15, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma in Situ; Cystoscopy; Female; Fluoresc

2001
Clinical pharmacokinetics of 5-aminolevulinic acid in healthy volunteers and patients at high risk for recurrent bladder cancer.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:2

    Topics: Administration, Intravesical; Administration, Oral; Aminolevulinic Acid; Cross-Over Studies; Drug Ad

2002

Other Studies

42 other studies available for protoporphyrin ix and Urinary Bladder Neoplasms

ArticleYear
Biosensor device for the photo-specific detection of immuno-captured bladder cancer cells using hexaminolevulinate: An ex-vivo study.
    Photodiagnosis and photodynamic therapy, 2019, Volume: 28

    Topics: Aminolevulinic Acid; Biosensing Techniques; Cell Line, Tumor; Cystoscopy; Humans; In Vitro Technique

2019
Improving hexaminolevulinate enabled cancer cell detection in liquid biopsy immunosensors.
    Scientific reports, 2021, 03-31, Volume: 11, Issue:1

    Topics: Aminolevulinic Acid; Biosensing Techniques; Cell Line, Tumor; Cells, Cultured; Humans; Immunologic T

2021
Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma.
    Cancer science, 2013, Volume: 104, Issue:6

    Topics: Aminolevulinic Acid; Angiogenesis Inhibitors; Animals; Apoptosis; Carcinoma, Transitional Cell; Cell

2013
Expression levels of PEPT1 and ABCG2 play key roles in 5-aminolevulinic acid (ALA)-induced tumor-specific protoporphyrin IX (PpIX) accumulation in bladder cancer.
    Photodiagnosis and photodynamic therapy, 2013, Volume: 10, Issue:3

    Topics: Aminolevulinic Acid; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette T

2013
Laser-induced autofluorescence spectroscopy: can it be of importance in detection of bladder lesions?
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:1

    Topics: Aged; Aged, 80 and over; Humans; Image Interpretation, Computer-Assisted; Lasers; Middle Aged; Optic

2015
Protoporphyrin IX induced by 5-aminolevulinic acid in bladder cancer cells in voided urine can be extracorporeally quantified using a spectrophotometer.
    Photodiagnosis and photodynamic therapy, 2015, Volume: 12, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cell Line, Tumor; Female; Humans; Male; Middle

2015
Expression of ferrochelatase has a strong correlation in protoporphyrin IX accumulation with photodynamic detection of bladder cancer.
    Photodiagnosis and photodynamic therapy, 2016, Volume: 13

    Topics: Aminolevulinic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cells, Cultured; Cystoscopy; Ferrochelatas

2016
Immobilization of ALA-Zn(II) Coordination Polymer Pro-photosensitizers on Magnetite Colloidal Supraparticles for Target Photodynamic Therapy of Bladder Cancer.
    Small (Weinheim an der Bergstrasse, Germany), 2015, Dec-16, Volume: 11, Issue:47

    Topics: Aminolevulinic Acid; Blotting, Western; Cell Death; Cell Line, Tumor; Colloids; Ferrosoferric Oxide;

2015
Analysis of differential PDT effect in rat bladder tumor models according to concentrations of intravesical hexyl-aminolevulinate.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2008, Volume: 7, Issue:9

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Disease Models

2008
Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX accumulation in human urothelial carcinomas.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 2009, Volume: 76, Issue:6

    Topics: Aminolevulinic Acid; beta-Alanine; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carcinoma, Tr

2009
Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:4

    Topics: Aminolevulinic Acid; Animals; Anthracenes; Antineoplastic Agents; Female; Fluorescence; Perylene; Ph

2011
A study of 5-aminolevulinic acid and its methyl ester used in in vitro and in vivo systems of human bladder cancer.
    International journal of oncology, 2003, Volume: 22, Issue:2

    Topics: Administration, Topical; Aminolevulinic Acid; Animals; Biological Transport, Active; Carcinoma; Cyst

2003
Fluorescence confocal microscopy and image analysis of bladder cancer using 5-aminolevulinic acid.
    International journal of oncology, 2003, Volume: 22, Issue:3

    Topics: Administration, Intravesical; Aminolevulinic Acid; Biomarkers, Tumor; Carcinoma in Situ; Carcinoma,

2003
Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines.
    Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:10

    Topics: Aminolevulinic Acid; Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Hyperoxia; Lipid Peroxida

2005
Integral spectrophotometric analysis of 5-aminolaevulinic acid-induced fluorescence cytology of the urinary bladder.
    BJU international, 2006, Volume: 97, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Female; Humans; M

2006
Hexyl-aminolevulinate-mediated photodynamic therapy: how to spare normal urothelium. An in vitro approach.
    Lasers in surgery and medicine, 2007, Volume: 39, Issue:1

    Topics: Aminolevulinic Acid; Animals; Cell Survival; In Vitro Techniques; Microscopy, Electron, Scanning; Mu

2007
Detection of urinary bladder cancer with flow cytometry and hexaminolevulinate in urine samples.
    Cytopathology : official journal of the British Society for Clinical Cytology, 2007, Volume: 18, Issue:2

    Topics: Aged; Aged, 80 and over; Aminolevulinic Acid; Biomarkers, Tumor; Carcinoma, Transitional Cell; Cell

2007
[Superficial bladder tumors. Pathological and clinical review and presentation of a new diagnostic method: fluorescence photodetection of transitional epithelial carcinomas based on protoporphyrin IX induction with delta-aminolevulinic acid (5-ALA)].
    Revue medicale de la Suisse romande, 1995, Volume: 115, Issue:3

    Topics: Aged; Aged, 80 and over; Algorithms; Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopy;

1995
Biodistribution and phototoxicity of 5-aminolevulinic acid-induced PpIX in an orthotopic rat bladder tumor model.
    The Journal of urology, 1995, Volume: 153, Issue:3 Pt 1

    Topics: Aminolevulinic Acid; Animals; Female; Neoplasm Transplantation; Photochemotherapy; Protoporphyrins;

1995
[Photodynamic diagnosis of urothelial neoplasms after intravesicular instillation of 5-aminolevulinic acid].
    Der Urologe. Ausg. A, 1994, Volume: 33, Issue:4

    Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Biopsy; Carcinoma

1994
Intravesical instillation of 5-aminolevulinic acid: the fluorescent metabolite is limited to urothelial cells.
    Urology, 1994, Volume: 44, Issue:5

    Topics: Administration, Intravesical; Aminolevulinic Acid; Carcinoma in Situ; Carcinoma, Papillary; Cell Lin

1994
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
    British journal of cancer, 1994, Volume: 70, Issue:1

    Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division;

1994
In vivo photoproduct formation during PDT with ALA-induced endogenous porphyrins.
    Journal of photochemistry and photobiology. B, Biology, 1993, Volume: 18, Issue:2-3

    Topics: Aminolevulinic Acid; Animals; Female; Humans; Kinetics; Light; Mice; Mice, Nude; Neoplasm Transplant

1993
Cellular fluorescence of the endogenous photosensitizer protoporphyrin IX following exposure to 5-aminolevulinic acid.
    Photochemistry and photobiology, 1995, Volume: 62, Issue:5

    Topics: Aminolevulinic Acid; Cell Line; Flow Cytometry; Fluorescence; Humans; Photochemotherapy; Photosensit

1995
Fluorescence cystoscopy following intravesical instillation of 5-aminolevulinic acid: a new procedure with high sensitivity for detection of hardly visible urothelial neoplasias.
    Urologia internationalis, 1995, Volume: 55, Issue:4

    Topics: Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Cystoscopy; Epith

1995
Aminolevulinic acid for photodynamic therapy of bladder carcinoma cells.
    Urological research, 1996, Volume: 24, Issue:5

    Topics: Aminolevulinic Acid; Cell Survival; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyr

1996
Clinical assessment of fluorescence cytoscopy during transurethral bladder resection in superficial bladder cancer.
    Urological research, 1997, Volume: 25 Suppl 1

    Topics: Adult; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma, Transitional Cell; Cystoscopes; Cyst

1997
Clinical evaluation of a method for detecting superficial surgical transitional cell carcinoma of the bladder by light-induced fluorescence of protoporphyrin IX following the topical application of 5-aminolevulinic acid: preliminary results.
    Lasers in surgery and medicine, 1997, Volume: 20, Issue:4

    Topics: Administration, Cutaneous; Administration, Intravesical; Adult; Aged; Aged, 80 and over; Aminolevuli

1997
[The clinical value of fluorescence cystoscopy in the detection of superficial transitional epithelial cell carcinoma of the bladder].
    Annales d'urologie, 1997, Volume: 31, Issue:1

    Topics: Administration, Intravesical; Aged; Aged, 80 and over; Aminolevulinic Acid; Carcinoma in Situ; Carci

1997
In vivo fluorescence kinetics of porphyrins following intravesical instillation of 5-aminolaevulinic acid in normal and tumour-bearing rat bladders.
    Journal of photochemistry and photobiology. B, Biology, 1997, Volume: 38, Issue:2-3

    Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Female; Kinetics; Photosensitizing Agent

1997
Fluorescence detection of bladder carcinoma.
    Urology, 1997, Volume: 50, Issue:5

    Topics: Aged; Fluorescence; Humans; Light; Male; Photosensitizing Agents; Protoporphyrins; Urinary Bladder N

1997
Biodistribution of Photofrin II and 5-aminolevulinic acid-induced protoporphyrin IX in normal rat bladder and bladder tumor models: implications for photodynamic therapy.
    Photochemistry and photobiology, 1998, Volume: 67, Issue:5

    Topics: Aminolevulinic Acid; Animals; Dihematoporphyrin Ether; Disease Models, Animal; Female; Photochemothe

1998
The influence of hypoxia and pH on aminolaevulinic acid-induced photodynamic therapy in bladder cancer cells in vitro.
    British journal of cancer, 1998, Volume: 77, Issue:10

    Topics: Acidosis; Aminolevulinic Acid; Cell Hypoxia; Cell Survival; Humans; Hydrogen-Ion Concentration; Phot

1998
Cell cycle phase influences tumour cell sensitivity to aminolaevulinic acid-induced photodynamic therapy in vitro.
    British journal of cancer, 1998, Volume: 78, Issue:1

    Topics: Aminolevulinic Acid; Cell Cycle; Humans; Photochemotherapy; Photosensitizing Agents; Protoporphyrins

1998
Rodent fibroblast model for studies of response of malignant cells to exogenous 5-aminolevulinic acid.
    British journal of cancer, 1999, Volume: 80, Issue:5-6

    Topics: 3T3 Cells; Aminolevulinic Acid; Animals; Cell Line, Transformed; Cell Transformation, Neoplastic; Ce

1999
5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells.
    Journal of photochemistry and photobiology. B, Biology, 2000, Volume: 54, Issue:1

    Topics: Aminolevulinic Acid; Bronchi; Cell Line; Humans; Hydrogen-Ion Concentration; Kinetics; Lung Neoplasm

2000
Cell-type specific protoporphyrin IX metabolism in human bladder cancer in vitro.
    Photochemistry and photobiology, 2000, Volume: 72, Issue:2

    Topics: Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Cell Division; Ferrochelatase; Humans; Hydrox

2000
Intravesical administration of 5-aminolevulinic acid (5-ALA). Safety and pharmacokinetics of 5-ALA and its metabolite protoporphyrin IX.
    European journal of clinical pharmacology, 2000, Volume: 56, Issue:3

    Topics: Administration, Intravesical; Adult; Aged; Aminolevulinic Acid; Female; Humans; Male; Middle Aged; P

2000
Biosynthesis and photodynamic efficacy of protoporphyrin IX (PpIX) generated by 5-aminolevulinic acid (ALA) or its hexylester (hALA) in rat bladder carcinoma cells.
    Journal of photochemistry and photobiology. B, Biology, 2000, Volume: 59, Issue:1-3

    Topics: Aminolevulinic Acid; Animals; Cell Extracts; Cell Survival; Culture Media; Culture Media, Serum-Free

2000
Optimization of differential photodynamic effectiveness between normal and tumor urothelial cells using 5-aminolevulinic acid-induced protoporphyrin IX as sensitizer.
    International journal of cancer, 2001, Jun-01, Volume: 92, Issue:5

    Topics: Aminolevulinic Acid; Flow Cytometry; Humans; Mitochondria; Photochemotherapy; Photosensitizing Agent

2001
Autofluorescence imaging to optimize 5-ALA-induced fluorescence endoscopy of bladder carcinoma.
    Urology, 2001, Volume: 58, Issue:3

    Topics: Administration, Intravesical; Aminolevulinic Acid; Biopsy; Cystoscopy; Equipment Design; False Posit

2001
The fluorescence biodistribution and kinetics of aminolevulinic acid induced protoporphyrin IX in the bladder of a rat model with orthotopic urothelial carcinoma.
    The Journal of urology, 2002, Volume: 167, Issue:4

    Topics: Administration, Intravesical; Aminolevulinic Acid; Animals; Carcinoma, Transitional Cell; Female; Fl

2002